211 karma · joined May 17, 2013
https://www.standard.co.uk/news/uk/commuters-ordered-to-repa...
Once you've seen it you'll be baffled as to why it isn't a global solution. No need for the employee or others to wait while you count your coins or bag up, and no need for anyone to wait behind you while you wait for the self-service checkout to weigh each item individually, fail to scan etc.
https://www.forbes.com/sites/forbes-personal-shopper/2021/09...
https://timharford.com/2021/03/cautionary-tales-the-dunning-...
In terms of this strain, the actual rate of mutation is higher (5.6E-4 nucleotide changes/site/year vs 5.3E-4) [https://virological.org/t/preliminary-genomic-characterisati...]
The short answer is that 'The extent to which SARS-CoV-2 may evolve to escape immunity induced by infection or vaccination is not currently known'. However analysis has been carried out to work out how far from the receptor-binding site the mutations are, and how 'antibody-accessible' these are, with a few such as . No conclusions are drawn from this analysis.
Earlier on in the report (towards the end of page 1), this statement is given `One of these (the N501Y mutation) occurs in the region of the Spike protein, the receptor binding domain (RBD), that the virus uses to bind to the human ACE2 receptor. Changes in this region of the Spike protein can result in the virus changing its ACE2 binding specificity and alter antibody recognition`.
Saying all this, vaccines are designed to create a range of antibody responses, in order to stop this very fear of a single mutation rendering a whole vaccine useless. [https://www.nature.com/articles/d41586-020-02544-6] I also recall reading somewhere that adapting the vaccine to account for a mutation (much like is done yearly with the flue vaccine) is relatively easy, though I haven't managed to find that article again yet.
> Several aspects of this cluster are noteworthy for epidemiological and biological reasons and we report preliminary findings below. In summary: The B.1.1.7 lineage accounts for an increasing proportion of cases in parts of England. The number of B.1.1.7 cases, and the number of regions reporting B.1.1.7 infections, are growing. B.1.1.7 has an unusually large number of genetic changes, particularly in the spike protein. Three of these mutations have potential biological effects that have been described previously to varying extents:
> - Mutation N501Y is one of six key contact residues within the receptor-binding domain (RBD) and has been identified as increasing binding affinity to human and murine ACE2.
> - The spike deletion 69-70del has been described in the context of evasion to the human immune response but has also occurred a number of times in association with other RBD changes.
> - Mutation P681H is immediately adjacent to the furin cleavage site, a known location of biological significance.
> The rapid growth of this lineage indicates the need for enhanced genomic and epidemiological surveillance worldwide and laboratory investigations of antigenicity and infectivity.
https://www.cogconsortium.uk/wp-content/uploads/2020/12/Repo...
https://virological.org/t/preliminary-genomic-characterisati...
After accepting it the contractor realised some of their values were wrong so in addition to attempting to find hundreds of thousands of pounds of saving from the council, they were also trying to save hundreds of thousands due to their own misestimates.
Part of this led them to select aluminium cladding over the originally specified zinc cladding which was much less flammable but much more expensive.
Re rebranding I think the industry would be aware enough. Despite the tests having been frauded previously, they would need to be redone under new company names at great expense, fraudulently or not. The more likely course I suspect is companies rebranding existing products and claiming new chemical formulas. (As was already done by Celotex: https://www.bdonline.co.uk/insulation-used-on-grenfell-refur...)
https://www.independent.co.uk/news/uk/politics/grenfell-towe...
For those interested in the engineering side of the scandal, phase 2 is amazing listening. The amount of detail the enquiry goes into is incredible. The number of failings across the construction industry with this project from architecture to fire consultants to insulation providers is shocking, but despite this you can also see why those failings occured at the time. The enquirers are knowledgeable and ask extremely probing questions, you can almost hear witnesses squirm.
Phase 1 is worth listening to part of, it's all about what happened on the night, the fire service response and failings, call center communication, broken lifts, inadequate equipment and more. However, it is very heavy and depressing listening, and quite repetitive (Phase 1 the podcast was done each day of the enquiry, phase 2 is done weekly).
I believe it's a way for them to better predict how many students they'll have next year, otherwise it can fluctuate pretty wildly based on exam day results.
https://www.organdonation.nhs.uk/uk-laws/organ-donation-law-...
IMO this gives a much better inherent understanding of equations, rather than just plugging in some numbers into a calculator and reading what comes out.
From phase 1, roughly 670MW of onshore wind and about 75MW of solar were supported. [2]
[1] - https://www.ashurst.com/en/news-and-insights/legal-updates/u...
[2] - https://www.gov.uk/government/publications/contracts-for-dif...
The windscreen wiper is very likely to be outsourced to a 3rd party company, and they can reduce costs by having a repeatable design. In terms of a blade going on a straight line, it’s much easier to rotate a wiper blade from a motor than translate that into a linear movement.
It’s worth nothing that other systems exist (https://www.a1-windscreens.co.uk/news/windscreen-wiper-movem...), but much less common.
There are plants out there where the electric vehicle model is produced on the same body shop, paint, and final assembly lines. The same steps are taken just with different parts/different dimensions.
The remainers believe it is a coup that the PM has suspended parliament seemingly in an effort to bring the country closer to a no-deal Brexit.
The leavers believe it is a coup that there is a bill with a very real chance of passing that would make leaving without a deal illegal, therefore leading closer to not leaving the EU at all.
Streets -£167m
Buses: -£722m
Rail: -£49m
Underground: £823m
Elizabeth Line: -£267m
Other: £9m
Professional Services: -£560m
Property: £69m
Media: £145m