dannykwells

This a thousand times. Thank you.

Also Bingo.

Bingo.

Yes exactly!!!

Bingo. The goal is positioning a duopoly / cartel as the only “safe” and “moral” path and then that cartel sets pace and price.

Slop

Tamarind is the best! Truly a YC company that provides true, bona fide value to biologists like us. (Hi Sherry!)

This is what I come here for.

A plot line literally out of a Final Destination movie (the newest one). MRI machines are scary!

Can someone explain to me - assuming they have enough data - why not train different models explicitly for each group / subgroup you want to model? You even could then just take the top N% of each group by score, effectively guaranteeing equal treatment for each group. Why would this not work?

This is honestly a fantastic outcome.

Regeneron is among the most science and data focused biopharma and has a long, long history in genetics. They know how critical privacy is and will ensure the data are used to advance human health.

Potentially an even better home for the data than in the company, since now will not have pressure of quarterly reports.

Absolutely amazing study.

This.

Time to find a long term partner and have / adopt / take care of kids.

No joke. I’ve seen it work wonders for providing meaning to many, including multiple rich-beyond-belief founders.

Note that this drug is not new - it is fully approved for ALK+ NSCLC and has been since 2015.

It's not clear why these data are just coming out now or what is different from the original trials run in this setting.

https://en.wikipedia.org/wiki/Lorlatinib

Durva is starting to show some benefit here.

https://www.cancernetwork.com/view/durvalumab-significantly-...

Founders can make a "competitive" salary, if they have existing experience for the actual job of being a founder (i.e., previous executive leadership experience).

For many, being a founder is not just "taking a risk on an unproven idea" it's also a career change from being a solo IC or technical leader to being an executive, with very, very different requirements for success, so the risk here is compounded.

100%

Did you see Greg Brockmann also quit? Who do you think has contributed more to OpenAI code base??

Best response on this yet.

Agree with this. Internal power structure between academic types and tech-forward commercialization types.

It might be this is good at the end of the day. OpenAI is just not structured to win.

Completely agree. Sam is on the phone with Satya as we speak.

Alternative is Sam goes in house to MS who already have all the weights of GPT-4 and build again, but constrained by any existing charter.

Said in the George Senior voice: And thats why you don’t use a non-profit to do world critical work: politics will always beat true value at a non-profit.

This should be higher voted. Seems like an internal power struggle between the more academic types and the commercial minded sides of OpenAI.

I bet Sam goes and founds a company to take on OpenAI…and wins.

Completely false straw man post.

1. Most of the data cited stops around 2010, ignoring the huge progress that checkpoint inhibitors and cell therapies have made in many cancers.

2. Mixed up issues of treatment progress and treatment access. Treatment progress is a fact, but can be missed if patients don’t have access.

Access in the US is essentially a political issue - states with Medicaid expansion, for example, have better overall access than those that don’t. Also, in general, changing Medical practice is slow, even once a therapy is approved.

The narrative that we have only poor treatment options that don’t advance misses the true progress that has been made, and let’s those responsible, ie insurance companies and politicians off the hook.

“Without me, the University of Córdoba is going to drop 300 places [in the Shanghai ranking]. They have shot themselves in the foot,” said Luque, who attributed his suspension to “pure envy.”

Seems like they really lost a real gem with this one /s

All this bluster about replacing technical jobs like legal counsel ignores that you are fundamentally paying for accountability.

“The AI told me it was ok” only works if, when it’s not, there is recourse.

We can barely hold Google et Al accountable for horrible user policies…why would anyone think OpenAI will accept any responsibility for any recommendations made by a GPT?

Precisely. This was not about SVB, or any morality tale on VC etc. Any other action would create systemic contagion that could spread far and wide.

Yes.

Elizabeth is expecting and will give birth in early 2023. This is a mercy for the judge to allow her to not give birth in prison.