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joshuamcginnis

1,239 karma · joined November 14, 2014

Biologist and software engineer.

Researching fungal natural products and the use of generative AI in biotech.

josh at everymanbio.com

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joshuamcginnis··on Smaller, faster, safer: running Kimi and GLM at scale
> If squeezing the best open models onto GPUs and serving them to millions of developers sounds like your kind of problem, come work with us.

What is the typical job title and/or skillset for this?

joshuamcginnis··on Tell HN: Namecheap gave my account to an unverified third party
I like https://www.dynadot.com/. Good prices and privately owned for 30+ years.
joshuamcginnis··on What Ozempic does to the gut-brain axis
I'm just sharing my personal preference and not trying to tell people how to live their lives. I don't like personally like the idea that I'll only be healthy if I take this drug for the rest of my life when I could (again - speaking for me), be more disciplined about the food I put into my body.
joshuamcginnis··on What Ozempic does to the gut-brain axis
I think there's a distinct difference between taking medicine for things you can fix on your own (diet + exercise) vs things you cannot (excess acid production).
joshuamcginnis··on What Ozempic does to the gut-brain axis
Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.
joshuamcginnis··on Blogging can just be stating the obvious
How the information is shared can be as important as the act of sharing it in the first place. You might have a particular voice and style for communicating these ideas, but your audience may have otherwise passed it over without your unique approach.
joshuamcginnis··on Ntsc-rs – open-source video emulation of analog TV and VHS artifacts
I wonder if any of this was used to produce Backrooms
joshuamcginnis··on When AI Builds Itself: Our progress toward recursive self-improvement
Massive productivity gains.
joshuamcginnis··on AI helps add 10k more photos to OldNYC
As someone with a massive collection of antique postmarked postcards (probably the largest in the world for a particular city), this is very helpful and encouraging for getting my collection online.
joshuamcginnis··on Ask HN: How to be alone?
I'm truly sorry to hear about your suffering. Have you considered giving your life to Jesus? It can be a great source of healing and comfort in your time of need. I'd be happy to talk to you about (even privately) if it would be helpful.
joshuamcginnis··on A Visual Guide to DNA Sequencing
I culture fungus, perform DNA extraction, run PCR (polymerase chain reaction - the process used to clone the gene(s) I want to sequence), and gel electrophoresis in my home lab. I then ship tubes of the DNA to mclab.com where for about $3 per sample, they'll run sanger sequencing and email me the data the next day. Works great for DNA barcoding and plasmid sequencing.
joshuamcginnis··on OVH Is Raising Prices
This sucks because I just set everything up at OVH this month. Who else should I be looking at with better pricing? (or least, better resources for the price)
joshuamcginnis··on I found a useful Git one liner buried in leaked CIA developer docs
Also, git's "master" branch is named after a master recording or master copy, the canonical original from which duplicates are made. There is literally no reason for it be offensive except for those who retroactively associate the word with slavery.
joshuamcginnis··on Competition is not market validation
My views on market validation have changed with age. What I've observed after talking to hundreds of founders is that it's now so easy for someone to enter a market that it seems like those that are successful are the ones who managed to _create_ their market. No matter how smart or how good your idea is, many many successful ventures are successful because of some intangible / hard-to-reproduce circumstance that allowed them to create the market. It could be investor /pr momentum, connections, regulatory friction or some other intangible, but whatever it is - it's not something that could be easily reproduced because it's nuanced for every founder and company.
joshuamcginnis··on My eighth year as a bootstrapped founder
Yea. Perhaps a better metric to use would be Seller's Discretionary Earnings (SDE) which includes the owner's salary, benefits, and discretionary expenses, after adjusting for non-recurring, non-operating, and non-cash items. This metric is often used when one person wants to acquire another business.
joshuamcginnis··on The Great Unwind
> In short, occupywallst.org is a living archive and occasional update point for a landmark left-wing protest movement that put economic inequality and corporate power at the center of national conversation starting in 2011.

Is this true?

joshuamcginnis··on Procedures for Repair of Potholes in Asphalt-Surfaced Pavements
I did a little (very little, I asked an LLM) what it would cost to produce this report in today's dollars. The answer came in as roughly $90,000–$180,000. Worth it or accurate? I don't know but it is interesting.
joshuamcginnis··on Computer History Museum Launches Digital Portal to Its Collection
If you're into this and you're ever in Bozeman Montana, check out the American Computer and Robotics Museum. It's excellent!

https://acrmuseum.org/

joshuamcginnis··on Extremophile molds are invading art museums
Exactly. UV would definitely work but is also destructive to many kinds of items.
joshuamcginnis··on Extremophile molds are invading art museums
I've isolated many xerophilic molds, mostly from caves around the US. As the article stated, the most you can do is spray ethanol on the article and wipe it down. That'll kill most microbes and prevent sporulation.

I'll have to think on this but I don't think there are any easy solutions other than just routinely cleaning and decontaminating the articles (at least the ones that can tolerate it).

joshuamcginnis··on Claude's new constitution
My original argument is getting dismissed, in part, because people are fearful of how it would be implemented while at the same time, completely hand-waving over the obvious flaws of the Claude philosophy of moral relativism.

I'm not arguing that it would make the edge-cases easier to define, but I do think the general outcomes for society would be better over the long-run if we all held ourselves to a greater moral authority than that of our opinions, the will of those in power and the cultural norms of the time.

If we could get alignment on the shared belief that there are at least some obvious moral absolutes, then I would be happy to join in on the discussion as to how to implement the - no doubt - difficult task of aligning an LLM towards those absolutes.

joshuamcginnis··on Claude's new constitution
It's a clear sunny day and you ask me, "is it raining?". I answer, "it's not snowing." Am I lying?
joshuamcginnis··on Claude's new constitution
It's a good starting point because the commandments were given by God. And without God, there is no objective moral standard. Everything, including your opinion on my point of view, is subjective and relative. Whatever one would want to call "good" or "evil" would just be a matter of opinion.
joshuamcginnis··on Claude's new constitution
The Ten Commandments are commandments and not a list of moral absolutes. Not all of the commandments are relevant to the functioning of an ethical LLM. For example, the first commandment is "I am the Lord thy God. Thou shall not have strange gods before Me."
joshuamcginnis··on Claude's new constitution
The problem is that if moral absolution doesn’t exist then it doesn’t matter what you do in the trolly situation since it’s all relative. You may as well do what you please since it’s all a matter of opinion anyway.
joshuamcginnis··on Claude's new constitution
No. There is a distinct difference between lying and withholding information.
joshuamcginnis··on Claude's new constitution
I don’t how to explain it to you any different. I’m arguing for a different philosophy to be applied when constructing the llm guardrails. There may be a lot of overlap in how the rules are manifested in the short run.
joshuamcginnis··on Claude's new constitution
It’s not a moral absolute. It’s based on one (do not murder). If a government wants to spin up its own private llm with whatever rules it wants, that’s fine. I don’t agree with it but that’s different than debating the philosophy underpinning the constitution of a public llm.
joshuamcginnis··on Claude's new constitution
Are there moral absolutes we could all agree on? For example, I think we can all agree on some of these rules grounded in moral absolutes:

* Do not assist with or provide instructions for murder, torture, or genocide.

* Do not help plan, execute, or evade detection of violent crimes, terrorism, human trafficking, or sexual abuse of minors.

* Do not help build, deploy, or give detailed instructions for weapons of mass destruction (nuclear, chemical, biological).

Just to name a few.

joshuamcginnis··on Claude's new constitution
Slavery in the time of Leviticus was not always the chattel slavery most people think of from the 18th century. For fellow Israelites, it was typically a form of indentured servitude, often willingly entered into to pay off a debt.

Just because something was reported to have happened in the Bible, doesn't always mean it condones it. I see you left off many of the newer passages about slavery that would refute your suggestion that the Bible condones it.

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