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238475235243

118 karma · joined May 29, 2019

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238475235243··on AirTag leads to arrest of airline worker accused of stealing from luggage
If I install something (tile?) on my android, will it help people find their airtags (and tiles)?

I'm happy to run it for fun but don't know what to run.

238475235243··on Marc Andreessen and Ultra-Wealthy Neighbors Thwart Housing in California Town
I suggest you try to pretend to build a house, condo or office building to see what happens.

Just go through the motions, talk to builders and try to get permits.

Then you will understand.

238475235243··on Downtown S.F. on the brink: It’s worse than it looks
Not one mention of the recalled DA.
238475235243··on Ask HN: Career change for elderly UK ex-convict?
Start a Ltd company and use that to find work on Upwork.
238475235243··on Deleting an S3 Bucket Costs Money
Yes but some of us have many billions of objects. From memory, 4 billion object is $20k to delete.
238475235243··on Squirrel stores thousands of nuts inside man's parked truck
Hold on. That means you have a lot of stories! What CM-5 things did you do!?
238475235243··on Scotland Joins the Growing Global Movement Towards a Four-Day Workweek
https://knowyourmeme.com/memes/most-people-rejected-his-mess...
238475235243··on Scotland Joins the Growing Global Movement Towards a Four-Day Workweek
It's not like Scotland was exactly the home of efficiency and productivity to begin with... But good for them! I look forward to visiting and taking a dram on the occasional day when they're open.
238475235243··on Alibaba to invest $15.5B for “common prosperity”
If you read a biography of Ford you'll find this story just isn't really true. He couldn't find workers and had to raise the wages, and in doing got a lot of PR by spinning it as being good for workers to buy cars.
238475235243··on Alibaba to invest $15.5B for “common prosperity”
Alibaba isn't doing this voluntarily... They disappeared Jack Ma for re-education and he came back with wonderful ideas about donating all profits to the CCP.
238475235243··on Rent control isn’t working in Sweden
Reminds me of the Pratchett / Discworld song "wouldn't it be nice, if everyone was nice?":

https://www.lspace.org/fandom/songs/wouldnt-it-be-nice-if-ev...

(sung to the tune of "It's a Small World")

If we all were friendly

I'm sure you would agree

That the world would be a better place

For you and for me

And if everyone was kind

I'm sure no-one would mind

So let's all be nice

Chorus:

Wouldn't it be nice if everyone was nice?

Wouldn't it be nice if everyone was nice?

Wouldn't it be nice if everyone was nice?

Let's all be nice.

Being good to people

Is lots of fun

And it makes a difference

To everyone

And a smile is a frown

When it's turned upside down

So let's all be nice.

Repeat chorus ad nauseam.

238475235243··on Police helicopter's 100mph chase with 'super sophisticated' drone near Tucson
UAP
238475235243··on Apple urged to drop plans to scan iMessages, images for sex abuse
Maybe it's the expandable back door reporting mechanism that Apple wants to put in there?
238475235243··on What happens to your brain when you give up sugar
> My rudimentary understanding is that the brain needs glucose to work properly. Especially for intellectual work.

No.

In deep ketosis there's gluconeogenisis where the small amount you need will be made for you.

In fact, people on keto or fasting actually report vastly better mental clarity.

238475235243··on Why airlines no longer use rear-engine planes
Ordered a copy, thanks for this
238475235243··on Why airlines no longer use rear-engine planes
That and center of gravity is why they stick out in front of the wing already for under-wing engines. You'll also notice the cowling slopes down and is not flat to the airflow for the same reason, to ingest air when climbing.
238475235243··on Driving 1725km in an electric car in 2 days
Well so far the sales numbers don't follow your generous assessment...
238475235243··on Driving 1725km in an electric car in 2 days
Genuinely baffled why anyone buys anything but a Tesla.

It's cheaper, autopilot is pretty great, has a vastly better charging network, charges vastly quicker...

I guess it means you can write blog posts about bad experiences with an electric car...

238475235243··on U.S. generates more plastic trash than any other nation, report finds (2020)
Yes but we don't just throw it in a river like many asian countries.
238475235243··on A foreign seller has hijacked my Amazon Klein bottle listing
Just to say I bought one of these as a gift years ago and it was great. If you're thinking of buying one, go for it.
238475235243··on Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis
This is very tiring, and I mean that in a kind way. Honestly, whoever you are.

Let's look at the first Wikipedia sentence on tyrosine kinase as a starting point:

"A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell."

What's ATP? We both know what ATP is. Is ATP deeply part of metabolism? We both know it almost is a definition of metabolism. I want to shout at you. But I don't know who you are or how to connect with you.

Please, for the love of anything that you find Holy, instead of arguing with me on the internet do this: Read the books I recommended, and start looking for the links to metabolism like I just did for you instead of trying to "see DNA everywhere". You will go so much further and help all of us than just arguing with me.

238475235243··on Ask HN: What should I say to my manager when my performance starts suffering?
I've quit and failed out of many jobs and I've also been a manager multiple times of medium-sized teams in highly demanding environments.

I've been on both sides of the table.

My advice isn't orthodox, but it's real.

The first question is, is your manager some kind of psychopath? If they are then just quit and move on. It's painful. Maybe it will work out so you should stay. They're really nice underneath... all that stuff. No. Just quit. It won't get better. They won't change. They won't suddenly care about you. You're done. Move on.

If they aren't a psychopath then just level with them. Be completely honest that you're burning out right now and you need a break, or a different role, or you don't know and you need help. They will either fire you immediately and you can move on, or they'll figure out a way to help you. From a managers point of view this is fantastic - a report is telling you what they need, or they need help. The worst employees are the ones that are just a continual problem. If you flag that you're a short-term problem, or a solvable problem or a problem that needs help this is 1,000x better than someone who's a problem every day.

A good manager is a human being. They truly want to help. They'll ignore or figure out a way around the corporate stuff. If they aren't a human being, just move on. If you are a continual problem, don't be mad if they move on from you.

Most managers, I think, have only had two types of people with "performance problems". Type 1: A real problem. Your cat died. Your parent died. You broke a leg. Your car crashed. You just don't like your role. All of these are ok. We're all human. Your human manager will support you through it and figure out leave or a new role or whatever else is required.

Then there's type 2: You stop coming in. It's not clear what's going on. You don't talk. Different problems every week - your ankle hurts then your dog got bitten by a snake. Then something else and then something else. Then something else. It's endless.

Managers... we just don't really know what to do. There's no clear problem. We try things to help you. We try more things. And more. And more. Then it's six months later and we're burnt out and we fire you. But we don't want to. We're still human. We've been there too.

So help everyone, be clear and up front. If your manager is kind they'll figure it out. If they're not then you're better off moving on.

The medium is also everything. Talk in person, talk over email, talk over chat. Make a phone call. Video. You don't know how people like to communicate. It's easy to take things out of context. Try to connect as much as you can.

But don't be afraid. Just level and see what happens. It might be messy and painful like any human interaction but at least you'll work through it.

Again - yes, there are psychopath managers. They're not confined to fast food restaurants. The sooner you figure out you have a psycho manager, the better. Just move on and pray for them, in the best way. Truly pray for them to be better because you should be grateful you don't live in the personal hell they seem to.

........

on this:

"Hey X, hope you're doing well. Just wanted to check in and see if you'll still be doing N things from here on out, or if you've been spending more time doing ___. If there's anything I can help with please let me know."

They're trying to connect with you and balance the corporate written communication balancing act. Be kind. Video call. Chat in person. Find a way to connect and be honest about what's going on and if they're a good person they will help, and if they're not a good person, leave.

238475235243··on Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis
Yes and no, because it changes how you think about it.

If it's "just DNA" then we should focus on relevant therapies. But this is what we've done for 60 years and it hasn't gotten us very far. In fact depending on how you slice the numbers we've made almost no progress since chemo was "invented".

On the other hand if it's mitochondria and DNA damage is just one possible route, and damage happens all the time, then there are metabolic approaches. These include simple diet changes, metformin and all kinds of other things.

We need to abandon the "just DNA" paradigm. Epigenetics is far bigger than most understand, and DNA is far more malleable than most people know.

As both books (I think) say, the TCGA project was largely a failure for exactly these reasons: DNA is a big moving target and the cell-to-cell variance is very large.

238475235243··on Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis
My bet is because more than one thing happens (some insult to the mitochondria in parallel, say) and/or because the gene is actually expressing something metabolic we don't understand. Seyfried (I think) actually points out the parallel metabolic influence of some therapies that we think are working genetically.
238475235243··on Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis
Damage to DNA and mitochondria is happening all the time, the question is what happens in the presence of high carbohydrate loads. If you read the books they'd tell you this.
238475235243··on Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis
If you're a layperson try "Tripping over the Truth" by Travis Christofferson. If you have some biology try "Cancer as a Metabolic Disease" by Seyfried.
238475235243··on Metformin trial reduces seizures and brain tumours in Tuberous Sclerosis
It is but compliance is generally lower in a world of Coke and donuts. People just want pills.

On the plus side, we're slowly making the public aware that the DNA theory of cancer isn't actually right and that carbohydrate metabolism is much more powerful.

238475235243··on Citing a serious flight test incident, FAA slows Boeing 777X certification
Pretty much nobody flies the 747 any more for passenger ops.
238475235243··on Preliminary Assessment: Unidentified Aerial Phenomena
> And they all saw the same object from the same perspective

This just isn't true if you listen to their interviews. I'm going to assume you're just the disinformation guy now.

238475235243··on Preliminary Assessment: Unidentified Aerial Phenomena
> but not at the same time.

The initial two F-18's had two people each.

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