My point was that there are so many more healthy cells vs infected cells except on rare instances that even it kills healthy cells too they are far larger in number. Just like what happens during radiation treatments or any number of other treatments.
Still it would likely be a staged treatment that wouldn't kill the entirety of infected cells in a single dosage. The benefit is that you could see if there were adverse reacts before continuing.
Nah you would be given a dosage large enough just to kill the invading virus. It could hurt the person, but killing them is unlikely. Actually wrote a paper on a something similar I came up with back in undergrad using HIV.
My undergrad took this to the extreme. Our lowest level math class was Calc 1 and to get into the class you had to either take Calc AB in High School or show up to school a couple months early and take it before Freshman year started. I knew people that would fail out of our engineering program and go to another and get a 4.0.
Me personally, I had to unlearn all the bad crap my Physics teacher in High School taught me. It took an entire semester to get back on track but was well worth the hard work.
You can see how much harder Engineering and the Sciences are, from my own experience I thought getting my MBA was a breeze compared to studying engineering. Nearly everyone else struggled and worked their asses off, they had zero preparation for all the math and logic problem you had to work through. The solution is to force EVERY major to take a few REAL math classes and REAL science course so people have a solid foundation.
Big fan of using Central and South American developers. You don't have the time zone issues, their English is usually fantastic, and the cultural differences are minimally (when compared to places such as India). Used them all the time when I had my own firm and didn't have time or resources for in-house development. Also a big fan of the Kiwi's if you have something you can hand off with a fully defined spec.
Damn I really should have stuck with the education iOS market. Was in the top ten for quite a while when the app store first launched and was making good money, just could only ever manage to keep an app up in the rankings for a few months. Focused on the physical product side instead of the mobile app side... Wow that was a mistake...
This is bogus. Hate all this overpopulation nonsense. Every developed country in the world other than the US has a negative replacement rate (births - deaths). The developing world is rapidly slowly as well. If I remember right the world only has another 50 years or so of positive growth. Not only that but the demographic skew in the developing world in male-female will likely cause it to slow even faster. The slowing growth and shrinking populations will be the huge problem of this century because our social structure in its current form can't survive a shrinking population.
Move a sample video to the landing page or put a big "view first video for free" button on the page. You want a persons eyes to be drawn to 3 things: logo/call to action, packages, and the sample.
Think there is room for one more player in the market. Think Amazon, Facebook, or a partnership between the two could really make a splash. Eventually when the HTML5 frameworks become more developed and there's more fluidity between the app stores, who knows how that will change the landscape. But I don't think Microsoft can move fast enough anymore to compete in the ever quickening marketplace.
It has to do with dilution and something called liquidity preference. If an investor puts in $5 million and has a 2x liquidity preference they get out $10 million before anyone else. That happens to every investor on down, whatever is left is then split among the common stock/options holders. There was likely nothing left or what was left was less than your option strike price.
Integrating web and specifically mobile technologies with the real world and physical products. Creating a seamless interface, some companies are just starting to explore this in the medical and entertainment areas. The next set of billion dollar companies should come from this area. It'll take awhile though since there are only a handful of people with the skill sets to launch and guide the companies.
Another reason and a big reason seems to be past success, you need people with capital to invest. Once an area gets a couple large companies to cash out not only do those people tend to invest or start companies in similar industries but people around them see their success and want in on the action. If Groupon has a successful IPO and enough employees cash out Chicago could very well become the next large hub. This is the reason why you need a physical hub, but I think AngelList might be removing that hurdle.
On the same note, the investors, lawyers, and employees in startup hubs have 'standard terms' where as in other parts of the country the terms get extremely complicated with things such as tranches. They understand what it takes to succeed since they've usually done it before and are there to guide the company.
There's nothing you can do about it other than leveling the playing field by eliminating special loop holes and laws designed to protect the established elite. You shouldn't do more, technology is the root cause. An individual skilled in fully optimizing their productivity can produce far more than someone without those skills, so wealth will naturally accumulate with those individuals. It's amazing when you think about it, today I can completely design a web or mobile application, a consumer electronic device, or any number of things right from my computer, and I do on a daily basis. How much more productive am I than someone utilizing only manpower? That's the income gap disparity.
It's the same thing on Wall Street, do they abuse the system, yes, but computers allow individuals to far more access to a variety of assets around the world within milliseconds. Those with the knowledge, say like algorithmic traders can use there knowledge and the ability to leverage their positions to make a fortune.
They always look at the brackets, not the movement between them, and there's huge movement between brackets.
With the death of Flash, for front-end web development, likely right around the corner this is a great strategic move by Adobe to stay relevant.
Maybe they'll create an XCode like tool for HTML5 using PhoneGap as the glue. With the acquisition of TypeKit it really looks like that's the direction they are heading in. Would be an interesting and useful product.
Nope, no job. Interviewing now, pretty much an interview a day right now. Already got two offers.
Nope didn't lose anything on the sublet, other than the fact I had to stay in a hotel for a few days.
Yep that would be a problem. I didn't have anything holding me down. I'm big against home ownership unless you plan on staying in one place for 10+ years or the market is liquid and priced under the rental rate.
Just moved here a week ago. Housing is the biggest pain in the butt, had a Craigslist sublet fall through on me twice. Now looking for a sublet in October.... It's a pain.
I've found there are a ton of networking events (106 miles, Hackers and Founders, etc) on meetup. Also if you find an interesting company just email the CEO. In the Mission district of SF right now and I really like it. The tech scene here is really hot, if you've got skills just email the company you're interested in, they'll talk to you.
This is exactly what I did. I treat the MBA as just another tool. Started a business sadly it failed after a couple years, but I just moved out to SF last week and loving it. As an engineer with an MBA that can code well, does stats, and took a handful of law classes it's a seller's market.
If you decide to put this into production and need help/advice on how to bring the costs down, manufacturing, or logistics let me know. Really you just need to standardize the hardware, find one manufacturing that uses nearly all those parts and you'll be good to go.
That's nearly very plant, factory, and warehouse in the world. There's nothing unique about these conditions. When I was younger and worked in my family's plant I'd get to work before 5am to beat the heat. Sometimes I couldn't and the heat was brutal, but you learn to deal with it (set up fans, take more water breaks, change your clothes).
My specialty is creating consumer electronics and web/mobile applications that seamlessly integrate. Have quite a lot of experience with this. Check out my blog, it's in my profile, wrote a popular article here on HN (it's also on my blog) on how to and the tools to use when designing, prototyping, and manufacturing consumer electronics. If you have further questions feel free to email me, done it enough I can usually figure out what you'll need to do pretty fast.
Exactly, the "poor" in the United States have it better than the middle class in Europe. This is from an article today,
"...the typical household considered "poor" by census officials has a car and air conditioning. For entertainment, the household has cable or satellite TV, two color televisions, a DVD player and a VCR. If children (especially boys) are in the home, they have a video game system such as Xbox or PlayStation. In the kitchen, the household has the ordinary conveniences: refrigerator, oven, stove, microwave.
Half the poor now have a personal computer. A third have a widescreen TV (plasma or LCD); a quarter have a digital video recorder such as TiVo."
Have a 14 year old TI-89, that I still use to this day. It's small, simple, quick, and have all the functions and symbols I use under the custom menu. Amazing their haven't been any screen and function improvements (built in programs).
Been actually getting a lot of questions about this lately, think I'll write a post on it. But here's a short summary: Example I was creating a product in women's apparel so I would go to a bar, find a group of women, and buy them a round of drinks, the women would talk for hours about the subject (as an added bonus it also helped the social life). Don't underestimate interacting with the customer and seeing how they use the product. Instead of asking, do you like this, find out why and how they come to their decision.
When I do web products, the UX, I'll create a wireframe/mockup then find people and ask the question, "How would you do X". Then see how they think through the interface. After a couple iterations I'll create a quick web app to test varying hypotheses.
Another tip, I do this when forming a pricing strategy, is to form a few cases (X price with Y features). Then see which the person picks or test one at a time and see which gets the most responses. You can do DOE or multivariate analysis and come up with a near optimal solution.
Always get a kick out of the markup on cables. USB cables in bulk are less than $0.50, HDMI cables aren't much more. Profit margins on them are ridiculous.
You have no control group so the $1038 vs $626 or unemployment numbers are meaningless. The top would natural succeed even without going to college, you can't tell how much value it actually adds.
No they wouldn't there are a lot of procedures that cost more than a 100k (any transplant, open heart, high end implants are more). Really the government and insurance companies would save a fortune if the cure cost between 100k - 200k.
Completely right. Didn't want to go into detail meant the anti-virus theory and why. I'll try to explain. You want to use HIV because of a few unique properties specifically the fact that you can split the gene material used in replication from the infection machinery. In addition it actual has most of the genes in place to do all the work you need since it's so well mapped and studied modifying the structure becomes much easier. My idea was to limit the insertion to only the original material (like a seedless watermelon) to remove the danger. And have virus upload the sequence needed to produce the antibodies or receptors required to target the foreign object. Then have the body kill it itself.
Wrong mind set, they could easily charge 100k+ for the treatment and insurance companies would still jump for joy since it's cheaper over the long run.