1,337 karma · joined December 4, 2019
https://thehill.com/policy/technology/3928219-musk-was-denie...
Prusa also makes the open source XL if you want an CoreXY model, or you could go with a Voron which is also open source.
By that logic sugar should be a controlled substance and we should all be gonadectimized. Gonadectimized animals almost always live longer.
> And contraceptives play with hormones that are central to what makes women women.
Weirdly estrogen in utero is central to what makes male mice male mice, and adult men adult men (20–55 pg/mL estradiol in adult men or about 1/10th the level of adult women). Estradiol plays many important roles in the body of all human adults.
> These hormones are not just limited to regulating when eggs are released from ovaries, they take part in a lot of other processes. It is absolutely not surprising then that there will be other effects of long term hormonal supplementation.
> I think the best course of action would be to work on other, non-hormonal contraceptive alternatives.
Maybe, maybe not, since chronic use of any medication will result in chronic side effects and physical interventions such as copper IUDs are also associated with a host of serious side effects. The best course of action would be to develop interventions that are safe in animal models, give them to humans for a while, and monitor the outcomes, which is what is going on here.
I'm surprised that the outcomes observed aren't worse, given how strongly carcinogenic estrogens are on a dose-dependent basis in animal models. Hormones are strange. Women with many children have reduced amounts of breast cancer despite being exposed to absolutely enormous levels of estrogens and progesterone during and after pregnancy.
And the pretrained vision encoder will have at some point been trained to minimize text-visual token cosine similarity on some training set, so it really depends on what exactly that training set had in it.
There are tricks to do it faster but they all involve using other vision models that themselves are trained for as long.
> One chronic (78-weeks) study in rats with dietary levels of 0, 1, 3, or 10% erythritol (equal to > 0.46, 1.4 and 5 g/kg bw/day for males and 0, 0.54, 1.7 and 5.7 g/kg bw/day for females) (Til > and van Nesserooij, 1994) and another 2-year chronic toxicity/carcinogenicity study in rats > with dietary levels of erythritol of 0, 2, 5, or 10% (equal to 0, 0.9, 22, and 4.6 g/kg bw/day for > males and 0, 1.0, 2.6, and 5.4 g/kg bw/day) (Lina et al., 1994; 1996) demonstrated that > erythritol did not affect survival and had no carcinogenic effect.
https://ec.europa.eu/food/fs/sc/scf/out175_en.pdf
From this paper:
> In a population-based prospective cohort study with repeated dietary records, ingestion of multiple artificial sweeteners (for example, aspartame, acesulfame potassium and sucralose) was associated with CVD risk.
Ok, let's look at that reference.
> Results Total artificial sweetener intake was associated with increased risk of cardiovascular diseases (1502 events, hazard ratio 1.09, 95% confidence interval 1.01 to 1.18, P=0.03); absolute incidence rate in higher consumers (above the sex specific median) and non-consumers was 346 and 314 per 100 000 person years, respectively. Artificial sweeteners were more particularly associated with cerebrovascular disease risk (777 events, 1.18, 1.06 to 1.31, P=0.002; incidence rates 195 and 150 per 100 000 person years in higher and non-consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (1.17, 1.03 to 1.33, P=0.02; incidence rates 186 and 151 per 100 000 person years in higher and non-consumers, respectively), and acesulfame potassium and sucralose were associated with increased coronary heart disease risk (730 events; acesulfame potassium: 1.40, 1.06 to 1.84, P=0.02; incidence rates 167 and 164; sucralose: 1.31, 1.00 to 1.71, P=0.05; incidence rates 271 and 161).
This study shows the same thing with _all_ artificial sweeteners, and has way more people (n=103,388) than the present Nature study (n=1,157). And we know that erythritol is often used by type 2 diabetics due to its low effect on insulin levels. That population is predisposed to cardiac events to begin with.
When adjusting the US/EU cohorts for cardiovascular risk factors, the observed effect with erythritol are smaller and closer to this study of other artificial sweeteners.
> Consistent with the results observed within the discovery cohort (adjusted HR = 2.95 (1.70–5.12) P < 0.001; Fig. 1 and Supplementary Table 4), the association between erythritol levels (fourth quartile versus first quartile) and incident MACE risk remained significant in both US and European validation cohorts following adjustments for cardiovascular risk factors (adjusted HR (95% CI) = 1.80 (1.18–2.77) and 2.21 (1.20–4.07), P = 0.007 and P = 0.010, respectively
I'm not convinced of the validity of this study. They ignored the rat chronic toxicity data and proposed a mechanism for what they saw in a small cohort of humans, but it should be reproducible in mammals.
https://lewisbrisbois.com/newsroom/legal-alerts/15-month-pri...
Yet, at the same time, whenever it is brought up people love to engage in contrarian rambles about how it is simply too hard, people will lose their dongles, etc etc. Most phones support NFC communications these days, it's a tap against a phone or reader for verification and so couldn't be easier.
Within 10 years people are going to wonder how we ever lived _without_ this.
[1] https://www.healthcareitnews.com/news/fbi-disrupts-hive-rans... [2] https://therecord.media/canadas-largest-childrens-hospital-s...
I don't know if the UK is different from much else of the developed world, but here there is a tremendous amount of off-by-book transactions in the largest industries such as farming and construction. I do not think that the disappearance of cash will remove this economy, but it will have to migrate to other assets with similar qualities.
It's no surprise to me to see government gold buying on an absolute tear. [1] The powers that be are well aware of the importance of having real physical goods for the sake of trading and maintaining wealth.
[1] https://financialpost.com/commodities/mining/central-banks-b...
https://github.com/rom1504/clip-retrieval
It does not appear to actually show you how images were used to train a generative AI.
> Subscription Quantity Billing Total
> Ubuntu Pro 1 Billed Yearly $500.00
https://ubuntu.com/pro/subscribeFor anyone unfamiliar, Faithless was a huge group in the electronica scene in the 90s and early 2000s. Some well known hits include "God is a DJ", "Insomnia", and "We Come 1". If you're young and don't know them, check them out. For us older folks, lots of early morning memories of better times. :)