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friedegg

198 karma · joined April 4, 2018

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friedegg··on Investigators say they've finally identified the Zodiac Killer
"Asked how a teenage boy could've committed a crime more than two decades ago, a police spokesman explained 'He's very clever.'"
friedegg··on Dad makes teddies with health conditions to help children with medical disorders
I had several eye surgeries related to my congenital cataracts as a kid, including one where I had to wear an eye patch bandage for a few weeks. I remember being given a Mickey Mouse doll with a circular band-aid over the same eye, similar to my own. I peeled it off right away. Maybe I was a cynical kid.
friedegg··on Walmart unveils low-price analog insulin amid rising diabetes drug costs
Because there's a push for insulin affordability, and they look really really really terrible when someone brings up a chart of the rise in the price of insulin over the past few decades.

https://divabetic.org/2017/06/08/transparent-pricing-works-h...

They fear a Congressional inquiry and federal price caps. Normally, you'd expect a new medicine entering the market to get cheaper as the production ramps up, yet it's gone the opposite direction, even after the patent has expired.

friedegg··on Walmart unveils low-price analog insulin amid rising diabetes drug costs
But the patent on this, insulin aspart (humalog is insulin lispro, the competitor), is now expired, so the patent isn't a factor in the cost. The fact it costs 10x more than it did when it was introduced to the market in the mid-90's is just absolutely crazy.
friedegg··on 1991: Trade Wars 2002
I still remember one particular game in the mid-90s where there was basically a corporation of several "evil" players vs. me and another "good" player. We eventually played to a stalemate where neither side was going to get a clear victory.
friedegg··on “Is curing patients a sustainable business model?” asks Goldman Sachs (2018)
Most type 1 diabetics take 2 types of insulin (except for people on pumps). One is your bolus insulin, which is faster acting, usually used before meals or to bring down high blood sugar more quickly. The other is your basal insulin, which is slower acting, typically taken once or twice a day, which provides insulin for your body's background metabolic processes. People on pumps typically just use the bolus type insulin, since the pump can continuously supply small doses every few minutes, which allows for finer tuning more quickly.

Until about 25 years ago, the normal bolus insulin was Regular insulin, which is just like what your body makes. However, injecting it into fat makes it work more slowly, so you'd take it a half hour before eating, and it would peak a couple hours later. Currently bolus insulins are a genetically tweaked version that allows the body to absorb it more quickly, within a few minutes, with a peak in an hour or so. In the human body, there's an even faster phase 1 insulin response, but to get it as a type 1, you'd need to inject insulin into a vein. It can be done, but it is considered extremely dangerous.

Basal insulins are generally regular insulin mixed with something to delay action or modified to do the same. Older ones like NPH needed to be taken roughly every 12 hours, but had a relatively high peak, which sometimes meant you needed to time a snack to deal with that. Newer ones offer a much flatter action curve, and can often be taken just once a day.

friedegg··on “Is curing patients a sustainable business model?” asks Goldman Sachs (2018)
As a type 1 diabetic, I feel this. It sure seems like there's a lot more money to be made from me selling insulin, testing supplies, pumps, etc, that I'll need to use for life (29 years and counting) than in finding a cure, which perhaps they can sell me once, or maybe yearly. I know there are people working hard to find a cure, but I also know that they struggle with getting funding.
friedegg··on Apple Music Announces Spatial Audio and Lossless Audio
I ripped all of my CDs to FLAC, then I was able to convert those to Ogg Vorbis at the time for my portable player. Later I converted the FLACs to mp3s, and used Apple's iTunes Match, so I have access to them on various devices for $25/year.
friedegg··on Amazon launches Amazon Pharmacy for prescription medicine delivery
I took a look, and didn't see any huge price breaks.
friedegg··on Gas selling for under $1 per gallon in 13 US states
What we need is an oil barrel subscription service. For just $20/mo, they'll deliver a barrel of oil to your house or business. For $25/mo, they'll throw in a bucket of coal. Makes a great holiday gift.
friedegg··on Mysterious heart damage, not just lung troubles, befalling Covid-19 patients
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surf...

Among the speculation is that a blood transfusion may be a viable treatment.

friedegg··on Sucralose with carbohydrates may blunt the body’s ability to metabolize sugar
As a type 1 diabetic, I can confirm that vast quantities of aspartame do not cause my blood sugar to rise.
friedegg··on How much longer will we trust Google’s search results?
They used quotes to take the place of + which used to be a prefix you could add for words that were required. We lost + to Google+.
friedegg··on AirPods Pro owners complain of worse noise cancellation after firmware updates
The first time I put them on, I was in a room with a fan, and I thought it'd lost power because I didn't hear it. Took me a second to realize, nope, it was the noise cancellation.
friedegg··on CollegeHumor shuts down
For the content creator, Google's Takeout service will give you an archive of your videos, so if you know you're shutting down, you can get them before then.
friedegg··on Finding the real first post on Instagram
Tesla tried to warn them that exact science is not always an exact science.
friedegg··on CGA in 1024 Colors – A New Mode: The Illustrated Guide (2015)
It's just really really blurry. I can see colors fine, and if I zoom OSX all the way on my external screen, I can read text. If I only had that vision, I'd probably be able to move around in the world, ie walk to the store, but I'd have a hard time doing many things I take for granted.
friedegg··on CGA in 1024 Colors – A New Mode: The Illustrated Guide (2015)
I was born with cataracts in both eyes. One was removed when I was a toddler (including the lens), and the other (with better vision) was left alone until I was a teenager at which point I got an artificial lens implant. I can't see ultraviolet out of my eye without a lens as far as I can tell (or maybe I can and just never noticed).
friedegg··on [dead]
I had the same thought. This would be the sort of weird game mechanic the could introduce in a Portal 3.
friedegg··on Whatever happened to the noble art of the manly weep?
I found out my mom died while I was at work, age 37, after a short illness (I was going to see her the next week), and although I generally kept it together that day, at one point, while talking to one of my staff on the phone, I just completely lost it. I think I cried in a way I hadn't ever before (maybe I've had a fortunate life). What was oddest to me was that I couldn't control it at all, but I was still able to think and even had a conversation with them over Slack while this was happening.
friedegg··on Ask HN: We are shutting down our startup, I get our code. What now?
It was the plot of one of the seasons of Orange is the New Black.
friedegg··on Over the past 35 years, views on privacy and Caller ID have flipped
This reminds me of the age of Call Back Verifiers for BBS identity checking.
friedegg··on Verizon/Yahoo Blocking Attempts to Archive Yahoo Groups – Deletion: Dec. 14
Some were gated over to Usenet, and you can see traces in Google Groups, but I'm not aware of any mass archive of them.
friedegg··on Risk of Acute MI After the Death of a Significant Person in One's Life (2012)
My dad has this happen shortly after Christmas the year my mom died. They'd been together nearly 50 years, and I don't think he ever really considered that she might die first. After Christmas, after we kids had all gone home, he woke up one morning knowing something wasn't right. He took some aspirin, and drove himself to the hospital. He'd had a massive heart attack, and was in that mid-60's age range where they often kill you. His doctor asked him if he believed in the afterlife, and told him if he did, he must've had someone looking out for him, because he was very lucky to survive. I think a few other things may have contributed, like the fact he was very athletic most of his life, to the point his heart was more efficient than most, and that he helped take care of one of his grandkids regularly, which gave him a reason to want to continue on.
friedegg··on Routine glucose monitoring may be unnecessary for people with Type 2 diabetes
As a type 1 diabetic, I can tell you beef does not spike blood glucose and resulting insulin response just as much as rice as does. Protein usually takes about half the dosage for the same amount of grams (ie 10g of carbs / 5g of protein), and it does it more slowly. For many type 1 diabetics on non low-carb diets, protein is eaten in small enough amounts with large enough amounts of carbs that you usually don't factor it into your dosage.
friedegg··on The Messy Consequences of the Golden State Killer Case
We already have rewards for help solving some crimes, this just makes it more of a market. Participants could opt to have their rewards donated to charity. If I knew anything about DNA, I'd probably be very tempted to work on this.
friedegg··on The Messy Consequences of the Golden State Killer Case
I wonder how long until someone creates a DNA site where you can upload your DNA, and then get a "reward" if yours is used to locate a suspect, with closeness of relation being worth more. The rewards could be paid for by the money they charge the law enforcement agencies to use the database. If the rewards were high enough, you'd probably get a lot of people signing up for the chance to make money off their relatives. Of course, you'd need some way to ensure people are only uploading their own DNA, but that's probably do-able if you handle the DNA samples directly.
friedegg··on Face transplant recipient’s donor face now failing
Type 1 diabetes is a good example of this, where the body detects its own insulin producing cells as threats and eliminates them. Lots of the research in type 1 treatments isn't just about producing insulin, but figuring out how to prevent the body from destroying it again without all of the risks of immunosupressant drugs.
friedegg··on Launch HN: Coursedog (YC W19) – Resource Planning Software for Higher Ed
Yeah, I work at an EMS using university. We started using it about a decade ago because the alternative was Ellucian's R25, which didn't really compete well on features, and my previous boss had use EMS at Harvard. Overall, I think EMS has worked pretty well for us, but even now, we still deal with the politics of automated scheduling vs. faculty desires. These tools can work very well, if people will let them.
friedegg··on Launch HN: Coursedog (YC W19) – Resource Planning Software for Higher Ed
If you haven't looked at it, another big player in campus scheduling/optimization is EMS. They operate from the event/room reservation side of things, with academic optimization as an add-on.
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