An LSD Trip “Off-Switch” May Be Coming Soon

But I think the primary reason they would want to develop this would be to encourage LSD to be used as a therapy drug. A lot of people would be more comfortable experimenting in a controlled/legal setting if they new they had an off switch in case anything went wrong.

For LSD, anything to get out of the rest of a 14 hour trip and come down would be an option that the market would easily gravitate toward.

You can't reasonably OD from LSD but you can have bad trips. Some of them can be so overwhelming that they will cause lasting effect not unlike PTSD. If you can stop a trip dead in its tracks, that's one less risk. By having ways to counteract its various potential negative effects, you can improve the safety profile of the drug, and therefore make it more acceptable.

But if a fish oil medicine had those issues, I would be shocked, because the consequences for the guilty party would be much bigger, a huge circus of lawsuits and people losing their licenses. That's how I imagine it anyway.

Spoiler alert

> And I used to think that the alternative medicine people were overestimating how evil Big Pharma was. But now I know that’s not right.

> Now I know they’re underestimating it.

(though I understand a bit of the issues behind the BRCA gene testing thing and I'm not sure it continues to be banned or merely the results need to be more generic and not just "you have X% of having cancer")

They absolutely have dependency potential, but you have to be regularly taking them for that to be an issue, a fact which the doctor who was merrily prescribing me them failed to mention. Kicking them was much easier for me from an addictive perspective than cigarettes, but with dramatically worse side effects.

They’re also going to make a certain percentage of the population feel incredible (or just allow them to relax/sleep when they can’t usually), so they’re also very more-ish.

In short: taking them once a quarter is unlikely to be an issue unless you already have poor impulse control and easy access to them, in which case: just don’t start.

Strong indicas in particular, Gorilla Glue for example.

That all said, I have used a few types infrequently for helping to get to sleep and found them absolutely delightful, waking up refreshed and energised (and still somewhat relaxed) the next day.

If you aren't using it to get high (so as intended for panic attacks / aborting lsd trips) and using it very infrequently (e.g. Only for lsd trips) you'll have no problems at all.

The issues are usually when you take it daily, especially if you take enough for the recreational effects. (Although daily isn't necessarily bad if you are being very careful with a doctor).

Tl;Dr - yeah benzos have issues with tolerance/depedancy but if you are only using what you need therapeutically, especially since lsd requires you to space out trips, then you're unlikely to have issues.

You can still be awake, but you won’t be tripping any more, the sleep only comes if you actually lay down and try to go to sleep or take a large enough dose of benzos.

If there is one thing that carries a real risk of fucking up (other than ODing) it is mix consumption.

Never heard of the other experiences ITT. Alcohol is a well known off-switch in all of the beat nation sort of literature.

Then again I think we are often talking about different substances when we say LSD. You'll find someone who supposedly has this great connection and the second you take their ticket, you have the instant dread of tasting metal knowing it's not LSD.

But again, disclaimer: this is really only for folks experienced enough to know how to navigate each separate space well, and for those that have confirmed, tested, pure, high quality MDMA.

Drugs like LSD form non-covalent bonds with receptors. In a macro-world analogy, think of your hand sticking to a syrup-covered fork vs. a covalent bond being your hand stuck to a super-glue covered fork. Different drugs have different levels of "stickiness" (called affinity) for a particular receptor, and LSD has pretty high affinity for its target receptor, 5-HT2a, but it isn't permanently attached. In fact, affinity is defined by relative association vs. dissociation rates of drug-receptor complex.

On a microscopic level, each molecule of LSD is falling in and out of the receptor binding site stochastically. This leaves open the possibility of another drug binding to the same site (called competitive inhibition) when LSD isn't occupying the site. If another drug has a higher affinity, it will occupy the receptor more of the time. When you zoom out and consider the entire set of receptors and drugs, the sum of these individual stochastic events these effects follow characteristic patterns described by the law of mass action.

https://derangedphysiology.com/main/cicm-primary-exam/requir... is a pretty good description

*I'm simplifying parts of this somewhat.