joshuamcginnis

It was the first statin approved by the FDA. Thanks for pointing that out.

One of the first FDA drugs made from fungi was lovastatin, a statin sourced from Aspergillus terreus, a close relative to the Aspergillus in the subject article.

He's definitely full stack.

Odd. I always do `conda activate base && conda update conda` on Mac and never have any issues.

What's wrong with rvm?

I really love miniconda for managing python versions and deps myself.

It needs to be done at the embryonic stage before cell division so that as the cells replicate, they inherit the desired changes. The technology isn't quite there yet to transfect every single cell in an adult body with a virus containing the desired genetic modifications. Also, I can only imagine the downstream of effects of the body transcribing this modified dna in a fully-developed human. Have you ever seen the movie The Fly?

I believe this suggests that we could CRISPR an embryo to knock-out the offending Alu element in the TBXT gene and the child will develop a tail.

I recently stumbled upon a freelance gig from someone looking to hire someone to submit applications for software engineering positions on their behalf. They were willing to pay a few dollars per application and would provide all of the content for the submitter.

I'm involved in two different government-funded bioremediation projects that are exploring the use of fungi to remediate superfund sites. The challenge is not in fungi's ability to accumulate PFAS or heavy metals; it's in doing it cost-effectively over the current methods. As OP pointed out, in most cases, pollution is simply buried in a location that the EPA has designated safe for disposal.

This is the first time I've seen the use of spent brewers yeast as the biomass for bioaccumulation. However, it falls short of addressing the economic feasibility of extracting the accumulated metals, an essential aspect for practical implementation.

The ability of fungi to absorb metals is well-documented, but the real-world application of fungi for purposes such as bioaccumulation and bioremediation is predominantly hindered by the economics, including high labor costs, expensive inputs, and slow processing times.

Hopefully in the future we can dump a bunch of used brewers yeast into a giant gold tailings pond and leech gold and other precious metals for cheap, but we're not there yet.

I like this. One of the issues I'm hearing from the SWE hiring community is that a lot developer applicants are too generic. Here, the developer managed to combine a passion and niche (gaming) with a skill (javascript development) and has taken the time to build demonstrable projects, including an engaging website and YouTube channel. There's a lot here that can be emulated for other developers looking to differentiate themselves from the mass of generalists.

Where does it say use let everywhere? I see only one section that explains let vs. let! and it makes no preference for the former: https://www.betterspecs.org/#let

On a related note, I highly recommend Better Specs for spec-writing best practices:

https://www.betterspecs.org/

What app or service login did you crack with your clients in these meetings?

I'd like to see more brilliant minds from tech explore other industries, especially the trades. It is incredibly difficult to find competent and trustworthy tradespeople at a reasonable price today. There is so much that a former SWE could bring to the table that doesn't necessarily mean being the tradesperson themselves (though that would be great). The trades desperately need manpower on all fronts.

Lichens found in extreme environments on Earth (rocks in Antarctica) were sent to space and exposed to the elements. Some survived.

The fungi used were lichenous and affixed to mars-like and moon-like substrata, not unlike the stone-like environments they were originally sourced from in Antarctica.

We'd have to define "dumber" because adult literacy and numeracy rates have largely increased globally since the 1990's.

https://ourworldindata.org/literacy

I'd imagine the cost of storing apps from users utilizing free allowances increases exponentially. If charging a reasonable fee for storage is what it takes for the business to operate sustainably, I'm more than fine with it. Here's more technical background on the decision:

https://community.fly.io/t/we-are-going-to-start-collecting-...

My anecdotal impression is the pace at rolling out changes and features seems to have also increased.

Minimum six months severance pay + healthcare + cash bonus. That is incredibly generous all things considered.

If you're ever in the Los Angeles area, I recommend a visit to the Museum of Jurassic Technology: https://mjt.org/

Hey, cool! Would love to stay connected. Feel free to hit me up on LinkedIn (but no worries if not!): https://www.linkedin.com/in/joshuamcginnis/

I just shared a nice chat with a gentleman from Detroit working on some interesting LLM stuff. If you see this, great to meet you!

According to the U.S. Bureau Of Labor Statistics, there are approximately 1.8M software devs in the US. Layoffs.fyi shows about 8K layoffs this year, which is only about .4% of the total market. Crude calculation but telling.

https://www.bls.gov/ooh/computer-and-information-technology/...

> The economy as a whole is doing great according to pretty much every single measure.

What about inflation? Office vacancies (and the looming debt crisis)? The national debt and interest? Stagnant wages? Housing affordability? Low birth rate? Just to name a few.

How does one reconcile the numerous tech layoffs[0] with the fact that "US Jobless Claims Plunge to 187,000, Lowest Since September 2022"[1]? Is non-tech sector hiring making up for the tech losses?

A chief US Economist is quoted:

I would not take this result literally, but, at a minimum, it seems clear that layoffs remain quite low and are not trending higher in a meaningful way, he wrote in a note.

From what I'm hearing, that sentiment is not in alignment with tech right now.

[0] https://layoffs.fyi/

[1] https://www.msn.com/en-us/money/markets/us-jobless-claims-pl...

This used to be the case. So many people have gaps attributed to "consulting" that the feedback from recruiters is now something like, "well since you've been independent so long, how do we know you can work well with others?" eyeroll