Interesting they didn't mention the studies of why low-dose gained popularity as some of the initial study amounts were quite high! (up to 1g):

https://www.ctsu.ox.ac.uk/research/british-doctors-study

https://biolincc.nhlbi.nih.gov/studies/cdp/

https://biolincc.nhlbi.nih.gov/studies/amis/

https://www.nejm.org/doi/full/10.1056/nejm198907203210301