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tosseraccount

1,641 karma · joined December 9, 2011

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tosseraccount··on Vagus nerve stimulation significantly reduces rheumatoid arthritis symptoms
"several thousand" is "list price" for single shots and no or fake health insurance. In practice insurance companies negotiate the price down and average patient pays much less than that. Major drug makers are ready to go the second the patents expire. Prices should drop dramatically for something like Humira (adalimumab) and biosimilars.
tosseraccount··on Vagus nerve stimulation significantly reduces rheumatoid arthritis symptoms
Anti-TNF biologics are a thing: https://en.wikipedia.org/wiki/TNF_inhibitor
tosseraccount··on Vagus nerve stimulation significantly reduces rheumatoid arthritis symptoms
PNAS journal link here : http://www.pnas.org/content/early/2016/06/30/1605635113.full... : "Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis".

"In one circuit, termed “the inflammatory reflex,” action potentials transmitted in the vagus nerve inhibit the production of tumor necrosis factor (TNF), an inflammatory molecule that is a major therapeutic target in RA. Although studied in animal models of arthritis and other inflammatory diseases, whether electrical stimulation of the vagus nerve can inhibit TNF production in humans has remained unknown. The positive mechanistic results reported here extend the preclinical data to the clinic and reveal that vagus nerve stimulation inhibits TNF and attenuates disease severity in RA patients."

tosseraccount··on UK scientists dropped from EU projects because of post-Brexit funding fears
Private, endowment and British funds can make up for the EU. Getting out from under EU regulations and negotiating as a free agent is a better deal for most Brits.

[ edit: must have touched a nerve. +1 to -4 in an instant. ]

tosseraccount··on Inside an L.A. OxyContin ring that pushed more than 1M pills
The majority of the population has used drugs illegaly. You're saying "we aren't in control of ourselves" ? Most folks can handle a joint or an oxy or an underage brewski.

Abuse should be treated as a medical problem, not a criminal problem. We need to take the cops and lawyers and the prison industry out of fixing it.

Implementing the drug laws in practice targets the poor and minorities.

tosseraccount··on Brexit Is a Lehman Moment for European Banks
"Bank Vaulations [are] weird"

So are private Silicon Valley valuations.

tosseraccount··on The Brexit hangover has left UK startups drained – Are the brains next?
Almost open: https://en.wikipedia.org/wiki/California_Department_of_Food_...
tosseraccount··on The Brexit hangover has left UK startups drained – Are the brains next?
Leaving the harsh regulations of this customs union can benefit Britain and non-EU trading countries. They're better offer negotiating as a free agent.
tosseraccount··on Year-long road trip where it's 70°F every day in North America
check : https://en.wikipedia.org/wiki/Medell%C3%ADn#Geography_and_cl...

average high is 27 centigrade. average temp is about 22.

tosseraccount··on Growing Unease as British Mutual Funds Block the Exit Doors
"The Big Short" Scion Fund managers restricted withdrawals, too.

[ http://www.nytimes.com/2007/03/09/business/09insider.html ]

Either way, chaos created opportunity and Scion investors might feel lucky that they were locked in the castle.

The subprime mortgage market finally imploded causing the Great Recession.

If you are confident of credit crisis, perhaps you can do your own shorting.

tosseraccount··on Investing Returns on the S&P500
For most practical purposes, there's not much difference between ETFs and Mutual Funds.

Some point out some greater risk in ETFs because they can lend their securities : http://www.etf.com/etf-education-center/21031-understanding-...

tosseraccount··on Investing Returns on the S&P500
"this is a zero-sum game"

Minor quibble. That is not accurate.

You see teenagers buying hotdogs with a credit card. Visa and Mastercard go public, you buy shares, it goes up, up, up.

There's no zero sum here and people can spot special values without deep analysis.

tosseraccount··on The life of American workers in 1915
tariffs were the largest source of federal revenue from the 1790s to the eve of World War I, until it was surpassed by income taxes.

source:https://en.wikipedia.org/wiki/Taxation_history_of_the_United...

tosseraccount··on Will Brexit break Emerging Markets' back?
Independece for Britain is a good thing. People didn't like the rigged trade agreement. It wasn't benefiting them. It was benefiting the elite in London. Cheap jobs may be good for the rich, but not for the working folk.

Labor and Conservatives just didn't take the concerns of the majority seriously.

tosseraccount··on The British are Googling what the E.U. is, hours after voting to leave it
Switzerland should be compared with their closest money ~handling~ competitors : Cayman Islands and the Channel Islands.
tosseraccount··on The British are Googling what the E.U. is, hours after voting to leave it
This is the smug style in the new politics.

The notion that the people don't know what's best for them.

Bottom line is the working man hasn't cashed in like the global elite and their sympathizers.

tosseraccount··on Thorium
Could use a fact check too. Atom was first split by humans in 1938, not 1945.
tosseraccount··on Home Depot Files Antitrust Lawsuit Against Visa, MasterCard
American Express sued Visa and Mastercard in 2004: http://www.nbcnews.com/id/6494456/ns/business-us_business/t/...

They settled in 2007 : http://www.nytimes.com/2008/06/26/business/26credit.html

Mastercard paid $1.8 billion, Visa paid $2.1 billion

MA and V have way outperformed AXP since.

tosseraccount··on San Francisco Is Preparing for Life After This Tech Boom
Cash is in the bank being lent out to others. This is good for the economy as a whole.

Saving for a rainy day is prudent fiscal policy.

tosseraccount··on A Renegade Muscles in on Mister Softee’s Turf
The real NYC pizza war: http://kottke.org/11/04/the-mafia-and-nyc-pizza-cheese

Al Capone -- who owned a string of dairy farms near Fond Du Lac, Wisconsin -- forced New York pizzerias to use his rubbery mob cheese, so different from the real mozzarella [...] this is why John's Pizzeria on Bleecker Street still has the warning "No Slices" on its awning today.

tosseraccount··on Tor Browser 6.0 is released
Isn't a lot of this longer routing of packets?
tosseraccount··on Eric Holder says Edward Snowden performed a 'public service'
Leading poltical figures in the other party reported that Iraq had WMDs and used such arguments to wage war on Iraq before Bush.

http://www.snopes.com/politics/war/wmdquotes.asp

https://en.wikipedia.org/wiki/Bombing_of_Iraq_%281998%29

tosseraccount··on The Delightful Perversity of Québec's Catholic Swear Words
zounds crikey blimey godamit gadzooks egad darn

English ha[s,d] the same thing.

tosseraccount··on The New Activism of Campus Life
Yale won 27 collegiate football championships. Princeton won 28 . Harvard won 12 . Standford won 2 .
tosseraccount··on Mars may be emerging from an ice age, according to a new study
consensus != truth
tosseraccount··on They knew it was round, damn it
2 years' provisions

Magellan Voyage took 3 years.

tosseraccount··on They knew it was round, damn it
Earth was simply too large to sail around the other way.

Yet ... 27 years after Columbus' first voyage, the Magellan expedition started it's circumnavigation sailing west proving it was possible.

There are plenty of islands in the Ocean to load up on food and water. Magellen, in fact, stopped at several islands.

tosseraccount··on N.F.L. Tried to Influence New Concussion Research, Congressional Study Finds
NFL is pretty tame. This is tougher : http://deadspin.com/crazy-ass-italian-sport-combines-rugby-w...
tosseraccount··on Balde: a microframework to develop web applications in C
C may have some shortcomings, particulary policing memory vioations, but can be very lightweight and very fast. Remember, Linux and Apache/NGINX are in C . Implementing the site specifics in C isn't that much of a stretch. The extra speed could even make your site that much more useable.

The canonical genome browser is written in C: http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19 ... for pure speed.

tosseraccount··on How Freddie and Fannie Are Held Captive
Banks got into it because the government was guaranteeing it.

Make a loan, collect the fee, dump the junk on the tax payer.

Government enabled and subsidized this. And still does. Home loan deductions, anybody?

We didn't have to "bail them out". We should have let them go chapter 11. Plenty of folks with responsible finances could have bought up the assets.

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