funnym0nk3y

Sorry, but that is nonsense. Compared to opus haiku doesn't cut it most of the time.

There is not really much funding in Europe. At least not for start-ups. There is simply not enough compute in Europe.

Given proper oversight yes.

Otherwise companies can absolutely get a monopoly and cement it. Buy up competition, pressure adversaries, hog resources and so on.

If past predicts the future people will drop it once it is in Musks hands. And as a token reseller that revenue is not that impressive.

But revenue is not really the informative quantity. If you sell gold you will have a huge revenue, but very little profit. I can be a trillion dollar company too if we exchange dollar bills for face value.

Because since then Russia has threatened nuclear war a dozen times. Russias threats are worth almost nothing.

Yes and no, there is no easy binary answer here.

At altitude most AA is radar based, thus a lower RCS will help directly in not being seen. So you can get closer to the enemy you still can see because of the higher RCS. For BVR fights this is essential.

Those machines shouldn't be low level though. IR missles don't care about RCS. It is not their natural territory either.

Third that Cessna is not hidden either. From above (i.e. an AWACS) it can be seen very good. From the ground it can hide low and slow. But so can dedicated planes too, which is practised regularly.

Aren't they all on AWS?

Lithium is far from the drug with the highest amount of side effects among psych meds. Take the first generation antipsychotics for example. They are nasty.

As a matter of fact, lithium patients aren't much worse off when it comes to kidney function. Especially with modern levels of around 0.6 to 0.8 mmols.

Lithium has many modes of action, ion channels like you said, but also GSK3 function, BDNF changes and many more. It even changes the DNA methylation.

Lithium cures Bipolar the same way all the other psych meds do. They don't. They just manage symptoms. Like insulin does, or antihistamines, etc. A propper cure is rare in medicine.

There are so many misconceptions about lithium wrt to the human body.

I don't know why so many people differentiate between lithium orotate and the lithium carbonate in psychiatry. Although they differ in absorption the active component is the lithium ion in both cases. Dosage is done according to lithium content, there are tables for converting from orotate to carbonate and back.

Then the effects of lithium orotate and carbonate can't be that different. And thus, above a particular dose blood monitoring is mandatory.

There are benefits of low dose lithium for sure. And the dosages in psychiatry have been on a steady decline. With lower doses come less side effects. It is definitly not the hammer of psychiatry that turns people into zombies or messes. It feels quite natural.

In addition the reduction of Alzheimers cases is not unique to lithium. Many meds cause Alzheimers rates in mentally ill people to decline to general population levels.

Well, I thought of adding high volatile insecticides to the bags.

I'm surprised that they use such a tame method for eradication. I expected the use of huge loads of insecticides.

In general mice need larger doses of most medication candidates. AFAIK this is because they have a faster metabolism compared to humans. In addition I don't think there is a overdose risk with psychedelics.

I don't see the advantage over a simple text file accessible by MCP. Could you elaborate?

Although I like the idea in principal, I don't see the real use case here.

Most of the examples can easily be replaced by pen and paper which is faster than building a app. More complex use cases require more complex solutions which I'm not sure this provides.

One use case could have been an application to study functions in time and frequency space. But does it provide an fft?

Which is a myth. Renewables can in fact supply most requirements if they are coupled with battery storage. Then the price would be cheaper than nuclear still.

Also, natural gas is much much better than coal for the environment. And more responsive too so dark and calm times can be handled as well.

So, why are we not doing it? Lobbyism, lock in, politics, nimby.

Because cost is an incentive to do or not to do things. You know, not everyone can have everything.

Water usage in humid regions is not a problem (and not nearly as efficient for cooling). Is a problem when consumption gets so high that ground water levels change or fossile ground water is used.

Yeah, but the nuclear waste would be a problem. The cost would be a problem too.

I don't get why some people won't get that nuclear is not the solution to the energy problem. Nuclear is one of the most expensive energy sources, and that's without the cost of long term storage of burnt fuel. Without the cost of health issues in mining areas.

The call for energy consumption reduction is not "for cultish reasons", it's because of climate change that's already screwing us.

Indirectly yes. Instead of releasing additional carbon first into chemical products and then after they are waste into the atmosphere, the carbon is pulled out of the atmosphere first.

That is reasonable though. Comparing the product of a small company with little resources with giants like Google and OpenAI in a field where most advances are due to more and more expensive models is nonsense.

Thought so too. I don't know how it could be different though. They are competing against behemoths like OpenAI or Google, but have only 200 people. Even Anthropic has over 1000 people. DeepSeek has less than 200 people so the comparison seems fair.

There are multiple theories that focus on different ethiologies of depression. Besides brain networks, early life adversities, sleep disturbances and the now obsolete monoamine hypothesis I read about the inflamation hypothesis. On a higher level that ties into all the other theories quite well and I don't oppose it. But there has been research into TNF-a, IL-6, IL-4, COX-2, and so on. We know there is inflammation, but we don't know where it starts and why. SSRIs are antiinflammatory in general, but why? Is this a downstream effect? Where is the original target we want to hit?

All those possible targets need to be verified by actual treatments. Treating the increased diabetes type 2 risk in depressed people is still advantagous but won't help the depression much. It's like changing tires on a broken car. Pushing is easier, but won't run by itself.

This is common with SSRIs/SNRIs.

For me it is not at the same intensity at all times, but it can reach levels where I forget the name of my roommate or the name of my friends partner. However, I still know that I know their names. It feels like there is an error in the communication between parts of my brain. Like it's comming any time now. But it doesn't.

Although everything seems to be researched thoroughly there are many mistakes. Mistakes that are pretty basic (like Venlafaxine having it's origin in an amphetamin instead of tramadol) and lead me to the assumption of sloppy work. In addition study results are stated as facts whereas reproducibility is very poor in psychiatry.

In addition microdosing escitalopram at like 2,5mg/d seems like it is mostly placebo. When introducing a drug there are dose response studies done, that determined that ESC needs 10mg for most people to be effective against depression. Same with 2,5% of the starter selegiline dose.

I think the texts of this author need to be viewed with much caution.

Unfortunately I don't have specific studies at hand right now. However depression was classified as melancholic and atypical. Melancholic depression is marked by pronounced diurnal mood variation among other things. There was one study that measured negative and positive affect in MDD and healthy controls. It was shown that the mood variation is related to positive affect in MDD.

That pattern inspired a short term treatment for MDD where sleep is limited or completely omitted. That has a very pronounced antidepressant effect in many and can even trigger mania.

Also, I have seen lots of cases among friends and family that show that behaviour.

EDIT: To clarify: This is true in a subset of patients. It is not a necessary condition.

It has long been known that eveningness correlates with various mental health conditions. In addition sleep is used as a marker for mental state.

Usually depression improves in the evening, sometimes very specifically at dawn. So does anxiety and OCD for some. To the point where there are little to no symptoms. In the morning however, the illness is back in full force.

There are numerous studies on the involvement of the circadian clock in depression and bipolar disorder. Many agents treating those conditions alter the circadian clock.

On the other hand there is significant improvement in many people with depression at night. In the morning however life looks dark again. Some argue that this is an indicator for a different subtype of depression.

I wonder how that ties into the hyperconnectivity induced by various psychoactive substances like psilocybin.

All the research about GABA and glutamate seems too low level to me and not specific enough for treatment targets. Somewhat like using body weight to determine that disease.