mjewkes

Where have we seen this? Genuine question.

>3. The renewables industry likes to downplay the sheer volume of fossil fuels required to manufacture the parts. The energy ROI on this is quite poor, and in many cases, we would have been better off skipping the intermediate step and burning the oil and gas directly.

I'm assuming you're referring to Ferroni and Hopkirk (2016) which claimed ERORI of ~0.8-1.7.

You should be aware that their work has been pretty thoroughly picked apart - the rebuttal produced immediately after the above, by 27 international scholars, suggests a ERORI of 7-8. It has likely improved since that time.

https://www.sciencedirect.com/science/article/pii/S030142151...

The top comment on the article itself suggests that the UK’s betting markets don’t have the problems that limit PI.

They are currently +-0.05$ of PI. A material but not enormous difference

Motion Twin is the classic example in the games space http://motion-twin.com/en/

They shipped Dead Cells, which is rated as "Overwhelmingly Positive" "96% of 50,435 reviews" on steam.

https://store.steampowered.com/app/588650/Dead_Cells/

The HaXe programming language originally came out of Motion Twin, although Nicolas Cannasse has since left to do his own thing.

Strilanc, who works on the google quantum team, has a simulator here: https://algassert.com/quirk

0.046%

You didn’t multiply by 100 to change from per unit to per cent.

Still bad though.

Conversely, I'd love to read a Vox editorial that looks for opportunites for government deregulation/step-back.

In their public-facing work, Cowen and pc talk primarily about the importance and upside of progress and growth [1][2]. As someone who leans left, I find these writings both novel and compelling - some of the most compelling market-oriented thinking I've come across.

At the same time, pc, Cowen, and Zuck are in the thick of the SF "conservative libertarian" milieu. Thiel was a/the first major investor in FB, Stripe, and Cowen's "Emergent Ventures". Cowen's Mercatus center has deep ties (that I don't fully understand) with Koch industries and the federalist society. Etc.

I'm _far_ less impressed with the policies actually advocated for by these groups.

I'd actually be really interested in hearing the three of them discuss opportunities for government policy to have significant positive impact. I'd be surprised if pc wasn't a fan of at least some aspects of the FAA / NTSB [3], and I know Cowen advocates for public increases in basic research / R&D investment [4].

As "libertarian conservative" "public thought leaders", I wonder where else they might agree that government intervention can be net very-positive.

[Edit: sorry about the labels. There are real clusters of thinking and people here that need names, but I'm sure that they'd prefer different labels]

[1] https://www.theatlantic.com/science/archive/2019/07/we-need-...

[2] https://www.amazon.com/Stubborn-Attachments-Prosperous-Respo... + thorough review/interview https://80000hours.org/podcast/episodes/tyler-cowen-stubborn...

[3] https://twitter.com/patrickc/status/1021995602970923010

[4] https://marginalrevolution.com/marginalrevolution/2013/02/th...

What's the best way to get in touch? I'm at username [-] google's email.

It's much older than that.

The first bulletproof vest dates to the 1890s, and the inventor photographed tests on himself for publicity.

https://culture.pl/en/article/the-monk-who-stopped-bullets-w...

A doubly linked list is not a good candidate to be written in _safe_ rust.

Lots of other problems are.

>why these highly experimental approaches (e.g reprogramming immune cells) can't be done in animals with cancer

They absolutely are, all the time. Animal testing is relatively cheap (esp. for mice) and widespread in biotech. It's generally hard to get an IND approval (step 1 of human testing) without successful animal tests.

Animal models, unfortunately, aren't super effective at predicting human outcomes.

Yes - if you prove that it is safer than other options for the indicated population, the FDA will approve it with a label indicating it only for that population.

Indications can be as specific as "indicated for tumors with specific mutations"[1] or indicated "prostate cancer when all other options have failed"[2]

[1]https://en.wikipedia.org/wiki/Pembrolizumab [2]https://www.fda.gov/drugs/informationondrugs/approveddrugs/u...

Yep.

Trade Union Congress (TUC) puts real wage growth in germany at 0.9%, and real wage growth in the USA at 1.2%

Source: https://www.tuc.org.uk/news/national/uk-be-bottom-wage-growt...

>If our greatest environmental efforts can at best end in failure

To date, this may be true.

But human cultivaiton _can_ result in an increase in biodiversity and ecological productivity vs non-intervention.

This generally looks like gardening instead of monoculture agriculture.

It may be the case that the biodiversity and ecological productivity of the amazon rainforest was greatly aided by human cultivation. See:

http://science.sciencemag.org/content/355/6328/925

https://en.wikipedia.org/wiki/Terra_preta

https://www.theatlantic.com/science/archive/2017/03/its-now-...

Veeva is a notable counter example. They raised their A round (their only round) once they had a pilot deal in place with Genentech.

Though, at that point at least, Veeva was basically a salesforce reseller.

1TB egress @ DO = $5 = 0.005$/GB...

MotionHall | Software Engineer & Data Munger | SF, Vancouver | ONSITE | Open to Interns (Vancouver only)

MotionHall identifies the best possible development, financing, regulatory, and sales partnerships for emerging biotech companies, helping get their life-saving treatments to market faster and more reliably.

We're super early & pre-seed, but we already have publicly traded customers who want to replace their entire workflow with our software, and leading iBankers who've validated that we're able to deliver better than existing best-in-class results.

We're a small team of 6 (gender balanced and inclusive), so this is a near ground-floor opportunity. Joining us now means learning a lot, grinding a lot (though we're against routine overtime), and being a part of something pretty awesome from early days.

Likely tasks include:

  * Working to develop the skills and processes of our existing engineering team
  * Munging data in C#, Postgres SQL, Lucene, Python, and Excel
  * Building client-facing features in React, Typescript, and Django
  * Interfacing with CoreNLP, NLTK, spaCy, Accord.net, word2vec, numpy, and tensorflow.

Drop Matthew a hello @ founders@motionhall.com

>Norman H. Cohen (nco...@watson.ibm.com) wrote:

Anyone know what the watson group at IBM was doing in 1995?

Do you have any more? Looking for an invite :)

The C# documentation is quite clear: https://realm.io/docs/xamarin/latest/

  var puppies = realm.All<Dog>().Where(d => d.Age < 2);

The LINQ integration is appreciated.

  // Update and persist objects with a thread-safe transaction
  realm.Write(() => 
  {
      realm.Add(new Dog { Name = "Rex", Age = 1 });
  });

  // Queries are updated in realtime
  puppies.Count(); // => 1

I'm assuming that "updated in realtime" means "realm.Write is a blocking operation", correct?

Life aside, in a slightly different universe, it's unclear whether space or chemistry or atoms would even be possible: https://en.m.wikipedia.org/wiki/Fine-tuned_Universe

To quote neutral milk hotel, "how strange it is to be anything at all"

To extend this even further...

~This~ morning Joe rolled a dice, and it came up 1, so he hosted a board-game party.

During the party Joe hints that the die he rolls may be very large, but stops short of outright saying so.

Joe also refuses to say whether he rolls the die every morning, or if it was just this morning.

The interesting questions are:

How big is the die?

How often is it rolled?

Does Joe do anything at all if he rolls almost anything other than a 1, or does he just lie in bed?

If the very large die is only rolled once, and all non-1s are very boring, then it is remarkable that we're here.

Does YC still require international corporations to reincorporate in Delaware?

(for those unfamiliar) With roughly even strength, Isreal destroyed 82 Syrian aircraft + 30 SAM batteries while suffering only 2 damaged aircraft (that flew home).

https://en.wikipedia.org/wiki/Operation_Mole_Cricket_19#Batt...

>Socrates, Buddha and Confucius we're alive at the same time, yet we don't call that "age of philosophy".

Actually we do: https://en.wikipedia.org/wiki/Axial_Age

>During this time, according to Jaspers' concept, new ways of thinking appeared in Persia, India, China and the Greco-Roman world in religion and philosophy, in a striking parallel development without any obvious direct cultural contact between all of the participating cultures of the Old World.

I'm in the same boat. The only machine I can find fitting those specs at the 13" form factor is a Clevo W230SD[1]. And I have serious concerns about its build quality.

[1]http://www.xoticpc.com/sager-np7339-clevo-w230sd-eta-0320201...

For those interested, I think Whisper Systems is currently hiring iOS + UX in the Bay Area: https://news.ycombinator.com/item?id=9127708

Super cool!

We've been running a worker owned, profit sharing contracting company out of Halifax, Canada for about 5 years now. (http://twistedoakstudios.com/about.php). We haven't really dove into the start-up/MVP scene very much, though.

I'm waiting for someone to make a life sampling application.

N times per day, for M seconds, turn on all my phone's sensors and take a short video capture of my computer screen.

Then upload that data (preferably to my own server, not yours).

Every couple days, I'll log on and tag the data. At 17:56 on 12/05, I was sleeping, working on X, talking to Y, going to Z, etc.

Sample 3-4 times a day for a year. Should get a really clear and interesting picture of your life after 3 months or so.