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first at last dot com
[1] http://daringfireball.net/2012/09/timing_of_apples_map_switc...
Project Glass is definitely interesting, as another commenter mentioned.
Apple, for example:
http://store.apple.com/us/product/H8332LL/A/square-credit-ca...
First off, a human settlement on Mars, while technologically challenging, would need a relatively small initial population to get started sustainably (say, 2000 people). All of the advancements in food and energy production mentioned in the article could be used to provide for a colony there.
The OP talks about genetically engineered animals for food production, but they could also be engineered to better work and thrive in space-based industries; collecting raw materials, zero-gravity manufacturing, energy collecting, etc. Sophisticated, autonomous machines could do all that as well, so that actual humans have very little need to spend much time out in space, other than traveling between planets and settlements. Or perhaps all travel is virtual, using telepresence to see the solar system.
Machines built in space don't have the costs to get up there in the first place, other than the initial factories and material harvesting equipment.
Great thought-exercise, though. I love thinking about this stuff, and I think our generation has to start anticipating these changes. Some other commenters pointed out this all may happen far sooner than 500 years, so we just might need to be ready.
Very interesting look at Siri's potential (via everyone's favorite Gruber): http://counternotions.com/2012/11/12/siri-future/
http://tv.msnbc.com/2012/11/06/machine-turns-vote-for-obama-...