anotherboffin

Was a good mix of funny and frustrating here. Adding input lag would definitely have made it infuriating.

Not the OP, but I guess they meant non-Swiss as someone who might be used to a different set of tipping norms?

Any good pointers on how/where to get started?

Oof that looks brutal

He’s a cycling journalist (specialized in tech), not a shop owner.

Just to add some context: e-bike commuters in a hilly city would go through the stock organic brake pads in <500 km sometimes. Could be as little as 6 weeks. The shop I worked at (back in the day) would replace them with longer wearing third-party pads.

Good point! I’ll be more careful before quick posting.

Yeah, I suspect “Melissa” fed Lowe’s article to an LLM to get a quick article that’s sure to get views.

Oh but no worries, FSD is a “solved problem” and should be done in 18 months or so…

They didn’t offer free repairs, but they also didn’t limit it to five countries.

Not an applicant, but thanks for your app!

I enjoy using both, but you’re leaving out microphonics (especially on zippers), cable tangle and getting frayed/damaged/caught on clothing, just to name a few.

I’m on Garmin watches as well but this line of thinking is getting old. Partner has an Apple Watch and they charge it while in the shower/getting dressed and occasionally 10-15 minutes in the evening to make sure it gets through the night. Charger is in a convenient location and it’s dead easy to drop the watch on it. If you’re running ultras, then by all means stay on Garmin. But honestly for the day to day I’ve rarely seen it be an issue.

ETA: there’s plenty of valid reasons to prefer other watches (ANT+ compatibility being one of mine) but honestly the battery life thing is really not that bad for most users.

I guess creativity and technical advancements take longer than the yearly upgrade cycle required by marketing.

I had heard that in the context of absurdly high hematocrit, where they would get their heart rate up to move the (very viscous) blood around their body. No source, but doesn’t sound impossible when everyone was on EPO.

> […] it's still impossible to not have all your apps plastered on the home screen, at best in folders, is a mind boggling missing feature in iOS.

You didn’t even try looking, I just checked all the way back to iOS 14 and it was already possible. Yes, it doesn’t change your opinion, but undermines the point you’re making.

If I remember correctly, part of the goal here is to gain a bit of time while the patient gets to the ER. I’m no expert but as you seem to have alluded to, the risk profile of alteplase/tenecteplase doesn’t seem to be well suited to an autoinjector with “if in doubt, use it and call the ambulance” instructions.

Hypothetically, and just out of curiosity: if mint2 were to keep this email and it would be included as part of the evidence in a lawsuit, how would this bode for Lidl?

Pretty close. Without getting into what is “cheaper and easier”, the work you need to do to publish is a bit different from the amount of work you need to do to: identify targets, set up screening assays, screen hundreds of thousands of compounds, find/optimize a hit, set up secondary assays, optimize the lead compound, do all kinds of physchem/tox/safety studies, select an indication, test in animal models if good ones exist, try and find a suitable dose range, and put all that into a package to support a phase 1 trial. This is part what I’ve seen on the biology side of things, and it only scratches the surface of what the chemistry (small-batch synthesis and the scale-up), pharmacology, and associated people contribute.

Lots of people can synthesize and test a compound in vitro. Doing the above is another challenge because it needs to work reliably in humans.

And yes, from my understanding, universities are getting better at patenting and licensing their IP. Some even do some basic drug discovery IIRC.

Formulation is pretty important too. Do they give any detail on that?

Nice summary! From my limited knowledge in case someone’s more interested. Don’t know if it’s different in oncology.

Phase 1 is pretty big on safety: sentinel dosing, then gradually increasing doses until the established max is reached or until serious side effects show up. Generally also includes PK/PD aspects: what is the half-life, how long it’s detectable in the body, does this match the modeling? How is the drug eliminated? All this is used to refine the dosing (if need be) but also provides a lot of the information needed for the safety documentation.

I’m pretty sure you are correct. At least from the way I’ve seen it used (I took cancer biology lessons but it was more on a cellular level)

Genuinely wondering why you mention “in a vacuum”, as the signal would have to go through the atmosphere.

You are correct, though my knowledge of finance is insufficient to give you much more detail.

NTA 8776 spec-rated helmets are built to withstand more forces than “regular” bike helmets. IIRC they are required in certain EU countries when riding an S-Pedelec (45 km/h limit pedal assist e-bike)

Maybe OP is “stuck” with shitty hydraulics from a lesser-known vendor for which it’s difficult to get the parts? I’d say they look into the cost of getting the whole system replaced, my Shimano low-ish end hydraulics have worked fine for years and as you’ve mentioned, parts are easy to get.

You should be able to stay away from most repairs if you check your brake pads regularly and make sure you change them before they fully wear out.

In addition, do know that the discs and even brake fluid will need to be replaced at some point to keep things working well, hope this can avoid a bad surprise!

> Modern bicycles (except new e-bikes with chain guards and internal hub gears) require degreasing and lubing every two weeks

Yes and no. Modern 11/12 speed chains maybe, but my commuter (9-spd) gets lube every 4 months or so. Yes, I have to monitor the chain wear and change it every few years, but that’s not very complicated. It goes to the workshop less often than the car.

They’re more expensive, but you can find non-electric bikes with a belt drive and a gearbox or gear hub which are very low maintenance.

> BTW, they still charge a ~10% premium in Switzerland compared to the rest of Europe, just because.

What’s your source? I just checked for an iPhone 14 Pro (base spec) CH: 1179.- FR: 1329 € DE: 1299 €

> adopt software for large enterprise and adapt the business

It’s not my area of expertise, but isn’t that kinda what SAP is known to bring?

Edit: formatting