1,157 karma · joined February 11, 2021
This is why open source and open data is important
Causes dopamine efflux out of the uptake transporter*
We don't have a distinction for when other animals do things, there's no logical reason to separate humans
Doses are incredibly portant when discussing the mechanisms of drugs and comparing them because a compound may interact with new and different proteins when the concentration gets high enough. Recreational doses for methamphetamine and cocaine are all over the place partially due to the fact that you can develop tolerance and increase your dose. This doesn't really happen with MDMA as much, and while you can take repeated doses they will rapidly stop working if taken within a small enough time frame. Methamphetamine and cocaine do not have the same tolerance build up
While cocaine is a triple reuptake inhibitor and does interact with serotonin, I don't think its comparable to MDMA
The studies I'm aware of were done on mice, which have a significantly different metabolism than humans. Not to mention there has been no mention of neurotoxicity from the current MAPS studies.
What makes them equal pharmacologically?
Its not, its actually one of the best far sources and its a seed oil
Don't make ridiculous blanket statements, its just plain wrong
Keep in mind that this is not necessarily experimentally valid due to the small sample size of n = 1
This means tracking all nutrition including micro nutrients (such as magnesium), tracking sleep, tracking exercise with breaks load and warmup, tracking sleep and heart rate along with spo2
Literally track everything you can think of. After you have baseline data, start by making one small change at a time (while tracking it of course) and see what happens
You literally just studied and worked ahead. That is not cheating...