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alexholehouse

3,113 karma · joined August 3, 2011

My lab studies how biological function is encoded into disordered proteins using a combination of theory, simulations, informatics, and experiment.

https://holehouse.wustl.edu

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alexholehouse··on Denmark: 1,000 Megawatts Of Offshore Wind, And No Signs of Slowing Down
That is breathtakingly poor journalism/general knowledge
alexholehouse··on The underappreciated power of common courtesy
An acquaintance recently made a facebook update describing how they belittled and berated a coffee shop employee for making a (fairly bad, to be fair) mistake regarding change on a $20.

I seriously considered leaving my office and going to the coffee shop to apologize for this person's behavior, and I personally am finished with this individual in both a social and professional context. There is pretty much nothing I find more offensive than rudeness when people make a mistake.

alexholehouse··on R, the master troll of statistical languages (2012)
Language issues asside, R is being propelled by an awesome group of developers (such as Hadley Wickham, Dirk Eddelbuettel, John Myles White, Brian Ripley etc). These people are why R is as successful as it has become - both through continued work on various aspects and packages and direct interaction with users new and old. Frankly, there should be some kind of slightly awkward parade for them all.
alexholehouse··on Ask HN: I received a DMCA claim against a Tweet, advice sought
Disclaimer: I am not a lawyer. Not even once.

If I remember correctly (from reading about this, not experiencing it!), if you counter-claim they will either

> drop it

> sue you (must occur within 2 weeks of the counter claim)

I have no idea about how this would proceed, but if they do sue you you'll need all the fun that entails, which may be a whole load of work.

Frankly it does sound like complete BS, but the question is do you want to be the one to fight it, and could a good lawyer on their side make it stick? I feel like the law is still very much struggling with this whole internet thing, so if I were you I'd be apprehensive about assuming rational through would prevail.

alexholehouse··on Introduction to Machine Learning
Minor plug - if you're following the CS229A course you may find my notes useful

http://www.holehouse.org/mlclass/

alexholehouse··on Should I give up part of my online identity?
I don't see why they want it when it would presumably only confuse and provide no benefit to any party, at any point, in any way.

I actually think you'd be doing them a business favor by explaining why (from this fairly brief overview at least) it's a horrible idea.

alexholehouse··on Google Keep, a New Service for Taking Notes
Phil Libin's long term plan for Evernote[1] is precisely what this sort of application requires, and is at total odds with Google's product release/discontinue approach.

Google Notebook was "discontinued" only a few years ago - and the kinds of consumers who would be interested Keep almost certainly share a significant overlap with those who two years ago were interested/used Notebook, and therefore have literally been bitten by Google in this exact space in the last few years.

[1] http://vator.tv/news/2013-01-17-phil-libin-on-an-evernote-ip...

alexholehouse··on Be Happier: Things to Stop Doing Right Now
Impressing

No one likes you for your clothes, your car, your possessions, your title, or your accomplishments. Those are all "things." People may like your things--but that doesn't mean they like you.

Sure, superficially they might seem to, but superficial is also insubstantial, and a relationship that is not based on substance is not a real relationship.

Genuine relationships make you happier, and you'll only form genuine relationships when you stop trying to impress and start trying to just be yourself.

Impressing should be a side effect of being exceptional at something. The above paragraph describes, "caring what people think about your appearance". I'm not sure it has all that much to do with impressing.

alexholehouse··on This is What Happens When You Run Water Through a 24hz Sine Wave
I feel like there's some information theoretic approach which could be leveraged here, and maybe in similar systems - ie. just from the video we can work out

- The difference in video frame rate vs sound frequency based on the period of the wave

- Maybe the structure of the wave itself based on the waveform, although maybe not.

alexholehouse··on Announcing Kiln Harmony: the Future of DVCS
I'm really looking forward to these posts - it seems like a lot of the problems you would have faced are specific examples of more generalized data integration issues. Accordingly, the approaches used may have more general applications, which would be cool to tease out from your implementations.
alexholehouse··on Letter from Steve Wozniak to a high school student in Korea
I've said it before, and I'll say it again, Woz is the catalyst that pushed me into programming, and that is something I'm perpetually thankful for.

I should write him a note...

alexholehouse··on LaTeX Templates
I use LaTex for a lot of my note taking (for typesetting all equations certainly). When I first started using it, I remember the absolute horror of trying to get it to work with BibTex. The learning curve is relatively steep for non-programmers (I learnt it basically in parallel with learning to code) but it's certainly one of the most valuable tools I've learned and one I continually come back to for a huge range of projects. Certainly in an academic environment it continues to surprise me that everyone isn't taught LaTex in their first year of a PhD.
alexholehouse··on Ask HN: Rate my OCW math curriculum for comp sci
I think it depends a lot on what you want to do.

For any kind of machine learning or data processing, linear algebra is definitely a good thing to have. Basic calculus is good too, but I'd say may be less important if you're applying methods and approaches as opposed to developing them too. Differential equations, while providing an important set of mathematic tools which may open some doors you didn't even know existed, may not be the "highest yield" material from a programmers point of view.

In my opinion, probability and statistics is a big yes for anything data related, doubly so for algorithms. I'd also consider some graph theory, as it's amazing how many problems can be projected as networks and then approached from that perspective.

alexholehouse··on What Thomas Edison expected job candidates to know
All of those are what I would call common knowledge that an average human being should know.

I don't mean this in a rude way, but if you honestly believe an average human being will/should know all these, prepare yourself for a life of abject disappointment.

alexholehouse··on Desiderata
Reminds me a lot of Baz Luhrmann's "Sunscreen" (or rather, Baz Luhrmann's "Sunscreen" reminds me a lot of this)
alexholehouse··on In Defense of "The Big Bang Theory"
I hate the big bang theory, and for the longest time I've tried to put my finger on what it is I don't like about it. I think it comes from a mixture of two things.

The writing making the characters repeatedly try and display how smart they are (which I'm aware is integral to the show) but to me makes them totally and desperately unlikable. That, coupled with the general tension building component of most sit-coms where all too frequently characters do what is clearly a bad idea, followed by some form of "make it better" set of actions.

I know that if they [the characters] made a mistake and just repaired it in a very mundane way this would not be good television, but I find it incredibly jarring that these unlikable characters have one thing going for them, their intelligence, yet seemingly couldn't find their way out of a paper bag.

(EDIT: This reflects the relatively few episodes I've seen, but every time I see one I feel exactly the same)

(EDIT2: Perfect example from a comment below,

"When he [Sheldon] drops some furniture he is carrying to debate the point that pulling it up the stairs would reduce the required vertical force by exactly fifty percent and not about fifty percent, he is doing something weird and nerdy..."

Debating yes, absolutely, but scientific debate by itself isn't funny to the general population (Deestan would enjoy it, I might enjoy it, but Joe Bloggs on the street probably wouldn't care) so he drops it. That's not smart. If the show was consistent he'd then point out that the loss of energy from dropping it far outweighs the benefit of moving it around, or he'd break his toe.

It's this orthogonal slapstick which seems totally incongruous with Sheldon's typical behavior which annoys me.

alexholehouse··on Don’t believe everything you read
I try and debunk/explain [shady] biological science news wherever possible here. In fact, it's typically my only contribution, but one I feel is highly important.

Your perpetual (and totally correct) crusade against PhysOrg reminds me there are others doing the same, and for that I thank you.

alexholehouse··on Mega Overtakes Rapidshare, DropBox
Is traffic to Dropbox.com indicative of anything? I've been a Dropbox user for years (yo-yoing between paid and unpaid plans based on my need - the ability to do so is something I hugely appreciate) but never visit the site.

Is this not the equivalent of judging Windows usage based on visits to microsoft.com?

alexholehouse··on Stack Overflow was down
FYI: http://www.downforeveryoneorjustme.com

e.g http://www.downforeveryoneorjustme.com/stackoverflow.com

alexholehouse··on Game Over: Zynga Shuts Down PetVille And 10 Other Titles
With these kinds of games I really surprised Zynga didn't provide a more graceful wind down. As the article suggests, there must be HUGE numbers of people with real emotional attachment to their characters/pets, who almost by definition are Zynga's most loyal customers. SURELY a business decision which exclusively hurts those who are stakeholders in the games you produce is, from a long term perspective, just a horrible move for customer loyalty and reputation.

If I'd put 4 years into a pet on Petville, only to have the game basically deleted from under my nose, there is no way I'd ever become involved in anything Zynga does again.

[Disclaimer, I've never actually played any Zynga games, so this is based on second hand conversions/observations]

alexholehouse··on Requests, Python HTTP for Humans, reached v1.0
This is great new - I recently integrated requests into my current project, and it's made many things a lot easier!
alexholehouse··on I'm 85 and I Learned To Code. You Should Too.
FYI, the "Please support our crowdfunding campaign CS in HS." link from that blog post doesn't work. Just a heads up.
alexholehouse··on Hackbright Academy Turns Women Into Developers In 10 Weeks
Not necessarily a response to this article, but more generally about "learning" (complex) things such as programming languages, the impact of impressionist art, particle physics etc.

With all these things, I would argue, that you through a kind of 3rd order polynomial experience of time vs. your confidence in your own knowledge. At first you know nothing, and you're aware you know nothing. After some short amount of time you've learnt a huge amount, relative to what you did know, so you feel like you have a good grasp on the topic. But, over more time, you begin to realize how much you actually don't know (which may reflect everyone, or just reflect yourself, the latter meaning you can learn from others, the former meaning you better get your thinking cap on). Hopefully then over EVEN more time you begin to slowly increase your knowledge base, but this time from a more informed perspective.

The point is, I guess, that it's hard to assess your own knowledge of a topic at this very moment in time unless you've spent a decent amount of time getting your head around it's true complexities (where both, "a decent amount of time" and the true complexity of the topic will vary HUGELY from case to case).

alexholehouse··on CodeHS Wants To Teach Every American High Schooler How To Code
You have an exceptionally optimistic view of "everyone's" abilities.
alexholehouse··on Bay Area Rental Price Heatmap by ZIP Code
Quick mash up adding plots for population density, % renter property and % owners (this took about 2 minutes - I was just intrigued how they all compared, which seemed especially relevant given the most recent XKCD).

http://www.holehouse.org/other_content/sanfran.jpeg

Source of maps: http://maps.webfoot.com/demos/demographics/

alexholehouse··on Oracle should buy HP and rename itself HP
After the last two years, possibly (probably?) not - but surely that brand value is incredibly contextually relevant anyway. For consumer electronics, I probably wouldn't buy Oracle's tablet the Elisson-3000, but if I were building a server farm I'd be more inclined to go with Oracle over HP given the apparent management issues, the current Autonomy debacle, and their flip-flopping in the consumer PC space.

Irrespective of that, presumably an acquisition decision has more to it than , "HP is a better brand so we should buy HP" (this is not rhetorical)?

I'm not necessarily disagreeing with you, especially given your background, I'm just genuinely interested as to your reasons.

alexholehouse··on Oracle should buy HP and rename itself HP
Could you explain your logic?
alexholehouse··on UK'S shadow Internet minister says she is "particularly stupid"
This is probably my favorite comment of all time on the internet.
alexholehouse··on Mistakes when Applying Computational Intelligence & ML to Stock Market Modeling
Nice, accessible paper, but I find it galling that the images are so low quality. This paper is by no means alone in suffering from low image quality - I was reading a Nature paper earlier today where the graphics had compression artifacts.
alexholehouse··on Reimagining the Windows Command Line
Most features are incomplete

Sounds all too familiar :-).

I don't have a windowsbox available right now, but demo looks great.

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