I think it would help to try and secure signing infrastructure as much as possible. First of all, try to have 3 devs for any given project (this is the most difficult step). Make sure logging into or changing any of the signing stuff requires at least 2 of the devs, one to initiate the JIT and one to monitor.
Additionally, take supply chain steps like requiring independent approval for PRs and requiring the signing process to only work with automated builds. Don't allow for signing bits that were built on a dev machine.
Finally, I think it would help to start implementing signing executables and scripts which get checked at runtime. Windows obviously does executable signing, but it largely doesn't sign stuff like Python scripts. JS in the browser is kind of signed given that the whole site is signed via https. It's not perfect, but it would help in preventing one program from modifying another for very sensitive contexts like web servers.