Sigma is a huge supplier to the sciences; you can (with 40,000 pages of DEA approval) get just any chemical overnighted to you. For instance, you can order a Methamphetamine/Cocaine/Heroin solution (all in acetonitrile):
113 karma · joined February 5, 2015
Fighter jets were there immediately, people tried to talk him down, and he was lost. Nothing better could have been done all around. Yes, commercial planes could be keycoded or controlled in some other way, but I think most engineers in a controlled setting will agree this creates exponentially more day-to-day headaches than catastrophic situations it prevents.
http://www.nature.com/news/embryology-policy-revisit-the-14-...
Will be interesting to see the moral and ethical debate on any change here.
-User designed sequences (maybe I just couldn't find it). Everyone wants to drop their primer of interest in, their unique tag, their CRISPR site, etc. Also, some well-balanced GC spacers would be helpful, even make them unique so people could PCR off them if needed.
-Barcoded sequences. This will ruin / complicate the auto IDT pricing, but a nice drop-in feature would be a degenerate barcode sequence. This is all the range with MPRAs or other high-throughput methods, and could be really helpful
-Architectures. Say I want to design a lentivirus construct. Give the user the scaffold to drop their payload in, with set LTRs, etc. Screen for no polyA signals in their design, etc. An easier way to walk novice users into design (maybe best not to start with lenti...)
Anyway, keep up the good work, it's a cool product!
To echo the old thread's sentiments, I'd be extremely happy to see this hit the market in late summer as a great full-page PDF viewer. Academics would never be happier. Just hoping it's not vaporware like so many others.
On the other hand, figuring out what variables to control is huge part of science. Say the development of next generation DNA sequencing technologies. People tried a ton of different variables, conditions, reagents, flow cells, etc. And failed and failed. But eventually they controlled the right conditions, optimized the right things, and now the process is done in thousands of labs every day as a routine tool. This is a technology development example, but the same could be said of the conditions needed to make stem cells.
http://www.genomebiology.com/2001/3/1/comment/1001
With the great quote:
"...If a hundred years of cancer research has taught us anything, it is that if you must get cancer, you want to be a mouse, because we can cure cancer in mice."
http://www.nytimes.com/2015/10/03/opinion/the-folly-of-big-s...
http://sandwalk.blogspot.com/2012/01/whats-difference-betwee...
Although the 3D plots are neat, they kind of feel like 3D barcharts: they add very little over a more straightforward representation (like a heatmap instead).