valec

won't someone think of the property??!?

ok. your pipe is full. now what

ssris are known to unmask or precipitate manic episodes in people with family history of bipolar or schizophrenia.

> I'm speculating here but I'm pretty sure if you did an MRI on my brain you'd see lesions from the mixing of mdma and sertraline

ssris actually block the serotonergic effects of mdma and similar.

well, they are. outsourcing is the bigger problem. just like outsourcing decimated manufacturing jobs, now it's decimating white-collar. i well and truly hope you get fired so you see how bad the market is. no other profession has this number of cruel, judgmental narcissists not looking out for their own kin.

don't be asinine. h1-b is what enables this exploitation

it's material conditions that lead to violence, not the tools.

sure tools make it easier, but gun control didn't stop the pm of japan from getting assassinated.

if people weren't so desperate, polarized, and angry, i would bet my entire life's savings gun deaths would be decimated

in fetuses.

> Also taking SSRIs near MDMA administration is one of the worst pieces of what is doubtless intended as harm reduction advice I’ve ever seen. You don’t hand people a recipe for serotonin syndrome because of a small scale rat test or two.

you have a deep understanding of releaser pharmacology if you state this. don't take it from me though--matthew baggott, one of the leading researchers studying enactogen pharmacology recommends doing this exact thing

dosed reasonably (~125 mg with no redoses), ideally at lower ambient temperatures, and ideally with an SSRI at the end of perceptible effects to stop MDMA to keep circulating through the neuron and causing oxidative stress, you will quite literally see 0 axonal damage. maybe some neurotransmitter depletion, but this is only temporary.

PCA yes that is concerning but I would be extremely surprised if it ended up in the MDMA supply chain. MDMA is made cheaply at quantities several magnitudes higher than research chemicals. it's much more likely PCA will be sold as a cut for others RC's -- especially as a part of those dreadful cathinone soups labelled "3-mmc" these days

keep user profiles maybe with cookies or by encouraging sign-ups and then use NMF

https://en.wikipedia.org/wiki/Non-negative_matrix_factorizat...

actually, yes, it is extremely hard to determine who finances the political ads you see on TV.

https://en.m.wikipedia.org/wiki/Dark_money

and how is a black box algorithm any worse than a system where only large corporate gatekeepers control what you see? if anything, i'd argue tiktok is more fair and democratic.

should we ban tv too then?

it's interesting you bring that up as it turns out the incumbent party was actually the one behind that tiktok campaign, not russia. the campaign they used as evidence of "russian interference" that they cancelled the election because of

https://snoop.ro/anaf-a-descoperit-ca-pnl-a-platit-o-campani...

well, thankfully there are tools [1]

1. https://www.nature.com/articles/s41586-023-06204-3

terms like "oversocialized" suggest you spend too much time on imageboards and you would do well to get off those sites. same with "humiliation ritual"

lac-phe. https://www.cell.com/trends/endocrinology-metabolism/fulltex...

interesting. i have about 1-2 cups most days but 5-6 over a few hours is fine and i still get ok (but poorer quality) sleep

now if only neotame was mass produced.. (100x aspartame's potency but requires more synthetic steps to reach)

how did you get that from the article?

"One of the common solvents, ethyl acetate, comes naturally in many foods and beverages. It’s considered a safe chemical for decaffeination by the Food and Drug Administration."

speaking from a chemist's perspective, ethyl acetate is basically non-toxic. it decomposes into ethanol and acetic acid (vinegar). dcm (methylene chloride) is toxic, but should be completely removed before it ever reaches you. the nice thing about volatile organic solvents is that they're...volatile, so they are easily stripped from coffee beans.

it does. that's what the "direct preference" part of DPO means. you just avoid training an explicit reward model on it like in rlhf and instead directly optimize for log probability of preferred vs dispreferred responses

to fund it? there are plenty of non-profits with for-profit wings. ACS and CAS for example

i get the opposite take from this info. the fact that, in just 10,000 years, the gene spread to over 1/3 of the population shows how useful of an adaptation it is.

not my problem!

are you serious? reddit is perhaps the most astroturfed platform on the planet.

i pronounce it in my head (wrongly) like xi/shi

more concerning are the effects on muscle tissue

psilocybin (or more accurately the active drug it is converted to, psilocin) and LSD are extremely similar as classical psychedelics. psychosis is possible with any sort of psychoactive drug and individuals with a family history of bipolar disease or schizophrenia should avoid consuming any psychoactive substances. with that said, psychosis is extremely uncommon with LSD in healthy individuals at reasonable doses, and LSD use actually has a slight negative correlation with later development of schizophrenia.

i'm not sure about that particular case, but consuming LSD while on lithium (commonly prescribed for bipolar disorder) essentially guarantees an acute episode of psychosis and possibly seizures so I wonder if that particular individual was on lithium at the time.

it's more accurate to characterize LSD as semi-synthetic, just like thebaine derivatives such as hydrocodone, hydromorphone, and oxycodone. it's a simple one or two step transformation from ergot-derived alkaloids.

it seems like MM120 is literally just the "optimal dose" of the tartate salt (the normal salt LSD is co-crystallized with) of LSD in a pill. it doesn't seem like there's any special delivery device, nor is it any sort of prodrug nor is it a deuterated analogue.

It's decent but nothing crazy. I think most men could achieve it within 4-6 years. Generally, you can build muscle until age 40 without TRT at which point sarcopenia sets in and you lose on average 10% of muscle mass per decade. Thus it's better to have a reserve. When you look at causes of death for old people, there is case after case of falling -> broken hip -> catch something and die in the hospital. Having a good base of muscle makes this significantly less likely.

WRT to injuries: in terms of physical activity, lifting has some of the lowest injury rates, leaps and bounds lower than something like basketball or sprinting. While they are possible, joints adapt to loads over time and having a strong back + spine makes it a lot less likely to pull something in daily life. With intelligent load management (sleeping + eating well, not putting in more volume than you can recover from, listening to your body) injuries are extremely infrequent and generally minor---I have not had a serious injury in the 5 or so years I have been lifting.

I think lifting is too-often overlooked in health discussions, and, given how important avoiding metabolic conditions and immobility is for general health and happiness, I would argue it's just as important as cardio as a physical activity.

These are nowhere near a replacement for weights or machines. I notice you didn't even mention doing pull-ups, the only body-weight exercise with enough resistance for you to actually build muscle from.

Can you point me to a bodyweight exercise that can sub in for 450lb deadlifts for sets of 6? How about for 250lbs bench for sets of 6? While you can build good general health and endurance i n 2 square meters in "the park," you by nature of the exercises are putting a (very) low ceiling on potential muscle mass, which is very important not just for looks but also for general metabolic health (muscles act as a glucose sink, blunting the effects of blood-sugar spikes) as well as preventing frailty/immobility in old age.