L_Rahman

'Sometimes even newspaper critics' - oh man this is harsh. I don't like the biases that newspaper critics tend to have but Pete Wells and Ruth Reichl at the Times, Sietsema (previously at the Village Voice, now at Eater) all do excellent reporting.

But I agree that it all pales in comparison to amateur enthusiast communities and specialist blogs.

If Twitter can't figure out a way to build a platform that does not damage society without violating First Amendment protections, then perhaps Twitter should cede its responsibility to the platform but opening the social graph up to let anyone build any version of it on top.

You're not a weirdo. This is something I feel similarly about, but here's the thing about rich people:

1. The path to becoming rich puts them in a social class that warps their view of what matters and leaves measuring themselves against arbitrary hierarchies of their own making.

2. The path to becoming rich in modern society is such that the kind of people who would commission RISC-V implementations or security audits of popular open source software or cheap medical interventions simply cannot succeed. It may require too much of a compromise of those beliefs to actually win.

It's not for urgent transit. They're probably trying to take a cut of the transportation voucher program available to seniors and those with disabilities to access subsidized rides from existing services.

http://web1.ctaa.org/webmodules/webarticles/articlefiles/Rur...

I promise you that most New Yorkers are deeply unhappy with the subway.

The pride that we feel in the MTA is in carving out a non-automobile based way of life in a country where the ability to drive and own a a car is synonymous with independence and coming of age.

We're also a little proud of the fact that it never stops running even if the trains are only running every twenty minutes. I can not describe how freeing it is to not feel bound by a metro closing time (as I so often do when I visit London or Seoul or Hong Kong).

When I first read the grandparent post, I thought it was a deliberate choice of words to denigrate "the cloud" but the fact that it's the accidental result of an overzealous browser extension in a thread talking about dysfunctional technologies makes this incredibly funny.

They're starting to resolve this in some stations. Many Manhattan subway entrances now have boards above them showing the arrival times for the next two trains.

I am one of the Matt Levine readers who thinks that this nationalization would be an interesting path towards American socialism.

Edit: also /u/aomurphy I'd love to chat about your "information stack" so to speak. If you're interested - my email is in my bio.

Presumably to avoid any impression of special collaboration between Google and Motorola that would have spooked the large Android OEMs of the time - Samsung, HTC and LG.

Healthcare companies are getting rich.

http://slatestarcodex.com/2017/02/09/considerations-on-cost-...

there is clinically proven evidence that seeing the same provider in the same setting improves outcomes:

https://www.newyorker.com/magazine/2017/01/23/the-heroism-of...

Fellow alum here, most engineering majors still have a similar design project as a significant chunk of how they spend senior year.

For mine (I was a biomedical engineering undergrad) we built a computational model of the metabolism of HIV drug cocktails are various dosages modulated by factors like age, weight and phase of HIV infection.

Yes, left-handed notebook nerds!

I'm a loyal Lleuchtturm user, but have been considering the Midori notebooks. How do they compare?

My uncle is one of those people who sits in subway booths. He does almost nothing.

He makes 80k a year.

My political ideology is deeply in favor of the working class. I believe in strong worker protections, in the unionization of labor in most industries, and that capital controls a disproportionate amount of wealth and power in this country.

But I must also insist that these costs are unfair and insane.

I promise you that New Yorkers care about this deeply.

https://comptroller.nyc.gov/reports/the-human-cost-of-subway...

Any survey of New Yorkers and government services will tell you how much this matters.

The biggest problem is that the New York government at city and state levels is one of the most corrupt, oligarchic and undemocratic organizations in modern society. I cannot begin to describe how broken it is.

Here's a good example: https://www.nytimes.com/2017/09/18/nyregion/new-york-politic...

This leaves us with no levers of power over government decisions. When you take into account that the people who most heavily depend on the subway are also the poorest, we have even less power over the elected and appointed government class.

The absence of other people outside your community was not an accident. Members of the government, of financial institutions and urban planning departments made deliberate choices to exclude certain types of people:

https://www.theatlantic.com/magazine/archive/2014/06/the-cas...

https://www.npr.org/2017/05/03/526655831/a-forgotten-history...

At a lower level, this is the game everyone who participates in "access journalism" is playing. Journalists and publications build relationships with sources and report stories keeping one eye on the writing/impact/truthfulness and another on the long term relationship with the sources.

That's the implied norm of institution (business/government) relationships with the media - we maintain relationships, you write about us and some stories will be critique us so we'll soft cut your access off for a little bit but not explicitly and then we'll let you in again.

An example would the one you yourself made. Journalists join the White House press corps, and over time get access to various West Wing staffers to write stores.

(if you're wondering whether this mechanism contributes to status quo bias and protection of established interests you're headed in the right direction :) )

Access journalism is distinct from investigative journalism which is what we're seeing here. Investigative journalism assumes journalistic independence and a more adversarial relationship with the institution being documented. What we hope to see after an expose like this is the institution coming to terms with its behavior and in response to public outcry, tempering the things that were revealed.

The problem of course is that institutional power in the United States, especially that of large corporations, is so large that they respond to this kind of journalism with aggression.

I don't know whether Disney will suffer for making that choice, but I hope that they do.

This post seems to have brought the concentration of corporate power / regulatory capture HN critics out of the woodwork.

I am so happy to see and read all of you.

> each time anyone passes go, the player with the most money gets to create a new rule. Guess what? The game is gonna get pretty skewed, pretty darn fast.

We call that crony capitalism and it is very much the opposite of a free market. I do agree with you however that we don't have effective barriers between money and government (or other forms of) power and therefore the stable state for liberal democracies with capitalist markets is crony capitalism and regulatory capture.

I can confirm that the foreign SIM card override works from my experience a couple of years ago.

My T-Mobile had free international roaming baked in at 2G speeds. Unlike the US however, most foreign carriers in developed Asian nations (China/Korea) don't support 2G fallback, so I had free 3G everywhere.

It was pretty much like using the American internet.

Most likely a drone mounted stingray device with find/follow capabilities:

https://en.wikipedia.org/wiki/Stingray_phone_tracker

This is a fair response and one that lifts from "disruption" like thinking processes.

I've made a personal decision however to retreat from "realpolitik" like political analyses because it requires me to play mind games about the probable intentions of the decision maker, their constraints, and the possible outcomes of the decision they made.

Holding people to a set of normative values that I believe to be meaningful has been a more useful (if more blunt) meta-construct*

* this conversation has me wondering if it might be time to revisit that position

Ha, a fair criticism. I was aware of the distinction, Salman seems to be sovereign in name only these days which is why I took the liberty of framing MBS as the decision maker:

> The question now arises: Will the king abdicate the throne and turn power over to the son he clearly trusts? Serious newspapers have raised the possibility. King Salman has already given his son unprecedented power. His nickname is Mr. Everything because he has been given control of the military, the economy (including the oil industry), and even control of the entertainment business. He has been the de facto foreign minister for the last two years, conducting all the important foreign policy issues and visits, including setting up President Donald Trump’s historic visit to the kingdom. He will presumably represent Saudi Arabia at the G-20 meeting in Hamburg.

Salman is 81 and suffers from pre-dementia. The state of his health is a closely guarded secret. He has been very busy this year, with a month-long trip to Malaysia, Brunei, Indonesia, China, and Japan, plus attending the Arab summit in Jordan, as well as hosting Trump and 50 Muslim leaders. So he, apparently, is capable of being in power for some time to come. His brothers have often lived into their 90s.

Since the person behind this project is the sovereign of a nation-state, perhaps they should build a new way of living in their existing cities and society.

A good place to start would be enshrining basic civil liberties and not bombing civilians in a neighboring country.

SaaS is essentially an acknowledgement that the most profitable and extractive business model in modern capitalism is to build a capital intensive product and rent it out.

With software there is the added benefit of low-cost, highly scalable replication of the capital intensive product.

It's difficult to imagine because there has been a not widely acknowledged rise over the last twenty years of incredibly well-resourced parents who spend all of their available time, energy and money on their children.

Elite education (Ivies, Stanford, MIT, Chicago, Hopkins) historically was almost entirely the playground of the already rich. From the 70s onwards, it became a competitive game for the working upper middle class to send their children there. This elite stamp was necessary for their children to at least maintain working upper middle class status but ideally they'd collide with one of the already rich kinds and enter the wealth not labor class.

As income inequality has grown, admission to these institutions have grown even more valuable and parents have dedicated even more resources to giving their children a shot.

The result is that the children of well educated professionals end up in incredibly well resourced environments at home and in their schools. For context, the neighborhood this girl lives in has a median family income of 109,000 dollars, is 91% white and has only 2% of its population living below the poverty line.

Thanks for putting the links together.

If I understand this correctly (my biomedical engineering undergrad finally coming to use!):

1. Cancer cells present antigens that are specific to cancer cells and do not occur in healthy cells.

2. CRISPR allows us to genetically engineer someone's existing T cells to target those antigens.

3. When re-introduced, these T-cells target the cancer cells and destroy the tumor.

4. Because they are T-cells, they're effectively distributed through blood to the entire body and are able to affect cancerous cells that may be too small to observe or detect.

5. They become inactive and stowaway in the lymphatic system but if the cancer comes out of remission, an "immunity" type response brings them back.

This is amazing. This feels like science fiction from my childhood and the life changing possibilities unlocked by CRISPR that I was taught in my undergrad classes.

Hi /u/toufka, do you have any papers or summaries of CAR-T you'd recommend?

The first-level Google results are all PR-heavy so I'm hoping you can share something more granular and explanatory.

Turns out to be logistically challenging in many ways (and fraught with the socio-cultural complications one would imagine in a tradition going back thousands of years):

https://www.theguardian.com/cities/2015/jan/26/death-city-la...

I was about to type this depressing sequence of roadblocks myself so I thank you for already having done this.

The drug development ecosystem in America makes me sad.