340 karma · joined November 24, 2015
But also, from the article: "Based on some of 23andMe’s newer hires, we wouldn’t be shocked to see the company dive into drug development, either."
Also, there's often nothing you can do behaviorally. Even people with near perfect behavior will eventually get Cancer or Alzheimer's or Heart Disease. Most of the drugs approved to treat these diseases are something like band-aids that decrease your risk 10% or allow you to live a couple months longer. Maybe too many people are making drugs that work barely well enough for the side effects to be worth it. But almost anything that can get past the FDA will work economically, since there are usually very few alternatives from the buyer's perspective.
One might think drugs would be more dangerous if the FDA were less conservative, but I suspect the opposite. If it takes you ten years and 2 billion dollars to release a new drug, and then you find out it has some terrible side effect in 0.1% of the population, you don't get to fix the problem. You might not withdraw it either, since the drug would still be a net good for society. And if one drug is approved instead of ten, patients are forced to stick to the flawed solution.
The far bigger problem than drugs with side effects is a lack of drugs. Around 1/3 as many drugs get approved today relative to 1970, and the costs of a drug approval have risen 5 times faster than inflation since then. Medicine has been an anti-technological field for the last few decades - it's doing less with more. The most valuable biomedical companies are the ones that have been around since the 1800s - one could imagine what computers would look like today if IBM were still the largest IT company.
This is interesting. My counterpoint would be that if you rely on AI over programs you lose human-editability and determinism. So fixing a bug or adding a new feature might mean diving into some opaque model rather than adding a few lines of code. You couldn't do anything where consistency is important, like security, manipulating a database with important information, or GUI design. I think that at least protects large swaths of software development.
Even this example seems less like a replacement for Photoshop and more like a cool new feature Photoshop could add
Yeah, I don't think many people will care about the difference between good and perfect. You might be able to find a niche in search that Google is ignoring, but you would have a hard time expanding from there into general search.
In that sense Google is a bet against technology - you would invest in Google if you believe the Web's going to stay the same for a long time and nothing will replace it.
So the tools we have now aren't total frauds, and there's probably more to be discovered.
What all three of those examples have in common is that they involve an AI assisting human decision-making. I think that this will be the most lucrative area in the future as well. If you have a set of data a human can't even look at, like a million web pages, the AI doesn't have to be that good at processing it to be useful, since it has no competition from humans. On the other hand, it's rare that you ever need to come up with a million new concepts - you probably just need one. So humans easily outcompete AI at coming up with new ideas. Maybe it's a bit vague what "new ideas" means, but certainly if you're capable of generating new ideas, then you're at least generating turing-complete outputs. Nobody is even trying to do that right now. In the case of image recognition, there are some complex ideas needed to make it work, but at the end you're just outputting a label, getting your model to use the most basic DSL possible.
> there is substantial evidence supporting a holographic explanation of the universe—in fact, as much as there is for the traditional explanation of these irregularities using the theory of cosmic inflation.
This is a bit misleading, especially the phrase "substantial evidence". I bet that the authors of the paper would not have used this phrasing. From the paper:
> We emphasise that the application of holography to cosmology is conjectural, the theoretical validity of such dualities is still open and different authors approach the topic in different ways.
Essentially, their paper shows that a holographic model cannot be ruled out simply by comparing the predictions it makes for the CMB to observation. It also gives some intuition for why a holographic model might make sense - at sufficiently early times in the Universe quantum and gravitational effects begin to coincide, and in other contexts people have modeled quantum gravity using "a quantum field theory with no gravity in one dimension less". The paper finds, however, that there is no empirical case to be made for discarding the standard model of inflation:
> We see that the difference between evidence for [the standard model] and HC predictions is insignifcant, with marginal preference for HC, depending on the choice of priors.
Whatever goals the AI has, it will certainly be better at achieving them if it can stay alive. And it will be more likely to stay alive if there are no humans around to interfere. Now you might say, why don't we just hardcode in a goal to the AI like "solve aging, and also don't hurt anyone"? And ensure that the AI's method of achieving its goals won't have terrible unintended consequences? Oh, and the AI's goals can't change? This is called the AI control problem, and nobody's been able to solve it yet. It's hard to come up with good goals for the AI. It's hard to translate those goals into math. It's hard to prevent the AI from misinterpreting or modifying its own goals. It's hard to work on AI safety when you don't know what the first strong AI will look like. It's hard to prove with 99.999% certainty that your safety measures will work when you can't test them.
Things will not turn out okay if the first organization to develop strong AI is not extremely concerned about AI risk, because the default is to get AI control wrong, the same way the default is for planets to not support life.
My counterpoint to the risks of more limited AI is that limited AI doesn't sound as scary when you rename it statistical software, and probably won't have effects much larger in magnitude than the effects of all other kinds of technology combined. Limited AI already does make militaries more effective, but most of the problem comes from the fact that these militaries exist, not from the AI. It's hard for me to imagine an AI carrying out a military operation without much human intervention that wouldn't pose a control problem.
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I've always felt that these explicit calculations don't really get to the point. You can memorize them and still not really understand what's going on.
Things like the fact that squared error is differentiable are actually irrelevant - if the best model is not differentiable, you should still use it.
What Tesla has done so far with "autopilot" is a big deal, but releasing a "video of a car driving itself" is the classic marketing trick with machine learning, where you cherry pick aituations in which your system does well, and most people don't second guess it.
He believes that most of Silicon Valley is naive politically, and that the popularity of social liberalism there is just a moral fashion. He is a liberarian, and believes that the Valley's instincts are libertarian, not liberal. He has a slightly pessimistic outlook on the future, and believes that America has been falling behind since 1969, "when Woodstock started... and the hippies took over the country". That aligns well with the central point of Trump's campaign - America has started losing and we need to "make it great again".
He's often said that one of his favorite interview questions is, "tell me something you believe to be true but which nobody agrees with you on". His support of Trump falls into that category. 40% of the population agrees with him, but the people closest to him see his opinion as unthinkable. He seems to take pleasure in having opinions like that. He has said that he believes climate change is "more pseudoscience than science", roughly agreeing with Trump. Thiel backed up his position by saying "whenever you can't have a debate, I often think that's evidence that there's a problem".
He likely sees the stories that have come out against Trump recently as worth ignoring when the future of the country is at stake, and Trump is the only candidate who can focus the national agenda on the right issues.