et2o

There are hundreds of clinical trials and it’s used today in clinical practice, most commonly in oncology but more and more in other fields. Very interesting work in polygenic risk prediction models in many kinds of chronic disease, where risk models can refine treatment strategies. It’s very real; one of the big problems so far has been reimbursement and commercialization.

The other thing you have to realize is that because of the regulatory burden, it takes a while for these tools to make it into practice. Many of the successful genetic tests today were approved 20 years ago. Look up Oncotype Dx which is used in a huge % of breast cancer surgery, for example. WGS and WES will undoubtedly be far superior but it takes a while to get these things into practice.

This was a talking point like 10 years ago which isn’t remotely true today

“nobody has made a compelling argument for WGA for personalized med” is a huge overreach. It’s done routinely now at most academic cancer centers and often is useful for guiding treatment decisions. There are several multi billion dollar companies that do this already.

Then you have to do 1000x the sequencing, which can get expensive on long read technologies :)

That said, that’s basically how a lot of NGS works in things like cancer sequencing on Illumina platforms.

Hard to imagine how they could fix this while still allowing people to climb it at all. Nets?

Because it’s an extremely long article and it’s a lot of work for me to do for no reward.

This is what I meant

This article is a masterpiece of disinformation.

I just played and got 10/10 right although a few were difficult. I don’t think they are all so similar.

I hope by 2100 that technology will exist using ML or similar to upcode digital video.

Where is ND? North Dakota?

You seem pretty dismissive of the article, which does present significant evidence of corporate malfeasance.

What regulator did you call?

When would it be harmful?

Agree. He is an Apple guy. He delights when Apple does cool stuff. Sometimes he takes Apple’s side on debatable subjects. But he has no issue calling Apple out when he thinks they are doing wrong. It’s unfair to call him a shill.

But they decreased the batter size on the iPhone 12 due to power efficiency gains, so battery life is approximately the same unfortunately.

It is really only charge my AirPods Pro every week or so. I much prefer having a bulkier case with battery I can forget about to a smaller case but more frequent need for charging.

It’s actually revolutionary for how I use a computing product. If i had to charge them everyday I assume they’d be dead 1/2 the time because it’s annoying to have yet another thing to plug in.

I wonder what is going on at Intel. A resurgent AMD has more or less surpassed them in COU offerings already, and now so has Apple. They have fallen so far. Can it just be institutional complacency? I don’t get it.

Wonder if Apple would buy TSMC

Haha indeed

Not at all. That is why the N on these trials is so huge. 5/15000 vs. 90/15000 is going to be statistically significant anyway you slice it. It’s a 45-fold difference. You can approximate it yourself with a t test.

This is horribly wrong. Josiah... what are you doing?!

There's nothing inherently wrong with brutalism.or modernism, lazy comment imo.

Designed to destroy nuclear production facilities. Not terrorism.

Still doesn’t seem like very long!

Alright, but on the range from nothing to perfect, we are... Far more than 2x the dark ages. More like 1000x.

We have advanced incredibly far in both treatment of CAD and ulcers. And in CAD, still making tremendous improvements within the last ten years. You don’t really know what you’re talking about at all, citing a TV show.

Laughable confirmation bias.

Give me a break

I think a nasal swab would be better than a throat swab if you aren’t willing to do a full nasopharyngeal swab.