HNHacker News
TopNewBestAskShowJobs

dmerrick

906 karma · joined July 16, 2012

[ my public key: https://keybase.io/dmerrick; my proof: https://keybase.io/dmerrick/sigs/IERAlCnLpxTmcDRxGNfYDn2Hf8o4KuZ2uQC0nyW0YdE ]
submissionscomments
dmerrick··on Ask HN: Who wants to be hired? (May 2026)

  Location: USA
  Remote: Yes
  Willing to relocate: No
  Technologies: AWS, GCP, Kubernetes (EKS/GKE), Terraform, Tanka/Jsonnet, Python, Go, Docker, Argo Workflows, Packer, Prometheus/Grafana, GitHub Actions, GitLab CI
  Résumé/CV: https://github.com/dmerrick/resume
  Email: dana.merrick@gmail.com
Infrastructure/platform engineer, 20 years in. Usually the first infra hire — comfortable inheriting whatever exists and turning it into something production-grade.

Most recently built Ginkgo Bioworks' ML model serving platform and multi-tenant GKE infrastructure from scratch (joined via the Reverie Labs acquisition). Before that, was sole infra engineer at Reverie — built their entire AWS platform from the first commit, ran EKS clusters, and supported GPU workloads for computational drug discovery.

Looking for early-stage teams solving hard problems in interesting domains. I value a culture of trust, ownership, and room to build.

dmerrick··on Tinyio: A tiny (~200 line) event loop for Python
> The reason is that await does not offer a suspension point to an event loop (it just calls `__await__` and maybe that offers a suspension point), so if we wanted to use that syntax then we'd need to replace `yield coro` with something like await `tinyio.Task(coro)`. The traditional syntax is not worth the extra class.
dmerrick··on Ask HN: Who is hiring? (May 2023)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Front-End and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we're rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We're looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we'd love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Who is hiring? (April 2023)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Front-End and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we're rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We're looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we'd love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Who is hiring? (March 2023)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Front-End and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we're rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We're looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we'd love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Who is hiring? (February 2023)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Front-End and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we're rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We're looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we'd love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Who is hiring? (December 2022)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Backend and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we're rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We're looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we'd love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Who is hiring? (November 2022)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Backend and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we’re rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We’re looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we’d love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Who is hiring? (September 2022)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Backend and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we’re rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We’re looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we’d love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to Ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Why aren't smart people happier?
Beautifully put
dmerrick··on Ask HN: Who is hiring? (August 2022)
Reverie Labs (YC W18) | Cambridge/Boston, MA | Backend and Full-Stack Roles | Onsite (Temporarily Remote) | https://www.reverielabs.com

At Reverie Labs, we’re rethinking drug discovery by building a biotech company that looks and feels like a tech company. We are actively working on several cancer therapeutics programs and building an internal platform to accelerate discovery. We’re looking for engineers across the tech stack, including data scientists, front-end engineers, and full-stack devs to expand the computational systems that generate the next era of life-saving treatments for millions of patients. If you think you might enjoy any of these types of projects, we’d love to hear from you! * Architecting a Django REST-driven internal application development ecosystem that supports multiple drug development programs.

* Building performant software for billion-scale molecular analyses alongside machine learning engineers.

* Designing and implementing front-end interfaces that enable our in-house chemistry team to interface with software.

* Using Pandas/R/Plotly/Dash or any other of your favorite analysis tools to extract meaningful insights from datasets.

* Combining a set of 25+ in-house experimental assays and 50+ external data streams into a universally accessible data platform.

* Using a modern cloud-first development stack, giving you access to effectively infinite computing power.

* Owning the full development cycle of a product from ideation to implementation to deployment (of course in collaboration with a team!)

We were in the W18 batch of YC and are now based in the biotech hub in Cambridge, MA. We offer competitive salary and above-market equity. Benefits include full medical, dental, and vision coverage, flexible vacation policy, and gym membership. If you have any questions or want to apply, please reach out to ankit at ankit@reverielabs.com, or apply at our website here: https://reverielabs.com/careers.

dmerrick··on Ask HN: Does anyone use a Raspberry Pi as your main computer?
How is this different from any other installer that asks for admin access? At least the wget method gives you an opportunity to look at the install script, which most software installers dont provide
dmerrick··on HN comment April 9, 2012: Bookmark this comment. See you in 2022
He probably bookmarked the comment
dmerrick··on Microsoft to Acquire Activision Blizzard
Diablo 2 Resurrected turned out awesome

CoD was never Blizzard

WoW (vanilla) was so good it had a second successful launch 10 years later

Starcraft 2 remains immensely popular

dmerrick··on _why's Estate
Few developers in my career have stuck with me the way _why did. I hope he is doing well, wherever he is.
dmerrick··on Interactive IPA Chart
Super useful! I would have loved this in undergrad when I was taking linguistics courses
dmerrick··on Ask HN: What was the biggest contributor to your happiness in the past year?
I don't get opportunities to share this very often... my sideproject is a 24/7 Twitch channel[1] of driving footage with a companion chatbot. If you like slow-tv you might enjoy it.

[1] https://www.twitch.tv/ADanaLife_

dmerrick··on Functorio
That's not quite as satisfying as text-based files managed via proper version control
dmerrick··on My ISP Is Killing My Idle SSH Sessions
By default `<prefix> t` shows a clock in the current pane, really handsome looking and it scales nicely as the pane changes shape.
dmerrick··on My ISP Is Killing My Idle SSH Sessions
I just want to say thank you, this was a very concise explanation of a very complex concept.

I've been working with NATs for years and your comment helped me "click" and understand them at a different level.

dmerrick··on Running Docker on Apple Silicon M1 (Follow-Up)
he means Digital Ocean
dmerrick··on OBS Studio 26.0
This has indeed been my experience. It seems to be one of those uncommon situations where a physical server is more desirable than a cloud server.
dmerrick··on OBS Studio 26.0
Does anyone have suggestions for running OBS in the cloud?

I have a project that is designed to run 24/7 and it would be really nice if I could use a cloud server instead of a computer on my home network.

I have it all set up... OBS in Docker with k8s templates. Just need to find an affordable online option.

dmerrick··on Ask HN: What are good life skills for people to learn?
I always think of this poem by Ralph Waldo Emerson:

    To laugh often and much; 
    to win the respect of the intelligent people 
    and the affection of children; 
    to earn the appreciation of honest critics 
    and endure the betrayal of false friends; 
    to appreciate beauty; 
    to find the best in others;  
    to leave the world a bit better 
    whether by a healthy child, a garden patch,
    or a redeemed social condition; 
    to know that one life has breathed easier  
    because you lived here. 
    This is to have succeeded.
dmerrick··on Neuralink Progress Update [video]
I enjoyed this joke from the stream:

> If you bombard earth with photons long enough, it will emit a Tesla

dmerrick··on New Stuff
What excellent news!
dmerrick··on An LSD Trip “Off-Switch” May Be Coming Soon
I think this is pretty normal in biology. Like how someone might have to drink 2L of water to feelbetter after a few shots of alcohol
dmerrick··on FFmpeg 4.3
The problem with calling ffmpeg multiple times in a script is you often waste compute time.

If you can manage to cobble together a single command (as illegible as that may be), you might be able to do what you're looking to do in far less time

dmerrick··on OBS (macOS) Virtual Camera
It does not look like it does: http://www.gphoto.org/proj/libgphoto2/support.php
dmerrick··on OBS (macOS) Virtual Camera
I'd love it if you gave it a try! I've already spent enough hours re-compiling ffmpeg to get nvenc support :)
Page 1 of 4Next →