4,473 karma · joined January 1, 2022
For example, I'm looking at my HCP's app right now and can schedule a call with my doctors as early as next week for an e-visit. For an in-person visit, it's closer to a month. But they have absolutely been taking my extra office visits due to my condition.
There are various groups who are now using machine learning to predict long covid based on reporting of symptoms and even immune features.
https://www.youtube.com/watch?v=iB5NclIemQ4
https://www.youtube.com/watch?v=VYNMzaZk_iU&t=3203s
Lots of budding research here on long covid / post covid conditions: https://www.youtube.com/watch?v=278vwGkFXRM
1. I would feel taken seriously.
2. I would still be seeing them to check-up on my health.
3. I would be discussing the budding literature to try promising things (i.e. atorvastatin, AT1RB, etc) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9520195/
4. Other patients who are young and healthy are also validated (i.e. we are seeing more of you)
5. etc
The problem with western medicine today is that if you cannot be treated, they want you out of the system. The system is starting to get much better at adapting to these novel health challenges though. I suppose that will happen when there's 65 million across the world with these issues!
> As the COVID-19 pandemic was getting underway in early 2020, doctors in Wuhan, China, began to report that many patients hospitalized with the disease had cardiac injuries. Heart attacks were frequent, especially in patients with underlying risk factors, and there were numerous cases of myocarditis, which occurs when the heart’s muscle layers become inflamed. Roughly a quarter of patients with severe COVID-19 had elevated blood levels of troponin, a protein marker for cardiac damage.
Still was dismissive of covid having any effect on cardiovascular. But you can only learn so much in 60 minutes over 3 months right?
My story I hope shows this exact sentiment mentioned in this article:
> “It’s important to acknowledge that these patients are suffering,” Anagnostopoulos says. “Many of them are young and unaccustomed to being sick or held back in any way from what they want to do. They often feel they haven’t been taken seriously. And what they want to know is that the doctor sitting with them is developing a plan for improvement.”
That cardiologist told me that covid has no effect on the cardiovascular system and the heart cannot feel pain and discharged me to a PCP after running a handful of tests to rule out anything (Echo, EKG, labs, etc)
Now here we are in 2023, I have had long covid for almost 3 years and cardiologists are now admitting they are wrong. This article is pretty telling on the dismissive behavior and the truth catching up to them.
Also this sentence is just strange to me. The whole point of open science is peer review and truth I thought?
> An initial rush to respond to the pandemic produced a flood of observational and non-randomized studies in this area, he says, which spread more confusion than illumination.
The common "streetlight effect" bias comes to mind:
> A policeman sees a drunk man searching for something under a streetlight and asks what the drunk has lost. He says he lost his keys and they both look under the streetlight together. After a few minutes the policeman asks if he is sure he lost them here, and the drunk replies, no, and that he lost them in the park. The policeman asks why he is searching here, and the drunk replies, "this is where the light is".
Saved you a read. I hope Amazon and CostPlusDrugs can disrupt. I also would love to see regulation come to insurance especially with all the horror stories of denied claims/disability/etc even with support from a team of medical professionals.
Just last week there were two significant discoveries:
For what is being found in long Covid for example, a promising hypothesis is viral persistence in the gut causing major dysbiosis and leading to lower production of serotonin. And we even saw the transfer of Alzheimer’s symptoms from an old host to a young one.
I think it just shows how important microbes are in our lives and what a strong influence they have.
https://www.pennmedicine.org/news/news-releases/2023/october...
https://academic.oup.com/brain/advance-article/doi/10.1093/b...
> The microbiome is not a panacea for our health problems. It doesn't explain them all in their entirety. I think it just shows how important microbes are in our lives and what a strong influence they have.
I'm optimistic. With the current AI wave and being able to process datasets once impossible to do, we can at least come up with findings (that we may not understand) but may help us to understand these diseases and life conditions through the lens of trillions of microbes.
I just read “I Contain Multitudes” by Ed Yong where this topic was unsure as there’s only a handful confirmed links to things like depression, obesity, etc. Now it is confirmed for Alzheimer’s. This is extraordinary.
> One particular instance is the long-term symptoms experienced by a significant percentage of COVID-19 survivors, a condition named long COVID by the patients affected (4). Some survivors of acute COVID-19 began reporting symptoms lasting much longer than the amount of time then reported for clinical recovery. Long COVID has caused skepticisms and slow responses, and to date, there is no effective treatment (5). In contrast, there is now substantial evidence that a significant percentage of COVID-19 survivors experiencing ongoing multisystemic symptoms (6–8), including respiratory issues (9), cardiovascular disease (10), cognitive impairment (11) and profound fatigue (12).
> LitCovid has so far accumulated almost 10 000 long COVID articles (https://www.ncbi.nlm.nih.gov/research/coronavirus/docsum?fil...) and nearly 70% of them do not mention long COVID by name in the title or abstract. We have further collected over 800 synonymous terms for long COVID and shared with the community.
This specific HN thread is a very well done publication. There are a number of prestigious institutions researching long covid and have published in nature, science, cell, jama, and more. Use the tool I just linked so you can confirm that. Perhaps you can stop with the ad hominem.
https://academic.oup.com/nar/article/51/D1/D1512/6814452
In his video on the paxlovid trials he doesn't even know what the arm sizes are. Let alone take a minute to read the trial designs:
> The placebo includes ritonavir, which does not have an effect on the virus, but will help ensure people don’t know whether they are in the Paxlovid or placebo group.
https://medicine.yale.edu/cii/research/paxlc-study/
I don't care to further argue with you. I used to like Vinay, for what it is worth. But not anymore.
This is far from the truth. Over 400 long covid publications a month for the last couple years. Science has pushed this forward to be more conclusive and defined.
Covid contrarians like Vinay are nothing but minimizers with MDs. They cherry pick what serves their narrative while ignoring the rest.
Post-acute infection syndromes (PAIS) is an umbrella term. Many fall under this. Long flu(not new, but new research suggests the phenomenon based on long covid research), long rsv(not new, just more recognized when kids get it and develop asthma later in life), long covid, etc. Larger list here: https://www.nature.com/articles/s41591-022-01810-6/tables/1
Researchers are actively pursuing PAIS and the research being done for long covid is making breakthroughs in PAIS and PAIS populations like ME/CFS. It has become so prevalent that this year there have been multiple centers focusing on it. EX:
https://medicine.yale.edu/news-article/post-acute-infection-...
Nobody is skipping likely causes, if anything we are driving forward today on hypotheses that could help all PAIS (i.e. viral persistence, autoimmunity, chronic inflammation, reactivation of latent viruses).
I’m just calling out the fact that your complaint is not rooted in reality.
The studies you refer to are observational tracking people who supplement vitamin D or live in places where they get it naturally more. To say vitamin D is the cure to most things or even long covid is shortsighted and frankly irresponsible. Linus Pauling did that with vitamin C and tainted public opinion on vitamins.
https://clinicaltrials.gov/study/NCT05633472
https://clinicaltrials.gov/study/NCT05356936
We still need to understand the gut <-> brain connection and why trials like prozac or precursor supplementation helps.
It is already inconclusive that SSRIs help acute covid, but no studies have been done for long covid. That's what the researchers are calling out here.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
https://www.nature.com/articles/s41590-023-01601-2
https://www.nature.com/articles/s41586-023-06651-y
https://www.youtube.com/watch?v=z189Z7tS1w4
https://www.youtube.com/watch?v=VYNMzaZk_iU
The researchers here have a specific hypothesis:
> Our animal models demonstrate that serotonin levels can be restored and memory impairment reversed by precursor supplementation or SSRI treatment. While the effectiveness of SSRIs in acute COVID-19 has been a subject of debate,69,70,71,72,73,74 no systematic exploration of SSRIs in individuals with PASC has been performed to date. Our study, together with recent findings linking depression with cognitive impairment in Long COVID75 and the effect of SSRIs on vagus nerve activity,67 call for the assessment of targeting serotonin signaling for the prevention or treatment of neurocognitive manifestations.
This company has never been remote friendly. Posts like this are absolutely despicable because they hire people remotely without the clear intention that they will RTO. That's called lying.
> Further studies will be necessary to investigate the effect of COVID-19 vaccines against post-COVID conditions when administered after a COVID-19 infection.
Lots of back and forth.
> “In our trial at Austin Hospital, patients were given sodium ascorbate into their bloodstream, resulting in promising improvements to multiple organs.”
Oh boy, vitamin C is having a very strange year. First cancer, now sepsis.