46 karma · joined November 24, 2013
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936261/
Abstract
Bariatric surgery is now widely reported to ameliorate or resolve type 2 diabetes mellitus in adults. Some clinical investigators even suggest its use as an early therapeutic intervention for type 2 diabetes in patients not meeting standard criteria for bariatric surgery. However, little is known about the exact mechanisms explaining the metabolic consequences, and much active investigation is underway to identify hormonal changes leading to diabetes resolution. This review includes a detailed description of various bariatric surgical procedures, including the latest less-invasive techniques, and a summary of current data providing insight into the short- and long-term metabolic effects. We outline current hypotheses regarding the mechanisms by which these surgical procedures affect diabetes and report on morbidity and mortality. Finally, we discuss the available data on bariatric surgery in adolescent patients, including special considerations in this potentially vulnerable population.
https://www.sciencedirect.com/science/article/pii/S019697811...
Abstract
Bariatric surgery for obesity has proved to be an extremely effective method of promoting long-term weight reduction with additional beneficial metabolic effects, such as improved glucose tolerance and remission of type 2 diabetes. A range of bariatric procedures are in common use, including gastric banding, sleeve gastrectomy and the Roux-en-Y gastric bypass. Although the mechanisms underlying the efficacy of bariatric surgery are unclear, gastrointestinal and pancreatic peptides are thought to play an important role. The aim of this review is to summarise the effects of different bariatric surgery procedures upon gastrointestinal and pancreatic peptides, including ghrelin, gastrin, cholecystokinin (CCK), glucose-dependent insulinotropic hormone (GIP), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), oxyntomodulin, insulin, glucagon and somatostatin.
Interesting article about leprino a while back.
Jordan Peterson - Why not just be Child-free and Happy? https://www.youtube.com/watch?v=in4sDT9__0I
I certainly don't notice it easily but I have saved several hundred hours according to it.
7. Toxic chemicals, free radicals, pathogens, trans-fats and other damaging agents you’re exposed to end up in your blood stream, where they damage the endothelium – the razor-thin lining of your blood vessels. When endothelial cells need to be repaired, your liver sends LDL to the site, and when the healing process concludes, HDL carries the spent LDL particles back to the liver to be removed from your body.
https://heartmdinstitute.com/heart-health/facts-about-choles...
Thank you for sharing.
https://suppversity.blogspot.com/2016/05/not-resting-long-en...
Soma, Talos Principle, The Valley, Kona, Firewatch, To the Moon, Everybody Has Gone to the Rapture. Have all been extremely enjoyable experiences.
Really hoping for more to discover in this genre.
I know it has been mentioned in this topic several times but again, anyone with an interest should definitely check out Permutation City. All of these concepts are explored in very entertaining ways.
http://journals.plos.org/plosone/article?id=10.1371%2Fjourna...
Abstract
Western lifestyles differ markedly from those of our hunter-gatherer ancestors, and these differences in diet and activity level are often implicated in the global obesity pandemic. However, few physiological data for hunter-gatherer populations are available to test these models of obesity. In this study, we used the doubly-labeled water method to measure total daily energy expenditure (kCal/day) in Hadza hunter-gatherers to test whether foragers expend more energy each day than their Western counterparts. As expected, physical activity level, PAL, was greater among Hadza foragers than among Westerners. Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than that of Westerners after controlling for body size. The metabolic cost of walking (kcal kg−1 m−1) and resting (kcal kg−1 s−1) were also similar among Hadza and Western groups. The similarity in metabolic rates across a broad range of cultures challenges current models of obesity suggesting that Western lifestyles lead to decreased energy expenditure. We hypothesize that human daily energy expenditure may be an evolved physiological trait largely independent of cultural differences.
Builds some very cool chain of links all leading to Philosophy
Latency Numbers Every Programmer Should Know