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dannykwells

2,377 karma · joined August 1, 2016

Immunology + Data
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dannykwells··on College Enrollment Slid This Fall, with First-Year Populations Down 16%
There is a key subtitle: "Early tally shows sharp enrollment declines at community colleges and among men".

This isn't about the rich/elite/high end schools seeing enrollment dip. It's about seeing the poor and middle class get pushed further back. And the dip among men is particularly worrisome, since it will set them further back in education, leading to further radicalization in this group.

We should not be celebrating this as the "death of academia" - what this is, truly is, the death of the middle class.

dannykwells··on Netflix is creating a problem by cancelling TV shows too soon
Compare Netflix to HBO, and you'll instantly see the difference in how they are run. Netflix prioritizes algorithmic made content, HBO artist-driven content. Not coincidentally, HBO is much better at committing to shows long term. Even with a fraction of the content, I would take HBO over Netflix any time.
dannykwells··on When You Win a Nobel and They Can't Reach You at Home
Yeah at least for Watson!! Ew.
dannykwells··on The Nobel Prize in Chemistry 2020
Not that Michael is biased at all, either...

Anyway, I'm happy Jennifer and Emmanuelle won over others and thinks this was the right call. The discovery of the idea was the most important part here, bs showing it in human cells (which wasn't that hard afterwards).

dannykwells··on Bill introduced to promote prescribed fire intends to reduce fire risk
Healthcare worker here. Love this comment, spot on. Newsom should allocate 2B, or 20B, and create a metric of fire prevention relative to fire risk, and then reward communities with a higher value (i.e., fewer fires per unit of fire risk means more dough). That would align incentives and fix the problem (or at least, not make it worse).
dannykwells··on Research: Average Age of a Successful Founder is 45
For those interested, there appears to have been a follow up, peer reviewed study published this year, free to access:

https://www.aeaweb.org/articles?id=10.1257/aeri.20180582

dannykwells··on UC Berkeley inappropriately admitted students as favors to donors
I know I'm out of sync with the mainstream here but I think it should be fine to buy your way in to a school like UCB. The price tag should be so high that it would support say 10 or even 20 low income, highly talented students. Say 1M/year. If a family can pay, fine.

If they cant, well, they can get in line like everyone else.

This really just makes the process transparent and put a price tag on it. And now, if a professor or dean takes a lower donation for admittance, they're stealing from the school and would be put in jail, not given some wrist slap or administrative leave.

dannykwells··on On the Use of a Life
In parts of academia, there is much deeper collaboration and smaller gaps in goals, incentives, etc. Both sides publish papers everyone reads, and there is general applicability. People even, gasp, go back and forth throughout a career.

Pure math though, sucks and is total blackhole for talent. Definitely agree there.

dannykwells··on The majority of 18- to 29-year-olds in the US are now living with their parents
I live with my wife's parents. Well, really, they live with us. And I think it is glorious. Always someone around to chat with, play a game with. We get last minute childcare help and sit cooking, cleaning and upkeep. For them, well they get super cheap rent in the place they want to live and tons of grandkid time.

Multi generational housing is the the norm in so many societies. For the US to constantly bemoan it speaks mostly to our fucked up family culture and little else. I couldn't be happier living with extended family and hope to do so for a long time.

dannykwells··on Unusual Features of SARS-CoV-2 Genome Suggesting Sophisticated Lab Modification
Not to ad hom the piece, but Miles Guo, funder of this work, is a controversial Steve Bannon associate and Chinese billionaire in exile. So, you know, might have an axe to grind.

Also, for a different, and published, perspective, see this piece:

https://www.nature.com/articles/s41591-020-0820-9

dannykwells··on Blanked-out spots on China's maps helped us uncover Xinjiang's camps
Maybe time to watch The Good Place. Wont solve your issue but will give perspective.
dannykwells··on Jeffrey Epstein’s Harvard connections show how money can distort research
I am sure from a fundraising perspective, the 200K was seen as the tip of the iceberg. Harvard plays the long game. The goal is to grow donors from small contributions like this to those 1000x or more larger.
dannykwells··on The dual PhD problem of today’s startups
The author has...never heard of biotech VC? Where even the VC have PhDs and the founding team and not just 2 but 10 and also 4 MDs and capital intensive business is accepted and understood?

Seems like the author just doesnt get biotech and now that biology is becoming tech is confused where their amateur startups fit. Answer: no where.

dannykwells··on An example of how brands build fake reviews on Amazon
Ok fair point. Never mind the world is just all garbage. Take to the woods!
dannykwells··on Facebook account now required to login to Oculus devices
Everyone, I think it's time that we acknowledge that Facebook may have a slight tendency to deceptively invade users privacy and never ever keep any promise it makes. Nothing to worry about but just ya know, good to be aware of. /s
dannykwells··on An example of how brands build fake reviews on Amazon
One site that has really risen due to this, imo, is Etsy - there you know the person making the product, you can see clear examples of their work, browse their website, look at their previous work, talk with them, etc. It's the opposite of the no-name Amazon experience.

Definitely not cheap and has issues of its own, but worth checking out if, like me you thought it wasn't useful before.

dannykwells··on If founders treated their investors the same way they treated their employees
So I have a PhD, and do empathize with being "transgressive", but I'll say I think it's less about the PhD than it is about being right.

If you are bull headed and drive really hard in a new area, you better be right because you are taking responsibility and accountability for that area (whether you think you are or not). High risk, high reward - sound familiar? This is true at Google, at startups, in academia. So it's really more of a personality thing - if you're ok being obedient, you also don't need to bear the stress of accountability. But if not, well, no degree will alleviate that stress.

dannykwells··on Blackstone to Acquire Ancestry.com for $4.7B
This - everyone freaking out over this is right, but ummmm, years too late.
dannykwells··on Ask HN: Who is hiring? (August 2020)
Parker Institute for Cancer Immunotherapy | Genomic Data Scientist | Full-time | SF but Remote Possible |

https://www.parkerici.org/about/careers/

The Parker Institute for Cancer Immunotherapy (PICI) was founded by Sean Parker with a mission to accelerate the development of breakthrough immune therapies to turn cancer into a curable disease.

As a Genomics Data Scientist on the PICI informatics team, you will analyze large multi-omic data sets to identify signals associated with response and resistance to cancer immunotherapies. We work with dozens of different molecular data types, including single cell RNA/ATAC-seq, CYTOF, MIBI and other HD Imaging technologies and many more, and you will too. The Genomic Data Scientist will lead large data-driven research projects, write scientific manuscripts and give conference presentations, and broadly contribute to the intellectual community at PICI.

Expertise in any particular data type is not required, but experience working with R/Bioconductor to analyze genomic/proteomic data to answer biological questions is.

Please apply online or send CV to Danny (me): dwells@parkerici.org

dannykwells··on Goodhart's Law and how systems are shaped by the metrics you chase
While many here would hate it, Goodharts law is a powerful argument for things being obtus, vague and abstract. The less measurable something is, the less it can be easily hacked.

Also, interestingly, what will stand in the way of AGI - no definable loss function for these vague cases and scenarios.

dannykwells··on The World Doesn’t Need a New Gigantic Particle Collider
Couldn't agree more. Obsession with fundamental physics as "the only way forward as a species" is absurd. Do any of our discoveries in CRISPR or check point inhibitors rely on the knowledge of the Higgs Boson or the fundamental theory? No.

Stop the obsession with quixotic physics quests. Spend the same (or more!) resources on apied science focused on climate change, pandemics, longevity, clean energy, etc. Far more rewards in that direction.

dannykwells··on Laura Deming, founder of the Longevity Fund, on being homeschooled
Yes exactly. Anyone rich can be a scientist with the right PR. This us the postmodern dystopia we live in. (Alternatively, always has been like that, in some sense.)
dannykwells··on Laura Deming, founder of the Longevity Fund, on being homeschooled
"Laura Deming, founder of the Longevity Fund, on being an heiress with nearly infinite resources to pursue her dreams".

I think the homeschooling is likely second to being rich in terms of her world view and success.

dannykwells··on MIT Ends Elsevier Negotiations
Woohoo! First UC now Elsevier! The arc of the moral universe is long, but ever so often, it does indeed bend towards justice.

RIP A.S.

dannykwells··on Coronavirus: Hard-hit Brazil removes data amid rising death toll
This might work in the short term, but excess mortality will ultimately come out and tell the truth, unless Bolsanaro wants to claim those that died are still living (don't put it past him).
dannykwells··on The world might run out of people (2019)
Population decline is very well documented. The global trends hide countries like Germany, South Korea, and Japan where the numbers have sunk as low as 1.3 births / female, far below replacement.

The world might have more people by 2100 but many countries, including US, Europe and others will be shrinking, unless they take aggressive action on immigration reform.

My personal belief is this is ultimately how humans will go extinct. Not with a bang (apocalyptic global warming, war, famine, etc) but a whimper (gradual fade out into black over the next 1000 years).

dannykwells··on Chan Zuckerberg Initiative scientists: FB’s practices ‘antithetical’ to mission
Have any returned the money yet?

Until then, well, its just more words.

dannykwells··on Why I Use Suckless Tools
I found this section ironic, since the whole point is the lack of features:

" As dwm is configured in C, there’s also a community of people creating patches for dwm that add extra features like additional tiling methods, the ability to automatically start things with dwm, transparency for the statusbar and so much more. I use the following patches..."

Eventually, enough users will want a particular patch, and it will be agreed to include for all users. At that time, is the product still suckless?

dannykwells··on The Trolley Problem Problem
Could this be due to the rise of pure mathematics in influencing philosophers? In pure math, counter examples play a very important role: show once counter example, disprove an entire claim.

The violinist in the article is clearly trying to be a pure math- like counter example, but to me, misses the emotional aspect of pregnancy (at the least) - a fetus is not a random person, it is you (partly), and furthermore, many would say society (and the species) depend on having babies, whereas the society and the species do not depend on violin players.

Not saying I agree with these arguments only that the real world is substantially messier than pure math, and thus, pure math thinking may stumble when applied to real world problems.

Tl;dr: humans are not rational in our beliefs and the continued attempts on all disciplines to assume we are, are well, irrational.

dannykwells··on Swiss companies must pay share of rent for employees working from home
In the US of course, we deduct our home office from our taxes, meaning that our fellow citizens, or debt, support working from home. Thos seems like a saner solution.
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