The effect of high-polyphenol Mediterranean diet on visceral adiposity | Hacker News Reader

The effect of high-polyphenol Mediterranean diet on visceral adiposity

bmcmedicine.biomedcentral.com

33 pointslxm9 comments

Very much to do with the Polyphenols inhibiting or increasing Nitric Oxide Synthase.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524723/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723458/

https://academic.oup.com/eurheartj/article/24/13/1210/397048

Myself, I cannot drink green tea or eat chocolate because it inhibits NOS1 and I have a genetic sensitivity (NOS1AP) that causes them to trigger mania, anxiety, and insomnia as do many of the phenols in many plant foods.

https://onlinelibrary.wiley.com/doi/10.1111/gbb.12193

>> Myself, I cannot drink green tea or eat chocolate because it inhibits NOS1 and I have a genetic sensitivity (NOS1AP) that causes them to trigger mania, anxiety, and insomnia as do many of the phenols in many plant foods.

Whoa. Never heard of that, that is quite interesting. I wonder if some people have that sensitivity and not know it.

Interesting. I know that caffeine can induce psychosis and there is also caffeine in both tea and cacao.

Got to be careful in consuming some of these foods and supplements (pre workouts etc, fat-burners) in large quantities.

https://www.cambridge.org/core/journals/cns-spectrums/articl...

How did you encounter that you have that genetic sensitivity?

Obtained my genetics from 23andme, downloaded the raw data and went to work. Learned nutritional genetics in my spare time.

I did notice the "the California Walnuts Commission" funded the study.

Well, it's also sponsored by various government bodies, not that it matters.

If there's a problem with the methodology, why not focus on that?

Private sponsorship being an automatic conflict of interest that compromises research is a tired trope. All you can do is evaluate the methodology. For all you know, the researchers themselves are motivated reasoners with zero funding.

Good point. Good science should independent of funding and politics. Methodology is not that bad for a nutrition study. I am concerned with compliance verification. A "keep doing whatever" group would have been a great control.

So the study participants all lost weight but the study claims even controlling for weight loss the green Med diet eaters lost double the visceral adipose tissue. This is an incredible result given that its the first suggestion I’ve ever seen that you could almost redistribute fat in a healthy way without a negative energy balance. This is like all those BS diet adds online saying “lose wheat belly for those over forty” except true?

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