hentrep

Garriot’s autobiography was one of my favorite reads from 2018: https://www.amazon.com/Explore-Create-Pursuit-Frontiers-Crea...

"Any observed statistical regularity will tend to collapse once pressure is placed upon it for control purposes."

Source: https://en.wikipedia.org/wiki/Goodhart%27s_law

The presumption in your comment is that evolution selects for brain traits which confer some sort of advantage. This ignores the fact that the modern human brain is used very differently than that of our ancestors thousands of years ago.

If you click the Reader button in the upper left of Safari, it fixes this issue.

He has publically stated that there is significant financial incentive for whoever finds the chest to report that it has, in fact, been discovered. Presumably some sort of IOU note contained within?

Here is a fantastic podcast describing Fenn’s story: http://www.eisradio.org/item/003/

Just to clarify, assault rifles are select fire and NOT purely semi-automatic.

https://en.wikipedia.org/wiki/Assault_rifle

In my lab experience, electronic lab notebooks were incredibly bloated, slow, and buggy to the point of being unusable. I’m most familiar with what was in place at Merck about 8 years ago: ELN (Electronic Lab Notebook). I agree with comments that the countersignature is both lax and absolutely necessarily from a records perspective. Most importantly, building a new lab notebook system would require importing data from whatever it is you’d be attempting to displace. Lab notebooks have significant roles in IP disputes, and it would be critical that the contents and timestamps are preserved.

To underscore how terrible ELN was at our site, many managers instructed their reports to keep traditional paper notebooks, photograph each page, and upload to an ELN entry. Countersignatures were then performed on the ELN platform. This was at a relatively small Merck site, and maybe the issue wasn’t as pervasive elsewhere.

Different tumor types have different tumor DNA shedding rates -- this has impacts on test sensitivity. A false negative is not great when dealing with a cancer diagnostic. Additionally, and more challenging, is the variant classification problem. Not all mutations are created equally. Some are pathogenic, some of benign, and some have unknown significance. If you simply report the genetic alteration, and I believe this is the approach taken by Guardant, the onus is on the oncology care team to determine whether the alteration is clinically relevant and actionable. Companies like Myriad and Foundation Medicine provide guidance on alterations which makes this less of a problem. The alternative is for a caregiver to do homework on the alteration and determine whether it is meaningful (through a literature search or ClinVar database query).

Variant classification alone is an incredibly challenging problem. Oncologists are not geneticists, and most hospitals do not have in-house geneticists. Additionally, there is potential liability involved with mischaracterizing genetic alterations.

Sure, that makes sense, but this will undoubtedly result in less savvy folks (i.e. the elderly) being scammed. I suppose I was really looking for a way to escalate the complaint.

Given the high profile attacks on crypto exchanges over recent years, how much trust do you place in Gemini securing your SSN, proof of ID, and proof of address?

A grainy 80-year old photograph of a woman's back seems hardly compelling. The other pieces of evidence they cite seem equally unconvincing. Maybe I've turned cynical given the current mainstream media circus, but this appears to be more of an advertising piece for the mentioned History channel special. It is glossed over in the article, but I'd be more interested in learning about who took the picture, and why he/she did not report seeing Earhart.

This is a great move toward biomarker-driven, tumor-site agnostic targeted therapies in oncology. I attended ASCO 2017 last week, where LOXO showcased data from larotrectinib in a variety of adult and pediatric indications with Trk-fusions. The waterfall plot is fairly impressive, and I'd be shocked if this drug was not the next to be approved across cancers based on biomarker status alone. A decent summary about it here: https://endpts.com/loxo-takes-center-stage-at-asco-with-its-... Company presentation here: https://www.loxooncology.com/docs/presentations/Hyman_Larotr...

Love the concept!

I'd be interested when/if this launches on iOS. Perhaps add an email capture to the landing page?

Link to his Reddit AMA yesterday: https://www.reddit.com/r/IAmA/comments/64sark/i_bought_a_hou...

You alluded to this with mention of interest in a leadership position at work, but what are your near-term goals in life? Make a list, devise a strategy, and focus a portion of each day stepping toward those goals. Be careful and explicit in drafting these goals. For instance, "Become wealthy" isn't as clear and actionable as "Increase my income by $500 per month."

Are you focused too much on work? When is the last time you took a week or two off just to mentally reset? How is your social life? I was interested in a specific field a few years back, but I had zero friends or connections in said field. I started a meetup group around the topic, grew it to 1500 members in just over a year, learned a TON about the field in the process, and made invaluable and exclusive connections that would have been otherwise very difficult. It was a beautiful blend of social and professional advancement and I highly recommend something similar.

Last point: if you're considering grad school, be aware that this is much more accessible and palatable early in your career vs. late. If you have a shot at getting into an MIT or Stanford, why no give it a whirl? It isn't necessarily the degree that is of value, but the high-end network you'll obtain in the process.

Keep your head-up -- motivation will ebb and flow throughout your life. This is normal and a sign that change is in order.

I work in pharma, and our biggest bottleneck is drafting and executing service agreements and statements of work with new vendors. A system to facilitate this workflow would be amazing (document templates, a queue for requests with weekly status updates, etc.)

Of course there is manual work done by Legal that can't be easily automated, but that is just one component of the bottleneck.

I don't think this is the recording you refer to, but here is an audio version of Exhalation: http://escapepod.org/2009/04/10/ep194-exhalation/

I haven't used Google Flights -- will check it out -- but have taken a similar approach with Skyscanner.com. Basically, if I want to filter a trip based on price without regard to location or travel date. Really fun to play with!

I was under the impression that Alex practices each free solo route multiple times while roped.

I'm by no means discounting his accomplishments and skills, but rather highlighting that it isn't quite as reckless as it first appears.

Is anyone aware of a spaced repetition app for iOS that allows you to enter content via a web interface? Most of the flash card apps I've seen require you to build out cards from within the app, which is tedious and clumsy.

Most rental car companies (Budget, Enterprise, Thrifty, etc) require a deposit which is held against your credit/debit card. It's typically >=$200, but they usually require a larger deposit if you use a debit card. I've been required to put down $400 in the past. They often don't make this deposit obvious, but you will definitely see it reflected in your card's account activity.

Would genuinely love to hear about companies that don't require this deposit.

I've recently gone through a similar situation/realization. The panic and desperation is normal and ephemeral. A short, unplugged break from everything can be a godsend (I spent a week road tripping through Northern California). If you're in the Bay Area, I'll gladly buy you a couple of beers and we can trade war stories.

Though I haven't done business with them, I ran into the team from Crowdcurity (now cobalt.io) at a bitcoin meetup a few years ago. Seemed like very solid guys, and their approach toward security was intriguing enough.

How would you propose we incentivize drug companies to spend $1B and 10 years in development/time costs (in the oncology space, for instance) if there is no IP to protect that investment?

Drug development is hard, expensive, and littered with failure. There isn't a simple approach to this problem.

As others have mentioned, this all occurred before the AK-47 was put into production. I believe the Mosin-Nagant 91/30 was standard issue for Soviets in WW2.

It should be pointed out that most US-based oligo synthesis companies will screen orders for potentially "dangerous" sequences. I recall watching an IDT (idtdna.com) video on CRISPR that brought this to light.

As far as I can tell from the Indiegogo video, Amino appears to be a simple bioreactor that includes competent cells + some sort of plasmid to express genes related to bioluminescence -- am I missing anything else? Pretty compact and neat; I would have loved to play with one of these as a child.

First time I've seen someone TLDR at the top of an article. Wish more articles would do this -- thanks!

I know nothing about the investment world, but find this government-driven investment interesting. Last week the Canadian Pension Plan Investment Board, in participation with Permira, agreed to take Informatica private [0]. Two large tech investments by Canadian pension funds, and likely many more to which I'm unaware. Is this a proactive move to mitigate future pension crises [1], or just the way most governments operate? I suppose I'm not accustomed to thinking of governments investing in this manner.

[0] http://www.nytimes.com/2015/04/08/business/dealbook/informat...

[1] http://en.wikipedia.org/wiki/Pensions_crisis

It's certainly better than the alternative in some places, which is zero internet. Look at how widespread "dumb phone" use is throughout Africa. Some incredible and empowering things can happen when unprivileged folks are given what we might consider outdated technologies.

Video of the formula being read aloud: http://io9.com/5961395/a-3-and-a-half-hour-video-of-the-worl... Pastebin of the formula: http://pastebin.com/wkKH8xD8