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throwaway330935

6 karma · joined May 13, 2021

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throwaway330935··on Thinking in Python
I've used and been involved in my Python community since the late '90s, and I wish I could say you're totally off the mark here, but... It hits closer to the mark than I'd like. There is a subset of the Python community that I dearly love, but these days the bulk of the Python leadership makes me reluctant to be involved with it.

I guess maybe it's a time marches on thing and the leadership serves a very different community than the one I remember. Which is fine if that's what's happening. But I'm not entirely convinced that that is the extent of the story.

throwaway330935··on I'm OK being left behind, thanks
>what's the point of "getting in early"?

You're trying to make the point using BitCoin, but in the early 2000s I had just over 14,000 of them, so I can quite clearly see a point in getting in early.

throwaway330935··on Psilocybin decreases depression and anxiety in cancer patients (2016)
>Welcome to year 30 of trying to prove psilocybin works for psychiatric illness.

That is true, but it misses some important nuance: the war on drugs has effectively eliminated the ability for legitimate researchers to do significant research on these criminalized drugs.

For example, for me personally, a mild dose of marijuana is as effective as Zolpidem (Ambien) as a sleep aid, but without the lethargy and mental fog the next morning.

throwaway330935··on Psilocybin decreases depression and anxiety in cancer patients (2016)
I've been doing some recent research and testing, and here's what I have found: I'm talking about the "Penis Envy" strain, which is quoted as being ~30% more potent than typical. 2g is the edge of where I start getting visual artifacting, and only sometimes. 3g, which I have not tried, was quoted as being towards the upper end of a "theraputic dose", and 6g as the upper end of a recreational dose. Some friends with much more experience consider 1g to be microdosing, FWIW. 0.25g I can't feel at all. .5g I start to feel some euphoria and 1g to 1.5g I start to feel "high" but with no noticeable psychedelics or just minor visual artifacting when I'm reading.

I don't really have anxiety or depression. I do have a fairly high stress family life, wife and kiddos have lots of issues. A few weeks ago I had 2g on an empty stomach on a Sunday and I just listened to music for ~4 hours and it was like I had a vacation. I hadn't enjoyed listening to music so much for 20-30 years. Also, I seem to feel kind of sleepy when I'm trippy, but afterwards I'm wide awake for 4-5 hours. So evening dosing is best avoided.

It's kind of great, for me personally, living in a state where it has been decriminalized.

throwaway330935··on Psilocybin decreases depression and anxiety in cancer patients (2016)
I learned from an episode of "The Studio" that by "an eighth" you are likely referring to an eighth of an ounce is around 3.5 grams. Dude thought he got really mild shroom laced chocolates ("an eighth of a gram") and much hilarity ensued.
throwaway330935··on Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching
I'm currently working on losing weight and having a fair bit of success, largely because my wife is also extremely serious about it now. I'm basically feeding off her success, and supporting her is making it easier for me to make changes in my diet.

Over the last 2 months she's lost almost 30lbs, and I'm at over 20. Largely this has been serious changes in diet: Little to no carbs, basically a lot of grilled veggies, Soylent, protein drinks, yogurts, fruits... A little more exercise.

Really, the trick has been: She got a sleeve surgery a week ago, and for around 6 weeks before that she was basically on the reverse after-surgery diet to get used to it. And I've been kind of following her diet, though she encourages some tweaks to make sure I'm getting what I need. And this week when she's been just having a cup of broth a day, I've not been anywhere near that.

Short story long, She's on this path enforced by surgery. I want to support her, but I also want to use her journey to help me with my own. I'm fairly healthy, but want to make some activities easier, and I've been having some arthritis in my hips that make me want to ease their burden.

Fella sounds interesting as a way of further supporting my journey. Sounds like it's not available outside of TX, which I assume is related to "board certified". Also a little hard to tell what the final cost is going to be, $450/quarter plus whatever the drug is? I saw one of the other similar drugs on goodrx at $1K (a month? a quarter? Not sure), but looks like my insurance might cover it to the tune of ~$100. Boy, sure hope there's no tie to pancreatic cancer though. :-)

On the one hand, extra support might be nice. On the other hand, we've been going for 2 months and I'm about 20% of the way to my goal, and it hasn't been so hard, but I could also see it getting harder. I've previously lost almost double what I've lost so far, and then plateaued and gained it back over ~5 years. But now I have my wife going through it as well, so maybe it'll be different? Or maybe not...

At $250/mo for the program and drugs, it seems worth trying, but doesn't sound like it's even an option outside of Texas. Thoughts?

throwaway330935··on Midair Collision over Denver
>in order to get your mixture into the right ballpark

This makes perfect sense. I'm using a kitchen scale to measure the 2-part silicone mixture that I'm using for making toys, not because weight is critical but because it needs to be right for curing. I should do similar when mixing epoxy, but I always eyeball that for some reason. Maybe has to do with cost, it's $10-20 worth of silicone I'm mixing, and usually a quarter worth of epoxy, just due to quantities involved.