subroutine

Isn't, say, 10 days an order of magnitude faster (better) than 100 days?

I think the prevailing current definition is wrt. the average dev. The worst dev could be arbitrarily bad (suggesting the average dev could also be 10x).

You're right about the sufficient sample size.

I agree there are probably no 10x devs. This person took 7 days to (almost) complete this task (which they cherry picked for their self), suggesting the average 1x dev with experience in this domain would take 70 days.

I think it would be more reasonable to call someone a 3 -sigma dev (someone 3 standard deviations above the mean. These would exist because that's how stats work)

> Hometown International, took control of the outstanding shares of Hometown International and a separate shell company, E-Waste Corp., artificially inflated the price of both issuers’ stock through manipulative trading, and used the entities to acquire privately-held companies in reverse mergers, with the intent to thereafter dump their shares at grossly inflated prices.

This sounds kinda like a SPAC tbh.

"Through an open contest, organized by the Wikimedia Foundation, we are inviting the world to create The Sound of All Human Knowledge. This sound will help communicate what the Wikimedia movement stands for — trustworthy, reliable, open, and accessible knowledge for all."

In terms of adult game nights (or potlucks, parties, etc.), the standard etiquette is everyone takes a turn playing host (since there is some cost incurred/liabilities playing host).

Would you feel entitled to attending such social gatherings, even if your house rules are so vastly different than everyone else's they dissuade anyone from coming?

Also, anthropomorphizing, China is not my friend. More like arch rival, perhaps even nemesis. Canada can come over whenever.

If someone's house rules are so strict that nobody wants to hold game night there, yet this person loves playing in other people's (far less restrictive) homes, how long before we stop inviting them?

IMO if TikTok can operate in the US, then Twitter, FB, etc. should be allowed to operate in China. It's the lopsided (potential) to influence the other market/populace that doesn't sit well with me.

Yes - operating in China.

The thing that bothers me the most about TikTok is how it's allowed to operate with little restriction in the US but US-based companies do not have nearly the same level of freedom to operate in China e.g. fb is banned in CPP).

Instead of income based repayment, I would rather see very low interest rates on student loans (like 1.5%). That way everyone pays the full amount they borrow, there is still incentive to repay promptly, borrow less, earn a higher wage, and those with low income can at least pay off the loan interest so their loan does not balloon. And it's simpler.

Another thought I had (not completely fleshed out)... Federal student loans could help cap tuition costs somewhat like medicaid/medicare. The fed offers a fixed amount per semester (say $4k) to each student. The catch is that a uni can only accept fed loans if their tuition is fixed at the cap. (i believe this is how medicare negotiates reasonable prices for meds - "if you want to accept medicare here is what we will pay for Rx, and it's all or nothing").

The author's first point was that anything with a unique ISBN is treated as a different book.

> From a sales tracking perspective, books are published in multiple formats, each with different ISBNs. I wrote one novel, but from a title count POV I actually published 4 books: hardcover, paperback, ebook, and audiobook. Other books have even more formats (mass market version, movie tie-in editions, etc.) and because they all have different ISBNs, they all have different sales figures.

I would like to see stats that collapse across different versions of (largely) the same text (including new versions or editions of text books, and re-releases that include some special commentary, etc.)

As the article says... "This is considerably more difficult with email because of the huge number of companies and services we want to have our updated email address. It takes a lot of time and effort to change your email address and it involves the risk of losing access to some critical service. There are so many of these services in our lives that we don’t even remember who they all are anymore!"

Including a city in the domain seems like it unnecessarily complicates things. If the goal is to provide free access to a more permanent online "identity", people shouldn't be forced to change it when they move.

While I agree with the sentiment, I think some lawmakers in CA think they can get public transportation to rival cities like New York. It will never happen in places like LA/SD unfortunately. There is far too much sprawl. Most ppl in NYC can step off a subway and walk a couple blocks and be at there destination. In SD, where I live, it doesnt seem financially possible.

Recently SANDAG approved a $160 billion dollar Transit Plan. That would equate to $110k per resident if we paid out of pocket; hopefully they can do some financial voodoo so that's not the case.

A few weeks ago SANDAG officials were forced to withdrawal the most controversial part of their plan, a mileage tax that would tax San Diegans for every mile they drive (obviously very unpopular among residents). But, this tax was the main source of funding for the $163B Regional Transportation Plan, so they are forced to find a new funding mechanism. I'm curious what they will come up with.

I thought this effect was so cool I went and bought a few filters to try myself at home. Here's a short vid:

https://youtu.be/0yCtJAgO5gc

Quorn is both a hilarious and genius name.

The cop that heard the backfire would likely be called to testify that fact in court. If they fail to show up, and the arresting officer (a different cop) claimed they made a probable-cause traffic stop based on what the other cop heard, and that cop refuses to testify, the prosecution is going to have a bad time.

I would buy this if there was a kindle version.

This is bad, and it gets worse. They allow products under their identifier system (GS1?) to change entirely. One day it could be a key chain with 100 4-star reviews, the next day the same page is selling a piece of junk smoke alarm, a week later a USB cable or an iphone case. And the case has 4 color options... red, blue, selfie stick, and large.

If that is true, what is the point of this password remover?

Why do you have such a hard on for China or tiktok? As it is, the sword only cuts one-way. A Chinese social media company gets unfiltered access to western markets and populace but China wont allow the same in return. That's not a fair deal; so I say ban tiktok until China decides western social media companies can operate inside China with the same level of freedom that tiktok operates outside China.

In that case I have no problem with the U.S. banning tiktok until China relaxes its laws.

I think it'd be fair (maybe not fine) if China were to allow, say, Facebook to operate in China if Tiktok can operate in the U.S.

The article doesn't mention this, but in my experience playing live gigs the full pedal stomp (1) is significantly better than dimple button style stomp (2). In fact, for me, it's a dealbreaker if a pedal has a dimple stomp. I'm curious if other ppl feel similarly.

1. https://www.roland.com/RolandComSite/media/uk/images/article...

2. https://delicious-audio.com/wp-content/uploads//2016/01/Iban...

Ok, there's more than I knew about. "We found 12 eligible studies in 443 identified records, involving 6736 patients, mean age 71.4 ± 2. We found a small benefit in cognitive outcomes in patients treated with Aβ-mAbs."

So there's a small benefit to using antibody treatment. To me suggests that Abeta is a good target, but antibodies are not a sufficient Rx.

Have you seen a brain at BRAAK stage 4-6?

I don't think mixed results from one or two clinical trials warrants a total pivot (see my first post). But, again, I'm not opposed to exploring novel avenues. Anyone who lives long enough will get dementia, so both broad and deep insights are certainly welcome.

And your big brain idea is that it's all about the tangles not the plaques (but not NF tangles from tau mechanisms; it's actually hard to tell because the alt hypothesis you cited above basically say that it's not diffuse Abeta and NTF, instead it's ABeta and NFT inside neurons.

NFT and Abeta are part of the traditional AD diagnosis. NFT studies have seen no lack of funding. But for the record, I do think tau plays a role. I'm not sold either way on ABeta or Tau (maybe both).

"synapse loss" is a better correlate for dementia because, obviously. But synapse loss is the outcome of the disease, not the cause of the disease.

(1) We know that "pathological levels" does not always result in symptoms across many diseases. E.g. Plenty of people walking around with pathological levels of coronavirus are asymptomatic.

(2) Amyloid plaques are not the only thing that causes dementia. However genuine AD diagnoses are confirmed post mortem via autopsy and are typically assigned a BRAAK score (most large scale studies require plaque confirmation for cohort inclusion; i.e. AD definitionally requires amyloid presence).

(3) From the large datasets I've worked with, BRAAK score and AD age of onset are HIGHLY correlated. I'm genuinely curious to hear what biomarkers are more correlated.

(4) What is clear-er?

(5) Agree LOAD and EOAD are not identical diseases.

AD researcher here (late to the thread). As much as I loath the 'cabal' mentality, I personally think amyloid-beta is the cause of AD. Just because a few treatments focused on Abeta haven't cured AD isn't convincing in the slightest that Abeta accumulation is not a causative mechanism. (1) AD is a disease of the elderly - a group not particularly receptive to treatment, (2) AD pathology is likely due to a sequelae that took decades to manifest into symptoms; undoing tens of years of buildup is not going to be easy, (3) even if the treatment could clean up a large portion of Abeta accumulation (and that's a big IF) it wont restore lost memories.

With regard to evidence, the article mentions APP gene variant causes early onset AD; but there is another variant in the APOE gene that is the strongest genetic risk factor in late-onset AD. This gene too is in the Abeta buildup pathway.

With that said, I think that NIH study sections allocating AD research funding should not give preference to a particular molecule or theory. If the Abeta hypothesis is indeed the most compelling, grants focused on Abeta topics should naturally be stronger. They shouldn't need any additional bias to stand out.