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qclibre22on Gene linked to long Covid found in analysis of thousands of patients

A lung-specific cis-expression quantitative trait loci (cis-eQTLs) from GTEx v.820 (n = 515) and the Lung eQTL Consortium21 (n = 1,103) provided further support for a subset of loci (Supplementary Table 7), including FOXP4 (chr. 6p21.1) and ABO (chr. 9q34.2), OAS1/OAS3/OAS2 (chr. 12q24.13) and IFNAR2/IL10RB (21q22.11), where the COVID-19-associated variants modify gene expression in lung.

from : https://www.nature.com/articles/s41586-021-03767-x

qclibre22on Gene linked to long Covid found in analysis of thousands of patients

More info: the SNP is rs9367106 ( https://www.ncbi.nlm.nih.gov/snp/rs9367106 )

Preprint is at https://www.medrxiv.org/content/10.1101/2023.06.29.23292056v... .

A link to the UCSC genome browser of the location of the SNP : https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&position=ch...

The location in question is upstream of FOXP4 and in an intron of two genes: FOXP4-AS1 and LINC01276

qclibre22on NIH restarts bat virus grant

High levels of concern in the Chinese government in Fall of 2019 about goings on at WIV are certainly interesting, though circumstantial evidence. On the flip side, there's is little evidence that it wasn't a man-made disaster.

qclibre22on Researchers Overcome Long-Standing Limitation of First Law of Thermodynamics

April 2 minus 1.

qclibre22on Block: Inflated user metrics and “frictionless” fraud facilitation

Banks siding with Silicon Valley firms and not the bank customer is common. Try blocking a vendor that tricked you into signing up. Bank won't help.

qclibre22on A world to win: WebAssembly for the rest of us

How big is it?

qclibre22on Girl who died of bird flu did not have widely-circulating variant (H5N1)

Human challenge vaccine trials.

qclibre22on Getting work done with PowerShell on Linux

Is it installable using vanilla-esque yum or apt?

qclibre22on 1 in 6 retirees are considering returning to work, and 53% want remote positions

3.227% total return, inflation adjusted from Feb 2020 to Feb 2023. Not too bad, actually. See https://dqydj.com/sp-500-return-calculator/ . Perhaps people got used to the 11.883% inflation adjusted total return from Feb 2010 to Feb 2020. Feb 1871 to Feb 2023 is 6.878% .

qclibre22on 1 in 6 retirees are considering returning to work, and 53% want remote positions

What country are connecting from?

qclibre22on Amazon has approval from FTC to acquire One Medical primary-care clinics

>my medical data is with HIPAA.

Except your searching for medical conditions on google or amazon is not protected. They know.

qclibre22on Forget Milk and Eggs: Supermarkets Are Having a Fire Sale on Data About You

Let us know if you figure it out.

qclibre22on Shoichiro Toyoda, who turned Toyota into global automaker, has died

https://www.consumerreports.org/car-reliability-owner-satisf... : "Toyota, Lexus, and BMW are the top three most reliable brands in our annual auto reliability brand rankings"

https://www.forbes.com/wheels/news/consumer-reports-reliabil... : 5 of top 10 are Toyota

qclibre22on WHO abandons plans for second phase of COVID-origins investigation

Jamie Raskin and Alexandria Ocasio-Cortez are in the committee, too, so, yeah, we got the A team on this one.

qclibre22on WHO abandons plans for second phase of COVID-origins investigation

Meanwhile, the U.S. House of Representatives is kicking off an investigation of covid origins: https://www.yahoo.com/news/gop-launches-probe-covid-origins-...

qclibre22on Inflation rose more than expected, up 6.4% from a year ago

No they didn't. They were all green, dropped to flat at 8:30am.

qclibre22on Women’s underwear is taxed at higher rates than Men’s

Found this : https://hts.usitc.gov/view/Chapter%2061?release=2023HTSABasi... Harmonized Tariff Schedule of the United States (2023) ARTICLES OF APPAREL AND CLOTHING ACCESSORIES, KNITTED OR CROCHETED. First mention of "women's" and "men's" : Men's or boys' wool overcoats : 61.7¢/kg + 16% Women's wool coats: 55.9¢/kg +16.4%

Looks like they do have differing tariffs for various items. ( edit: see ksherlock reply at same level for cotton underpants info).

qclibre22on The effect of high-polyphenol Mediterranean diet on visceral adiposity

Good point. Good science should independent of funding and politics. Methodology is not that bad for a nutrition study. I am concerned with compliance verification. A "keep doing whatever" group would have been a great control.

qclibre22on Why does the SARS-Cov2 genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa? (2020)

The stop codon is more like the '\n' or '\0' in computing. Polya tails protect against degradation and is used for nuclear export of RNA.

qclibre22on The effect of high-polyphenol Mediterranean diet on visceral adiposity

I did notice the "the California Walnuts Commission" funded the study.

qclibre22on I changed my mind about nuclear waste

> anthropogenic global warming scientific consensus

Isn't there some serious, vigorous debate on this topic?

qclibre22on Insulin is way too expensive. California has a solution: Make its own

And it's often treatable through diet and vigorous exercise.

"A weight loss of ~15 kg, achieved by calorie restriction as part of an intensive management programme, can lead to remission of T2DM in ~80% of patients with obesity and T2DM." [ https://pubmed.ncbi.nlm.nih.gov/32690918/ ]

"A novel HIIT-protocol recruiting lower and upper body muscles efficiently improves insulin sensitivity, VO2max and body composition with intact responses in obesity and type 2 diabetes. " [ https://pubmed.ncbi.nlm.nih.gov/36387850/ ]

The caveat, is of course, "long-term weight loss maintenance is challenging."

qclibre22on Insulin is way too expensive. California has a solution: Make its own

Liability costs.

qclibre22on Long Covid is keeping significant numbers of people out of work, study finds

Everybody wants a government handout. Nobody wants to pay the taxes to fund it.

qclibre22on Coinbase’s chief product officer will leave with a $105M payday

bitcoin is up 25% in a month : https://finance.yahoo.com/quote/BTC-USD?p=BTC-USD

qclibre22on [dead]

Most "labor shortages" can be fixed by raising wages.

qclibre22on Hyundai Head Unit Hacking

It's a good idea for debugging, a bad idea for security.

qclibre22on Eggs are 60% more expensive than last year in the US

Federal Receipts as Percent of Gross Domestic Product : https://fred.stlouisfed.org/series/FYFRGDA188S

qclibre22on Intel Launches $699 Core I9-13900KS, the First 6 GHz CPU: Available Now

Passmark says they're #1 in single thread : https://www.cpubenchmark.net/singleThread.html

qclibre22on Eggs are 60% more expensive than last year in the US

U.S. has had periods of deflation: https://www.usinflationcalculator.com/inflation/historical-i... . As recently as 2009.