hentrep

Source? Would love to read more about this.

A 2023 audit of the LAPD air support division showed a nearly $50M annual cost [0]. I'd wager most of these activities could be performed more quickly and effectively using drones. Presumably this is an issue with most urban police departments across the US.

[0] https://controller.lacity.gov/landings/lapd-helicopters

Comparing the acceleration of FDA approvals for non-contagious terminal diseases like PDAC to development of COVID vaccines is flawed on so many levels. You make it sound as though this was just cooked up in some desert meth lab RV over a weekend, and the FDA just rubber-stamped after a cursory glance at the data. The Phase 1/2 study first exploring daraxonrasib (RMC-6236) was posted on clinicaltrials.gov in May 2022; this trial enrolled 754 patients [0]. The RASolute 302 study this approval is based on was first posted to clinicaltrials.gov in October 2024; this trial enrolled 500 patients [1]. Nevermind the years of preclinical discovery and translational work that had to precede human studies.

As you can see from the control arm showing 6.7mo of survival on standard of care chemotherapy, these patients have a very poor prognosis. Is this a cure? No. Does it buy time to see your child graduate, get married, or give birth? Quite possibly.

If you ever have the opportunity to work behind the scenes within the pharma industry and/or FDA, you'd be astonished that anything ever gets approved with all the red tape and complexity along the way. Medicine is not software - it operates within the black box of human biology which is incredibly nuanced from patient to patient.

Like many who have shared personal stories in this thread, I've lost friends to PDAC. It is a terrible disease often driven by a mutated oncogene (KRAS). Many cancers have KRAS-driven subtypes (lung, colorectal, low-grade serous ovarian, etc). The clinical platform and pipeline at RevMed has potential to address many other cancers. They have next-gen RAS agents that could be even more impactful.

For those curious, RevMed posted a solid summary of the approval on their IR site [2]

[0] https://clinicaltrials.gov/study/NCT05379985?tab=researcher [1] https://clinicaltrials.gov/study/NCT06625320?tab=researcher [2]https://ir.revmed.com/static-files/0f7e4612-ad39-4c87-b266-8...

Beyond the data, this approval is notable for the speed from FDA acceptance of their new drug application (NDA) to FDA approval - just over a month. Compare this to the typical 8-12 month timelines we've historically seen for priority and standard reviews, respectively. This was enabled by the FDA's CNPV Pilot Program [0]

Previous discussion following the data presentation at ASCO: https://news.ycombinator.com/item?id=48517199

[0] https://www.fda.gov/industry/commissioners-national-priority...

Beyond the data, this approval is notable for the speed from FDA acceptance of their new drug application (NDA) to FDA approval - just over a month. Compare this to the typical 8-12 month timelines we've historically seen for priority and standard reviews, respectively.

Previous discussion: https://news.ycombinator.com/item?id=48517199

FDA press release here: https://www.fda.gov/news-events/press-announcements/fda-appr...

Here’s the original manuscript: https://www.frontiersin.org/journals/neuroscience/articles/1...

Seems related (though 2 months delayed) to this announcement: https://news.ycombinator.com/item?id=45961157

Maybe this is interesting to some. I stumbled upon this link in Spotify’s privacy policy and found the stats surprising. In 2024, Spotify processed nearly 30 million user requests to opt-out of data sharing for tailored ads. Additionally, they received 7.5 million requests for deletion (presumably accounts).

I’m sure there’s legal rationale for the transparency, but I found the opt-out requests surprisingly high. Per their 4Q24 earnings [0], they reported 675 monthly active users, so a roughly 4% opt-out rate. I’d have never guessed 30 million people worldwide were that privacy-conscious.

[0] https://newsroom.spotify.com/2025-02-04/spotify-reports-four...

I submitted this link to HN with the Reddit title in quotes. Not sure why the quotes were removed, but I want to clarify that I am not the Reddit post author.

Long time BirdNET fan, but I used the Merlin app for the first time yesterday and found it much more useful [0] It’ll display multiple bird species at the same time, and highlight which song belongs to which species in real-time. Recommend giving it a shot if you haven’t!

[0] https://merlin.allaboutbirds.org/

This is a bummer - headed to Berlin for the first time in a few weeks and hoped to visit. Any recommendations for similarly geek-oriented side trips in Berlin?

Looks like mbforbes posted this project back in 2024 [0]. Neat to see things come full circle!

[0] https://news.ycombinator.com/item?id=40091379

Sounds like it would be a fun experience!

I know this comment was made tongue-in-cheek, but I'd argue the use-case depends on where you live. There are many crime-ridden areas within the US that are hostile toward homeowner defense in case of a break-in. Additionally, these areas are often under the jurisdiction of understaffed or demotivated law enforcement agencies.

I'd prefer having a robot serve as first-line of defense for home invasions versus me confronting an armed burglar while half-awake in my underwear. Despite burglary alarm systems, response times are often laughably delinquent.

I live in an area where the median home price is 7 figures (it's mostly expensive land rather than opulent homes). My neighborhood averages at least 6 home invasions per year. These aren't performed by your average criminal - they operate in sophisticated groups that employ WIFI jammers to knock out security cameras before breaking in. This is a significant issue across other areas of the US.

That said, I'd prefer a robot with both defensive and home assistant capabilities :)

Curious - what’s your use case?

For me, the interesting aspect of this is that knowledge workers can stretch another 20+ years out of their careers vs. professional athletes. How long until we see a W9-minted billionaire?

Unfortunate for the obscure source here - more established outlets are behind paywalls (Wash Post, Bloomberg, Reuters, etc.)

Presented during the ASCO 2025 meeting in Chicago. Conclusions:

“CONCLUSIONS

A 3-year structured exercise program initiated soon after adjuvant chemotherapy for colon cancer resulted in significantly longer disease-free survival and findings consistent with longer overall survival.”

Is anyone aware of data on how many foreign grad students remain in the US post graduation, versus seeking employment outside?

I've long wondered whether working within AR glasses improves one's ability to focus. My hypothesis is that I have fewer shiny objects in my periphery to create distractions. Can anyone who has experience with AR glasses comment?

If Masimo sounds vaguely familiar to folks, it’s because they sued over the Apple Watch blood oxygen sensor, ultimately resulting in it being disabled in the product.

https://www.macrumors.com/2024/11/05/masimo-apple-california...

Disclaimer: Not a doctor.

I think you’re alluding to this in your last statement, but standard treatment for Lyme can absolutely wreck your natural gut microbiome. This could explain some of the lingering chronic effects post-treatment. Did you try supplementing with fermented foods or probiotics after completing dox?

The discovery of rapamycin is such a fascinating story. Radiolab covered this a few years back - I encourage everyone to give it a listen: https://radiolab.org/podcast/dirty-drug-and-ice-cream-tub

Link to primary manuscript: https://www.nature.com/articles/s41467-025-57263-1

Caveat: Single-arm Phase 1 trial of just 21 patients.

Graphical abstract in the supplementary materials: https://static-content.springer.com/esm/art%3A10.1038%2Fs414...

Curious as I’m of the same mind - what’s your local AI setup? I’m looking to implement a local system that would ideally accommodate voice chat. I know the answer depends on my use case - mostly searching and analysis of personal documents - but would love to hear how you’ve implemented.

Ah, thanks for clarifying!

He does the same redirect whenever someone links to his DNA Lounge: https://dnalounge.com (NSFW)

I noticed the URL was updated for this post. Previously it linked to asahilinux.org which showed an anti-HN manifesto from the HN referral. Curious as I haven’t seen this before. Seems it has been covered by previous commenters: https://news.ycombinator.com/item?id=36227103

Here’s the actual USDA article describing the difference between “sell by, “use by”, and “best by” terms: http://www.fsis.usda.gov/food-safety/safe-food-handling-and-...

I don’t have time to find a source that supports this, but I understand that these dates also refer to the durability of the “food safe” container/packaging. Ever drink water from an unopened plastic bottle that has been stored for awhile? That taste is not from the water decaying or otherwise breaking down.

>Surprising that there isn't a 'hey siri' for chatgpt yet

Sort of a middleman approach and certainly not perfect, but you can invoke ChatGPT with Siri using Shortcuts.

https://help.openai.com/en/articles/7993358-chatgpt-ios-app-...