Edit: also if you could introduce a change in the cells that only changed the metabolism and didn’t alter DNA you could prove your theorem if you then caused them to be tumorigenic.
If it's "just DNA" then we should focus on relevant therapies. But this is what we've done for 60 years and it hasn't gotten us very far. In fact depending on how you slice the numbers we've made almost no progress since chemo was "invented".
On the other hand if it's mitochondria and DNA damage is just one possible route, and damage happens all the time, then there are metabolic approaches. These include simple diet changes, metformin and all kinds of other things.
We need to abandon the "just DNA" paradigm. Epigenetics is far bigger than most understand, and DNA is far more malleable than most people know.
As both books (I think) say, the TCGA project was largely a failure for exactly these reasons: DNA is a big moving target and the cell-to-cell variance is very large.
The DNA paradigm explains this very well. How does the book explain this treatment?
How about a stem cell transplant? Why do they cure certain cancers? Does the metabolism of the person donating their stem cells get taken up and adopted permanently by the recipient?
Let's look at the first Wikipedia sentence on tyrosine kinase as a starting point:
"A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell."
What's ATP? We both know what ATP is. Is ATP deeply part of metabolism? We both know it almost is a definition of metabolism. I want to shout at you. But I don't know who you are or how to connect with you.
Please, for the love of anything that you find Holy, instead of arguing with me on the internet do this: Read the books I recommended, and start looking for the links to metabolism like I just did for you instead of trying to "see DNA everywhere". You will go so much further and help all of us than just arguing with me.
As to the atp issue, yes it is involved with metabolism but so so much more. If you have time read The Biology if Cancer by R A Weinberg. He does a good job of exploring the historical investigations as wellas the science.