thenerdhead

I truly wonder how much time and money big corporations waste with these week to month long processes of rating an employee on perceived impact of work. People say it is complicated, but clearly it isn’t.

Interesting they didn't mention the studies of why low-dose gained popularity as some of the initial study amounts were quite high! (up to 1g):

https://www.ctsu.ox.ac.uk/research/british-doctors-study

https://biolincc.nhlbi.nih.gov/studies/cdp/

https://biolincc.nhlbi.nih.gov/studies/amis/

https://www.nejm.org/doi/full/10.1056/nejm198907203210301

I don't know, sorry. I usually get my research directly from a student account / library access and I also get the physical magazines.

I find it pretty interesting that many of these studies happened in 2021-2022, which is after everyone has been infected with covid at least once. Then to not put any correlation to biological cognitive dysfunction, fatigue, or other challenges given most people still work remotely.

i.e. https://www.nytimes.com/2023/11/13/upshot/long-covid-disabil...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715665/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798975/

Pretty exciting given the last type was discovered in 2016.

Science publication here: https://www.science.org/doi/10.1126/science.adi1910

Here's the main takeaway I got:

A fast locality-sensitive hashing-based clustering (FLSHclust) algorithm was developed. This algorithm is parallelized and scales linearly with the size of the dataset, enabling efficient analysis of large sequence databases.

That means it can scale with exponentially growing datasets, discover rare biological systems, provide more options for targeted gene editing, and even lead to novel biotechnologies.

Sounds like a breakthrough to me!

Yes I did. Sorry it was likely a typo.

How does getting paid change things? Many big tech companies "sponsor" OSS in this way and they have project backlogs bigger than the allowed limit on GitHub. https://github.com/orgs/community/discussions/9678

Maybe they were busy fixing other issues?

https://devblogs.microsoft.com/dotnet/announcing-dotnet-maui...

The latter part should really be looked closer at. You cannot simply attach a company’s market capitalization to how funded a team actually is. People constantly overlook that. That’s true at many big tech companies too. The assumption harms just as much as pitchforking.

Title should be "Developer yells at .NET MAUI team and expects to talk to the manager because their bug hasn't been fixed in two years".

I hope people can see the hostile working conditions that many in open source have to experience daily. There is no possible way for a small team to scale with the thousands of issues they get and give every single one the same amount of attention. That is why it is so important for people to upvote and engage in issues. It gives the product and engineering teams a way to gauge priority.

There are much better ways to go about ranting about product defects though. Doing it in this way just encourages people to pitchfork. We all know that pitchforking isn't productive at all. In fact, it hurts more than you think it helps.

And “I Contain Multitudes” by Ed Wong.

Really exciting findings. Especially given that just last year there were similar threads here where many completely rejected the idea that the gut is a second brain. We live in a very exciting time for science. Especially given we have some initial tools for understanding our guts.

we typically use rats for stress tests.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915631/

Sapolsky has been at this for many years. Here's a great talk on one of his older books.

https://www.youtube.com/watch?v=D9H9qTdserM

Especially with regards to his commentary on Selye's theories/lab work with rats.

Makes sense if you've read a good number of books on stress (i.e. Stress of Life, Sapolsky's work, etc)

There was a fascinating article on quantum dots in a previous issue of Science. First time I've ever heard of them.

https://www.science.org/content/article/creators-of-quantum-...

This news makes it even more exciting.

I dislike this type of thinking. Thinking the job will get done by somebody else because it isn’t “your job” is a disaster for everyone. Sometimes you have to play a certain role depending on the dynamics of your team(s).

Product people should read more books like “Build What Matters” or “Escape The Build Trap”. They are much more practical.

Magicians pull sanity out of their hat.

Magicians less likely to do mind tricks.

Magicians are not disillusional after all.

And for my next trick...mental well-being.

Etc etc

So many possibilities and they went with the most boring one.

A once in a lifetime headline and you go with the safe one?

Congrats! Thanks for trailblazing and being transparent to help other central registries follow.

Read Ed Yong's book "I Contain Multitudes". This area has been more/less blocked for many decades and with recent innovations and pipelines we may be able to start finding causal patterns.

Have you done actual GI / microbiome tests before and after to see any cause/effect? Sounds a bit extreme when you could just follow the 4 K's of Kefir, Kombucha, Kimchi, and Kraut over a long period of time.

> Scientists, health care experts, global health leaders, and advocates must stand up at this critical moment, learn more about PEPFAR, and articulate with clarity what the program does and does not do. Now is the time to meet and share information with lawmakers and Congressional staff. Write letters. Speak out. The lives of millions hang in the balance.

It is at risk. 20 years of investment have gone into it. Now, many renowned HIV researchers seem to be pivoting to help covid / long covid efforts, an epidemic within the pandemic. And they are finding it is similar to HIV - the only reason we cannot cure HIV is because the virus hides where the HIV drugs can’t go in. Leading to high inflammation.

Many researchers believe that if we go all in on one of these, it is possible we can make breakthroughs in HIV, ME/CFS, and post-acute infection syndromes (PAIS) in general. I remain hopeful.

We need a real moonshot here for many things. i.e. similar to what long covid is trying right now https://www.nature.com/articles/d41586-023-03225-w

You’d have to read the book to get more context on his sadness of losing his parents and his reflections on being susceptible during that time. A famous quote is:

“Science is not only compatible with spirituality; it is a profound source of spirituality.”

― Carl Sagan, The Demon-Haunted World: Science as a Candle in the Dark

Visits delivered by non-physicians, but charged as if they’re all MDs. Late stage capitalism is great.

There is a solution here but nobody knows about it.

https://www.youtube.com/watch?v=Wi-4WdpKm5E

Also it has been 3 years since that video and even a modern search still has unclear messaging if this thing is even an option to be used today.

Looks like a dev commented in the GitHub issue, but clearly the maintainer of this project had no idea it existed.

Many PMs are lame ducks at companies because they have to "lead without influence" which is extremely challenging in many large companies where incentives do not align and takes time to build if you're good.

Clayton Christensen knew this all too well and calls this sustained innovation. In other words, to just make incremental improvements to a product to maintain a position in a market.

What this article is pointing out is a classic innovator's dilemma, in which the product manager role is unable to live up to the necessity to innovate and follow these great ideas of great PMs.

Overall a great article because it calls out the 10 dysfunctions of product management as told in books like "Build what matters". Especially this thought:

> Anyone with even a speckle of greatness eventually leaves. They either get pushed out by the mediocre dictator, or they leave on their own terms, as the environment has become intolerable to them.

The irony from my experience is that there are great people who want to do great things. They want a great PM and they want to follow a compelling vision. The modern day challenge is what companies are starting to identify... Vogons. "not actually evil, but bad-tempered, bureaucratic, officious and callous". Also known as middle management.

Over 100 trillion microbes in our bodies and 1% of those are thought to be bad. Seems like a fair fight (I.e. 1.0:1.8)

There is an importance of knowing your worth and weight if you are loyal and subject to exploitation.

Just because you can get shit done does not mean it is okay for managers to dump work on you where others are failing to pull their weight. You will burn out and you will be resentful of those exploiting you.

Also with regards to monetary value, ask for the raises regularly and prove that your work leads to said results. You should be getting the maximum rewards and having your salary adjusted based on the competitive market rate. Apply regularly to remind your employer who you want to remain "loyal" to that they can lose you if they aren't keeping up monetarily.

There are very few people in the world who look out for your wellbeing if you are "loyal". They will not help make space for when you need to take time off, they will not advocate for your promotions/career growth if you're in a crucial role, they will not see the disparity of how much value you bring versus how much you're rewarded.

You have to advocate for all this yourself. Be loyal to yourself first.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540911/ Suggests both pros and cons depending on if the facility is at capacity already or not.