Hacker News Reader

Knufenon Two days of oatmeal reduce cholesterol level

This is wrong, there is no proof of an anabolic window.

Are these the same studies where they grouped frozen pizza with regular beef?

Beef and chicken does not cause cancer anymore than anything else does. It is an insane take that regular food causes cancer in any level that should be worrisome. Don't cite the studies where they grouped frozen pizza in the same category as beef.

Knufenon What nicotine does to your brain

Not a doctor, but can recommend methylphenidat any day over amphetamine. It is a much less "angry" version and the slow release evens the effect.

Knufenon Creatine found to improve cognitive performance during sleep deprivation

5 mg? We get about 1 gram of creatine through a varied diet and the body synthesize the rest. I would guess it to be purely placebo for you? All lifter recommend 3-5 g of supplementation daily.

Knufenon Study finds female astronauts more efficient

That sounds very interesting, so you have a source for that? I could not find anything on Google searching for "life expectancy, gender and size".

Knufenon Denmark, Norway, Sweden, and Finland to Operate as a Joint Air Force

As a Dane this appears true on the surface but not when diving deeper. Some in Greenland might desire independence but it has neither the economy nor the willingness to adapt to actually move forward with it.

Knufenon Sperm counts worldwide are plummeting faster than we thought

All plastics are endocrine disruptors [a], though the an easy filter is softer = worse. If anything food related is in contact with plastic there will be plastic in the food. The pH and temperature of the food have a big impact on plastic leaching.

And sperm quality mostly affect fertility. The egg and the body if the woman is incredibly effective at selecting quality sperm and rejecting bad sperm. There are multiple guidance systems for sperm which selects for good quality [b].

a. https://www.niehs.nih.gov/health/topics/agents/endocrine/ind... b. https://en.wikipedia.org/wiki/Sperm_guidance

Knufenon Sperm counts worldwide are plummeting faster than we thought

No, but it does affect fertility, as well as various cancers. Breast cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286136/, cervical cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801991/ and fertility: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479690/

Knufenon Sperm counts worldwide are plummeting faster than we thought

Though it is a funny Alex Jones quote there might actually be some meat to it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122794/

Knufenon Sperm counts worldwide are plummeting faster than we thought

Generally yes. Beware of drinking bottles made from stainless steel. A lot of them are lined with plastic to avoid the metallic taste.

Knufenon Sperm counts worldwide are plummeting faster than we thought

There is an ongoing discussion on the effect of caffein on sperm quality. There are articles which describes a possible route for DNA damage to the sperm from caffein https://www.cureus.com/articles/109365-effect-of-stress-and-.... From personal (lab) experience there is a clear difference to the smell of sperm from a coffee to a non coffee drinker, so it ends up there somehow. Whether it truly has an effect is still being discussed.

Knufenon Sperm counts worldwide are plummeting faster than we thought

I did my Master Degree in Organic Chemistry where we tried to develop a male contraceptive pill. I spend a lot of time studying sperm so here is a short list of thing to avoid regarding sperm quality (not ranked):

1. Eating and drinking from plastics (This includes aluminum cans which are plastic lined) [a]

2. Heating food in ANY type of plastic [a]

3. Caffein intake [b]

4. Sugar intake [c]

5. NOT exercising regularly [d]

6. Alcohol [e]

7. Age [f]

8. Stress [g]

9. Soy products or other natural products containing phytoestrogens [h]

I edited the comment to add point 8 and 9.

Funnily enough these goes for both genders regarding fertility. If you are considering having a child, it takes approximately 7 months for sperm to fully develop so better to change lifestyle sooner rather than later.

a. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222987 b. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482951/ c. https://pubmed.ncbi.nlm.nih.gov/35606632/ d. https://rep.bioscientifica.com/view/journals/rep/153/2/157.x... e. https://pubmed.ncbi.nlm.nih.gov/28029592/ f. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253726/ g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260894/ h. https://pubmed.ncbi.nlm.nih.gov/18650557/

Knufenon Do breastfed children have higher IQs? The answer is annoyingly hard to uncover

Perhaps instead of saying "this is bad", you should expand.

Knufenon I visited a friend who is watching Breaking Bad. Now clips appear on my YouTube?

Pure guessing but your phoned showed your location and what you were watching (through your friends data), and thus recommends Breaking Bad to you now.

Knufenon Ask HN: How do experimental research companies exist financially?

I worked for a "small" 60 people biotech/oncology company which were continually in the negative, financially speaking. The company existed like this for 20 years, selling potential drug candidates for hundreds of millions (DKK). The idea behind the company was so good that investors kept it alive and it was then bought for billions (DKK) by a big American biotech company.

Knufenon Tell HN: I made $1000 with my app and now making $500/mo

Does the data model have to be changed? Can't it just be a simple "fill exercise and how many reps/kg you want" type of thing?

And understandable with your limited time!

Knufenon Tell HN: I made $1000 with my app and now making $500/mo

Super cool project man, congrats. I was unable to figure it out in the app, but is it possible to build your own routine instead of 5/3/1? I have been looking for this kinda of app and am willing to pay for it.

Knufenon Ask HN: How do you keep social life if WFH?

If you have the time, join some amateur sport or hobby center. And then put in the energy.

Knufenon EU considers banning use of up to 12,000 toxic chemicals

As other posters note some feed-forward defense mechanism requires a larger dose to elicit a response. Sometimes small doses have a cascade effect meaning A->2xB->6xC etc whereas a larger dose would activate a feed-backward mechanism between B and C.

A classic example is endocrine disruptors (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036398/), a small dose induces a hormonal response, a medium dose the body fights due to detecting it as foreign and a high dose is just regular toxic. Please note this is somewhat simplified but used as an example.

Knufenon EU considers banning use of up to 12,000 toxic chemicals

Organic/medicinal chemist here. Some toxin, endocrine disruptors and many other things have widely variable toxicity curves. Something we often see is U curves. With high toxicity in both small and high doses. The small doses can induce cascade effects (like hormones).

Knufenon Turning scrap copper into beautiful crystals

I have a master degree in chemistry and during my studies have grown quite a lot of crystals. As a lot of the other posters point out it is due to capillary effects; both formed by the new crystals and by microscopic channels and irregularities in the container.

If crystals didn't 'want' to grow we would often cool the solution down and scratch the bottom of the glass container with a metal spatula.

Knufenon Don’t Cook Yourself with RF Energy

The chain goes Heat -> Inflammation -> Cancer. It is well known that inflammation causes cancer. It is one of the biggest and often underlooked causes of cancer in obese individuals.

See https://www.google.com/search?q=obesity%20inflammation%20cau...

Knufenon FDA Approves First CRISPR Cows for Beef

This is probably gonna sound a bit dystopian, but would you eat beef if we eliminated suffering with CRISPR? I don't get to talk to a lot of vegetarians/vegans so honest question.

Knufenon Is Old Music Killing New Music?

https://news.ycombinator.com/item?id=29999110

Repost

Knufenon It’s Time to Close Guantanamo

Has any good come from Guantanamo? Like at all? This is not a hypothetical question!

Knufenon Ask HN: How to be my own genetic disease researcher for my partner?

As a medicinal chemist (obviously biased), I would focus more on treatment and alleviation than the genetic component. This would usually mean looking at the metabolism or how the genetic mutation alters it. Is your partner lacking an enzyme, certain metabolites or intermediates etc.? These can at times be supplimented either directly or indirectly through food or vitamins/co-factors.

Knufenon Nobel Prize: We will not have gender or ethnicity quotas – top scientist

> Then, considering your answer above, how does that match to reality? What accounts for this mismatch? Why are fields (and awards like this) underrepresenting our populations?

Isn't that obvious? Nobel prices (especially science) often have a lag time of 50 years (semi random number) and is also often given to middle aged people. So since science has been dominated by white guys we will see almost all Nobel prizes given to white guys. I expect this to change in 100 years as more women enter STEM and then with some added lag time.

Knufenon Minecraft is helping children with autism make new friends (2016)

What does "white washed form of eugenics" mean? Legitimately curious!

Knufenon A Chemical Hunger – Part V: Livestock Antibiotics

>This is nonsense - there is no way to predict weight gain based on calorie intake - variance between people is too huge on this metric - individual BMR alone varies between 1000 kcal/day up to 2500 kcal/day.

Please site your sources. A variance of basal metabolic rate (BMR) of 2500 kcal/day sounds too extreme to be true, but I am open to learning something new. At least according to (https://examine.com/nutrition/does-metabolism-vary-between-t...) the variance in BMR is only around 300-400 kcal/day which makes your number unbelievable high.