There's a guy at my work who has a mild stutter. He starts every talk out with something like "My name's such and such, I have a mild stutter so don't let that bother you" and then immediately starts his talk and never mentions the stutter again. It's a smooth and quick transition, but most importantly he actually gives good talks - tells jokes, is passionate and knowledgeable, has informative and clear slides, and really makes it easy to understand his data.

The thing is, most talks are garbage. The audience really is rooting for you, because they're just desperate to hear anything interesting or see a slide that isn't just bullet-pointed text.