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Ah, I see, thanks. Still, that's a non-starter. Many of the packages I use are not available through any system package manager, and it would preclude using virtualenvs.

OTOH, I desperately want to move away from Python.

The problem is, I am using the package manager (pip in this case). I guess because the wheels aren't built for SmartOS it has to compile them.

I really wish I could use SmartOS, but I couldn't even install some common Python packages without getting a compilation error. Looking such problems up on issue trackers revealed old requests for compatibility with SmartOS, and no follow-up from the developers.

I'm not sure what the recourse is, I just don't know enough about C to fix this myself. I assumed this would be a common enough problem that the solution would be well documented somewhere but there seems to be nothing out there even mentioning the issue.

I'm happy to do all my work in LX-branded zones, and that's certainly better than the alternatives (for my purposes), but having two operating systems still kinda irks me.

Biophysics and biochemistry would both fit the bill.

I would not take the site you linked seriously - it's the ramblings of a crackpot. If you happen to have a biology background and would like to debate this, I'd be happy to elaborate.

Is there anything more to it than carving a piece of silica and ligating the adapters to the surface? I mean, I know the process is a bit more involved than that but the patents make it seem relatively straightforward.

This is a huge red flag for me. Maybe if you made your own bootleg flow cells and reagents? But even that seems like a stretch.

That's fair, my generalization was pejorative. I meant to say, in a glib way, that this is not a website frequented by 100% licensed physicians and clinical researchers, and is actually mostly not that.

The point is, the OP is essentially saying, "I wish to discard the notion that statistical research is valid and may make medical decisions based on a study with N=1 or 2". I was worried people would show up and offer magical cures as they always do, and lo and behold, there are threads suggesting hypnosis and turmeric.

My main concern with this is that the OP may use a completely arbitrary "cure" and avoid speaking further to doctors about it, so any actual treatments that are developed might be overlooked.

It can also make things actively worse - it's not just additional information, but potentially disinformation.

I can't help, but I can guarantee you that getting unlicensed medical advice from web developers won't make things better.

Cpf1 is patented, it's just that there's no dispute over who owns it.

No. Working around this takes some effort but is straightforward and uses well-known, existing techniques. There's a lab I know of that considered trying to modify the protein so it could evade the immune system, but they decided against it since they figured the group that published this paper would have too much of a head start and there's no way they'd be able to compete. I'd give it a year or so, and that's assuming none of the other Cas9 or Cas12a variants are already usable.

I've been happy just dual-booting Windows and Linux. Windows 10 is free as long as you don't care about personalizing it, which I definitely don't, since it's just for games. I look forward to having a Linux-only machine but I'm not in any hurry.

Also, consider this from the manager's perspective. They have to ask themselves: if this person has 35 years of experience, they must have a substantial network, so why aren't they just tapping that resource? Not a single person from this applicant's past wants to give them an interview?

> So the input for this technology is imaginary.

They proposed one use, which would be to use it as storage for solar/wind power. Perhaps their plan is that when there's excess output from renewables, they'll use electrolysis to generate hydrogen gas from water?

I did see a video that explained how to correctly handle high pressure gas cylinders, which did teach me some critical things on not getting myself or others killed.

I was also surprised by this. In the papers where they did this work, they discuss many previously-known mechanisms for intercellular mitochondrial transfer - apparently cells can form nanotubes and exchange organelles, and that's relatively well-studied. That's not what's happening here, though, and they state that the mechanism at play is unknown.

Are you able to send them a copy of their individual location data, or the location data of their staffers/friends/family? That might make for a potent wake up call. Though, you'd want to run that by an attorney first.

Is there a reason ISPs would be reluctant to discuss their motivations for IPv6 deployment? That is, why can't you just ask them?

I dunno...academic funding is dysfunctional and this kind of hyperoptimistic prediction can help you get your next grant.

I understand why it's necessary, but I was shocked that he uses piranha in his home garage. I cannot echo the above sentiment enough.

The danger of using CRISPR could have, in principle, been worse than it turned out to be, sure. But the fact is, CRISPR has been used to modify living organisms, and those organisms don't have any more mutations than average, and they seem to be just as healthy as unmodified organisms (unless the edit itself is deleterious).

We might find out some day that there's some behavior of DNA and DNA-binding proteins that CRISPR interferes with, but if it does exist, the effect has to be small enough that we wouldn't notice it.

edit: I should clarify, there's still work left to do to ensure CRISPR's safety. It needs to be looked at in more cell types, and work in somatic cells in adult organisms is still in its early days. My point is just that putting CRISPR into a cell, in some scenarios, doesn't cause substantial problems.

Also this: http://www.cell.com/cell/fulltext/S0092-8674(17)31451-4

> Not everyone can afford to perform their own product analysis.

Just because ethical behavior is expensive doesn't mean you have a license to do whatever you want.

> it’s really a matter of maybe 5 to 10 years.

So...not holding my breath.

The author is missing a major point: politicians may still support enormous projects like the LHC for the same reason they would support any pork barrel project: it gives them influence and the ability to direct money to their friends/constituents.

Sure, but everyone is accumulating mutations all the time, so you need a control on the ground to see if space itself is affecting the mutation rate.

Genuine question: Are there non-toy-related uses for AR/VR that exist? Or is that typical assumption that the applications will emerge only once the technology exists?

Not true. Optimization of chemistry is going to happen unless explicitly hindered by something else. Here, they basically crippled a protein that increases the fidelity of protein synthesis, so there's a fitness advantage to any bacteria that can increase the effectiveness of the ancestral version. It wouldn't matter if the bacteria were in a swamp or someone's intestines or a petri dish - better protein synthesis is always better.

In theory, yes, but delivery of the CRISPR enzyme to all the infected nuclei is still an unsolved problem. Also, it doesn't cut its target every time it does get in - some of the protein is inactive (probably just broken/malformed/misfolded) - but increasing the dose to compensate leads to more instances where it cuts the wrong target.

There's a guy at my work who has a mild stutter. He starts every talk out with something like "My name's such and such, I have a mild stutter so don't let that bother you" and then immediately starts his talk and never mentions the stutter again. It's a smooth and quick transition, but most importantly he actually gives good talks - tells jokes, is passionate and knowledgeable, has informative and clear slides, and really makes it easy to understand his data.

The thing is, most talks are garbage. The audience really is rooting for you, because they're just desperate to hear anything interesting or see a slide that isn't just bullet-pointed text.