funnym0nk3y

However I think it is important for children to get sick. Humans need pathogens to train their immune system.

Could be over sooner than she thought. No, AI is not going anywhere soon. But NVDAs monopoly on accelerator cards is much more fragile.

How long does it take for the information to get published? If the information is published after the transaction is done and the corresponding insider info got public there is no advantage here.

In addition healthier people could be wealthier.

However the causality is not clear. Inflammatory agents cause depression. And most depressed people have higher pro-inflammatory markers. It could also be the case that the inflammation is a result of something completely different.

However the article states that that is a different damage.

Depression presents with many symptoms, some of the are mutually exclusive. Take for example psychomotor changes. It could be retarded or agitated. Some people have anxiety, some don't. Some are irritable, some sleep very much and some sleep very little. There have been the classifications of melancholic and atypical depression, but they aren't used very often as many patients have features of both.

Now consider the poor response to available medication (IIRC 30% remit and 60% respond, which leaves roughly 40% with a potential deadly disease without medication). Some symptoms of depression occur in other mental illnesses, like the similarity between bipolar and unipolar depression. Maybe the disease we currently call depression is acutally a cluster of diseases. That's the reason to look for biomarkers that separate those different diseases and the develop treatments specifically for one disease. Similar to the development of brexanolone for postpartum depression.

Placebo in depression is strong because placebo effect involves the opioid system, particularly the mu receptor. That receptor is known to have antidepressant effects when stimulated.

If you mean ECT by electroshocks, then yes, it's reliable but poorly tolerated with possible memory loss and cognitive impairment. It's still unknown how it works. TMS is very different from tDCS as the power in the brain is very different.

However here are mental health struggles listed. Poor work life balance or loneliness are not mental health issues comparable to those NIMH includes.

You could build it with a slight angle. Or gradually steeper like a high speed race track.

But that's not true. The senses are not off as you wake up when light increases, when there is a loud sound or when there is a stron smell. In addition there are numerous examples that the sound of the alarm clock gets integrated into the dream, maybe as a telephone sound for example.

It seems like his version is missing lots of parts in comparison to the original one. They probably aren't there being useless. The engineer who designed the original backplane must have thought something. So, what's missing?

And when to stop working on yourself and start dating? Which metric to fulfill? Unfortunately there are people that are predisposed to certain difficult personality traits. Personality heritability is about 50%. So working on it is a limited affair. Nobody is perfect, and dating is about finding someone who is comfortable with your imperfections and your with theirs. Nobody owes me anything more than basic human rights and dignity. And what I expect I try to give to others.

I always wondered (and still do) what people feel when they dress up to date. I've always thought of it as hiding my true personality. Showing someone different. Playing a role. Does everyone feel like that?

What does this mean in the context of depression? Sleep deprivation is a method to treat depression for a short time until medication kicks in. In addition in the former melancholic depression there is a recognized pattern of mood improvement over the course of the day.

You said it already, it's self reported data.

There are at least two possible alternative explanations for your experience:

- Similar people group together. You said you have depression, so you tend to affiliate with similar people.

- Biased perception. You tend to notice the things your mind is revolving around. Like people with a pregnancy scare seeing children everywhere.

In addition surveys showed that most people have a positive hedonic tone and report being happy. I won't argue against the rising prevalence of mental illnesses in developed countries. However it seems that those numbers are just more diagnosed cases that did go unnoticed. In general. There are contributing societal factors like inequality, loneliness, etc. that make the US have higher rates than europe for example.

Somehow I think of epigenetic processes. That COVID had an interaction with the way genes for mitochondria are transcribed. I also heard somewhere that mitochondrial dysfunction is related to psychiatric diseases, IIRC bipolar disorder or depression. Although that mechanism seems different as antidepressants and mood stabilizers don't make a dent long COVID.

GABA = depression is a crude oversimplification. Consider benzodiazepins, which cause an increase in GABA signalling as they are allosteric modulators. They cause a significant relieve in someone who is depressed.

That's maybe the essence of a growth mindset. I want to play. Winning is secondary.

I don't think there is a "good by default" dimension. Maybe a "learning easier" dimension. I'd argue that in such advanced spheres comparison becomes secondary. First an foremost it's about the activity. Like friends competing in a game of cards. It's about having fun with friends. Winning is for having a purpose to play.

I'm not sure about that. Being in a state of constant fear of failure doesn't enable one to do great stuff.

Now, does this work with adults too?

Psychiatric diseases did exist thousands of years ago. OCD is a disease I know of. Yes, medication does not cure the underlying illness. And yes, it allows a patient to function in society. Which is, considering everything, a good thing. Being so depressed that you are bed ridden and your body hurts, or so agitated that you could not sleep for days puts a temporary chemical lobotomy in relation.

It's still highly controversial.

Effects don't last that long (long enough though to get someone out of debilitating depression or mania and time for proper treatment) and need repeated courses to sustain.

There are still issues with memory, where one looses maybe a few days, but also could loose years.

That's not entirely clear. Psychopharmacology changes the brain long term.

SSRI are way better tolerated than irreversible MAOIs.

It's very possible that the combination of antidepressants and CBT is superior. Antidepressants enable you to relearn faster und CBT teaches you what to learn.

I saw a hypothesis (which is older than I thought) about CFS being related to the vagus nerve. At the time I read it, it made sense to me. Basically, an residual infection close to the vagus nerve signals the brain that the body is fighting a serious infection.

https://pubmed.ncbi.nlm.nih.gov/23790471/

Having this side by side with the original scan and a highlight where the text is found in the original would be an amazing product. I hated scrolling through scans of old literature in university...

Honest question: Is the italian society really that perfectionistic or was your perception back then not spot on?