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Cardiology fellow here. The more you have to pace the shorter the battery lasts? Struggling to see what the novelty is here.

People have been doing this for literally decades. Check out work by Tattonetti

This is most likely a good thing. It isn't killing cardiac myocytes, it's probably assisting with reverse remodeling. Fits with why we know it helps in heart failure.

You have no idea how a hospital or modern medicine works. It needs to be online.

Because essentially every large hospital in the USA does?

None of these works nearly as well as angioplasty

Just wrong. Read about the 7J7. The 787 cost something north of 20 billion to develop. The clean sheet 737 would have cost much more in today’s dollars. Boeing makes an average of less than 5% profit margin from the 1970s to now. It was a relatively obvious financial decision from Boeing’s perspective.

Shame on you.

We will not have supersonic transport for average people unless outsiders do it first. There are only two meaningfully large manufacturers now, Airbus and Boeing.

Boeing and Airbus both cannot financially afford a technologically promising but possible failure now. Boeing built the 737 MAXX because they couldn’t afford a clean sheet update of 70-year old technology despite the savings. Airbus lost almost as much as the entire company was worth on the A380, kept afloat by EU subsidies.

All new technology happens for the wealthy first - we would not have smartphones today if Apple was forced to price them at the median price of cell phones in 2004.

This has been beaten to death in high quality randomized controlled trials in sepsis. Don’t believe a university press release lol. HN is a pretty poor source of health information overall.

This is a simplification. For example niacin (vitamin B3) excesses cause cholesterol to become more atherogenic. And supplementation in patients without deficiency is ultimately harmful.

Your pancreas actually does know things like that you've ingested a lot of carbohydrates before they enter the bloodstream, etc. Certainly there is also a response to exercise that occurs before you coiod easily detect it with a CGM. There are very complex brain-gut-pancreas interactions mediated by a variety of molecules/hormones.

> Hypoglycemia becomes symptomatic long before blood sugar is low enough to result in death or serious debilitation and T1D patients know their symptoms well.

Often times in an acute setting, yes. However patients who have had diabetes (T1 or T2) for a long time often lose a lot of their hypoglycemia sensitivity and symptoms. It's not nearly that simple.

I believe that most of the lead used today is a by-product or co-product of mining other more valuable metals like Zinc and silver. Lead is quite abundant in the Earth's crust and found in easy to access deposits.

I think >80% of the current industrial use of lead is for batteries. It's probably still in the top ten most mined metals by dollar value and definitely by mass.

Fascinating. Thank you for sharing. I’m glad you were able to arrive at a diagnosis. I’m sorry to hear it was such an odyssey. I wonder how many other patients like you we are missing.

Thanks for sharing. I’m a doctor. If you don’t mind sharing, out of curiosity how were you diagnosed with this? Not one of the primary immunodeficiencies I see tested, but I’m not a medical geneticist or pediatrician.

It is not allowed prior to purchase

What even is a developer MacBook? Any applied computer can be used

Interesting he calculates the theoretical maximum for efficiency will be around 260 MPGe

Addressing his specific point that “decolonization” of the curriculum in medicine is “dangerous” - As a practicing physician, I strongly disagree. I think the author likely has a completely inaccurate idea of what a medical curriculum even is, as I cannot reconcile most of what he is saying with what I’ve seen at several of the top medical training places in the country. Decolonization of medical curriculum in general is important as our euro-centric view of disease often ends up dramatically hurting minority individuals. This runs from obvious things like making sure physicians have pictures of rashes on melanotic (dark) skin in textbooks to more difficult things like incorporating non-European ancestry individuals in massive genetic studies and not simply discarding their genetic info (as has been done for a lot of large population studies historically).

For the specific task of (for example) cooking a steak it’s not hard to envision a computer vision algorithm coupled with a model with a some basic knowledge of the system (ambient temperature, oven/stove temperature, time cooking, etc.) doing an excellent job.

This was the basis of a very famous F1 car in the 1970s. It was ultimately banned.

Use of the CDC dataset as controls for a non-randomized trial is very problematic. Hard to know what to make of this at all. It has a modicum of bioplausability but I don’t think my posterior probability estimate of effectiveness has changed at all after reading the paper.

Truly an unnecessary dig at oncologists. If that happens it is not frequent. The more relevant association for clinical oncologists would be ASCO, which has its annual conference in Chicago this year.

I don’t fully understand the appeal from the manufacturers’ side for in-home batteries and solar. We don’t expect houses to have their own coal powerplants or nuclear generators; why is renewable energy different?

Single family housing is becoming a smaller segment of the market as time goes on; those who rent apartments or own condominiums have little say in how their electricity is delivered as well.

The problem with this study is that the analysis is based upon intention to treat. Only 42% of those who were randomized to get a colonoscopy actually got one. The cancer incidence was 18% lower among all people who were invited to get a colonoscopy. If we assume rate among people who were invited to get a colonoscopy but did not go through with it is the same as the rate of people who did not get a colonoscopy then the cancer rate would be more like -2/3 among those who got a colonoscopy.

This is a week old. Emirates did agree to cap passengers: https://liveandletsfly.com/emirates-heathrow-compromise/

There is also some mouse experimental data

That's not true at all, though. Y9u can absolutely do that as long as it's not in red and grey and sold in places customary to collegiate athletics.

Fascinating observation. Thanks for sharing. Given that this problem space still exists I wonder what the best approach might be other than taking the mean

Nice. Yeah maybe this will be a win. I’m overall more for it than against it. Just think there are some downsides. Glad to hear you have had a good time on the NY State insurance. Is it Medicaid? Langone actually has the best (most private) payor mix of any of the hospitals in NYC, I believe primarily from geographic reasons. Did you get to compare to Bellevue at all? Curious on your perspective there. Hope you’re doing okay.