this is called cold welding
334 karma · joined March 10, 2021
Hassan-i Sabbah's militant group was known for taking drugs (hashish) as well as the targeted murdering (assassinations) of key figures during the Crusades. So they were referred to as hashishins (arabic for hashish-smokers) which was eventually turned into assassins and thats where the term comes from.
Even if the challenge was just "recognize MHC-presented cancer antigen" in therapy you have to a) determine what section of the mutated protein would be displayed in MHC, b) determine and develop an antibody (or antibody-like molecule) how to recognize specifically that (and not the non-mutated version which will be present in healthy cells), then c) either genetically engineer the patient's immune cells to recognize it, or hijack the recognition process in some other manner.
Each of these steps is very very difficult and we're only just developing the computational and experimental tools to do these for any patient, let alone every cancer patient. I won't go into it, but you also have to think about cancer as a living organism susceptible to evolution so if you don't hit hard and fast to wipe it out all at once, you select for mutations that evade your treatment. This is made especially challenging considering that cancer usually has some mechanism gone awry that leads to increased growth and mutation rates so that they're even MORE likely to evade your treatments then a generic cell - think of it kind of like antibiotic resistance in bacteria
Not to discount the work which is amazing and is surely great news for sufferers of myeloma, but when you see mention of technology like this don't get TOO excited that we're on the cusp of a cure for cancer UNTIL you see it happening in various solid tumors.
https://twitter.com/ChrisO_wiki
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I also dream often and vividly and some of the dreams I have had have been so realistic and fulfilling that I wake up in a state of awe, feeling as if I have just lived a wonderful experience inaccessible to waking life. For example, I once had a dream where I traveled to the moon where I woke up feeling, as silly as it might sound, as if I had just returned from the moon - hard to describe how wonderful this experience actually was.
So to answer your question, I think there is benefit in altering your state of mind through dreaming to re-align your perspectives and to get a different view on life. I don't think this requires controlling the subject of one's dreams, but having some control over the quality certainly would help.
[1] https://www.livescience.com/little-known-sleep-stage-may-be-...
Yes an individual should be media literate, just as corporations SHOULD practice fair competition and people should not invest their life savings in Ponzi schemes or kill one another. Unfortunately, maintaining a stable society in the real world requires governance. 16% of the world's population don't have electricity. How can you expect them to educate themselves about misinformation while technology beyond their comprehension is being weaponized against them?
There's also all types of annoying workarounds you have to do while tuples as indexes resulting from it converting to a MultiIndex. For example
srs = pd.Series({('a'):1,('b','c'):2})
is a len(2) Series. srs.loc[('b','c')] throws an error while srs.loc[('a')] and srs.loc[[('b','c')]] do not. Not to vent my frustrations, but this maybe gives an idea of why this change is important and I very much look forward to improvements in the area!
> "Suggesting to the study authors that city life in Milan has provided a stable environment for thousands of years"
This does throw a wrench in prevailing thought that improved childhood nutrition is leading to taller people. I would guess that, when it comes to changes in stature, environment/nutrition are more cataclysmic effectors while genetics vis-a-vis sexual preferences play a more sustained role in shaping it. i.e. in a stable environment you would expect change mostly to be effected by the cultural preference of taller/shorter people.
On cataclysmic effectors - one really interesting study I think back on often[1] is a serendipitous survey of island lizards hind-leg lengths before and after a major hurricane season. Basically, they found that over the course of one year, there was a 6% reduction in the populations leg lengths due to, they claim, the taller ones being unable to hold onto trees during the storms.
[1] https://www.smithsonianmag.com/science-nature/lizards-with-b...
From that article:
Vietnam is currently connected with seven undersea cables: SMW3, AAG, IA, APG, AAE-1, SJC2 and ADC. Besides the recent breakage of the IA, problems with the AAE, AAG and APG cables that have been present since 2022 and early 2023 have yet to be fully resolved.
The SJC2 and the ADC are yet to be officially operational, while the SMW3 cable is outdated and about to be decommissioned.
The fact that Vietnam currently only has one fully functional undersea cable has caused internet speeds between Vietnam and the rest of the world to slow to a crawl.