Depends on the firm, but there is usually a "lock-up" period of several years where you cannot divest. Sometimes the firms will return the money early if things are getting bad but once the money is deployed they can't risk a bank run because they'd have to fire sale their investments which would be bad for everyone.
Of course, but its an absolute pain when you switch jobs/insurers or move and have to jump through a bunch of hoops to get prescribed the drugs you need to get through those bunches of hoops.
I've been trying out this organizational method for about 2 months now. tl;dr - everything falls into a Project.Area.Resource.Archive (sub)folder and the ideal is to rotate things through as soon as they're finished to Archives where you can ~forget about them. What I appreciate about it is how its recursive, so you can organize individual projects according to the PARA rules.
I agree with the author that its difficult to decide between Areas and Projects and appreciate his take that all Projects belong to an Area - insightful. One of the changes I've made to the system is to refer to Resources instead as Records. I like to take daily notes and keep to-do lists, summarize/link articles etc which usually have some type of temporal resolution and may not always fit in a specific project/area. So far I like it better than my old method of categorizing things by date and type and it meshes well with my fairly simple Obsidian environment.
Siderophores are some of the craziest things in biology, in my opinion. Short peptides (often <10 amino acids) with affinities to metal irons that are just incomprehensibly low with binding so tight you can actually deplete metals from water - 0 atoms per liter. An excellent technology for future e.g. heavy metal/nuclear contamination remediation
On this topic, I would highly recommend Nick Lane's Oxygen: The Molecule that Made the World. Interesting learning about how life worked different when oxygen was much lower, and much higher than today.
I love ideas around extracting minerals from seawater since there is just so much. e.g. estimated 4.5B tons of uranium in seawater, ~1000x higher than land sources. Pretty much everything is dissolved in there, but the energy requirements are insane
Had to find the article, but I recently read this: https://commoncog.com/cash-flow-games/ talks about the guy who invented EBITDA and I found it super informative. Explains WHY profit is a bad measure and why cash flow rules.
Thats true, but we do tremendous amounts of human DNA sequencing for certain causes at scale(e.g. understanding/treating cancer) whereas environmental sequencing is usually done to monitor/search for things at a much lower sample rate(e.g. disease load in wastewater, biodiversity from environmental samples, and looking for natural products produced by the zillions of bacteria/archaea in the oceans). From e.g. a wastewater sample perspective the latter type is going to be the majority of data, we just filter out the stuff of interest and analyze it in situ - but theres no reason to store 1B E coli genomes whereas this is necessary if we want to understand cancer evolution.
Very good news to hear. With recent energy problems being exposed via the war in Ukraine, nuclear power is increasingly our best option for cheap, abundant energy. Despite decades of misdirected "Green" propaganda, nuclear is the safest, most viable route to a carbon-free future, while renewables are just not ready to scale yet (let alone their massive footprint compared to nuclear). Just hope we can get these in the ground fast enough to make a difference.
Can confirm that the data is often, though not always, stored in a shared directory and that yes, many tools can/do read gzip files directly which probably hinders the adoption of better compression algorithms.
Well I think the issue with wastewater and other screening tech is that there is no global average reference genome. In that case they're sequencing everything from phages, viruses (human and plant), bacteria, fungi, plants/animals and human...its an everything soup.
That would be true for FASTA compression but FASTQ files contain other data. With a MiSeq, for example, 1/3 of the data is the DNA sequences, 1/3 is a quality score (0-37) and 1/3 is a header which includes things like flow cell ID but also a lot of info on the physical registration address of the cluster on the flow cell. In some applications this info is not required, but is from a scientific/data integrity perspective
I was only replying to "So less than 12 of the components were manufactured in Asia, while 40 have been manufactured by US companies." My point is that the nationality of a company has no bearing on where they manufacture their parts.
But while yes these companies should bear responsibility if they are selling their parts to sanctioned countries, this is unlikely. There is just no way to track the real-time user of every commodity product - even if there were would you really want to live in that world?
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I follow pretty closely and have not seen any evidence or heard any rumors that there are any reputable banks with significant direct exposure. Many of the banks that might fall would be ones whose primary customers are people in the crypto space but really its all shrouded in mystery. VC firms and PE, on the other hand, are probably going to see a lot of bloodshed
In that case you "own" a paper bitcoin, which is much the same as not owning one at all. In this case, the "bitcoin" you own doesn't even exist (outside of the exchanges database) so you cannot use this to speculate on actual bitcoin in actual wallets.
Just look at FTX - some 1.8B in BTC liabilities but zero BTC assets