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shadowtree

2,237 karma · joined August 15, 2017

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shadowtree··on Claude for Small Business
Odd omission on CRM. They have HubSpot for Campaigns, but basic management of your customers, installed base, sales alignments, opportunities ... nothing there.

SFDC announces "Headless CRM" and Anthropic is like meh.

shadowtree··on Princeton mandates proctoring for in-person exams, upending 133 year precedent
That is not what I wrote - there was no judgement, just that other cultures weigh cheating morally different.

It is all moralities. There is no absolute one.

shadowtree··on Princeton mandates proctoring for in-person exams, upending 133 year precedent
Moral code is downstream from culture and not every culture sees cheating as a moral failing.

As Princeton's demo skewed hard into a more international student body, the underlying cultural assumptions have shifted.

The Christian extension of the Ninth Commandment from not bearing false witness to a blanket ban on lying is unique. Islam has explicit exceptions through Taqiyya, Hinduism gets nuanced with dharma and adharma, Buddhism sees it as one of the ten unwholesome actions, ...

WASPs built and defined Princeton, but that is long over.

shadowtree··on FDA approves first gene therapy for treatment of genetic hearing loss
Partisan, to the core.

How about https://www.fda.gov/news-events/press-announcements/fda-elim... ? Game changer for RWE. Not Science?

Or this one: https://www.fda.gov/news-events/press-announcements/fda-acce... ? A call for more research on certain compounds. Not Science?

I know the MSNOW daily hate machine is fun, so engaging and gives life meaning. But laying off the emo crack for a while would open your mind beyond partisan viewpoints.

shadowtree··on FDA approves first gene therapy for treatment of genetic hearing loss
Here: https://www.fda.gov/news-events/fda-newsroom/press-announcem...

Good faith, bad faith ... does not matter. Decisions and changes are public record. Read for yourself.

shadowtree··on FDA approves first gene therapy for treatment of genetic hearing loss
There has been a string of massive changes under the new admin.

Latest in this area: https://www.fda.gov/news-events/press-announcements/fda-laun...

“President Trump promised to accelerate cures for American families — and we are delivering, especially for children with ultra-rare diseases who cannot afford to wait,” said Health and Human Services Secretary Robert F. Kennedy, Jr. “We are cutting unnecessary red tape, aligning regulation with modern biology, and clearing a path for breakthrough treatments to reach the patients who need them most.”

“This guidance is a critical step the FDA is taking to tailor our regulatory approach to patients with ultra-rare conditions,” said FDA Commissioner Marty Makary, MD, MPH. “It is our priority to remove barriers and exercise regulatory flexibility to encourage scientific advances and deliver more cures and meaningful treatments for patients suffering from rare diseases.”

Now, you can be caught in the fun partisan civil war on emotions or simply look at outcomes. Good work being done at the FDA, just fact.

shadowtree··on If America's so rich, how'd it get so sad?
Crime and Grime - which is what SF is currently trying to turn around, but LA is still in full denial mode about.

Seeing a Fentanyl victim on your way to work ruins your mood.

Using Waymo as a woman because Ubers are legit rape traps anchors fear in your mind (https://www.cbsnews.com/sanfrancisco/news/disturbing-details...).

Seeing trash everywhere, alongside every freeway in the Bay Area? Subliminal assurance everything is a mess.

BART?

etc etc etc.

shadowtree··on Ancient DNA reveals pervasive directional selection across West Eurasia [pdf]
Blank Slate hypothesis is now officially refuted, correct?

Different evolutionary paths between races/regions, with impact on mental health and cognitive performance.

shadowtree··on Why the US Navy won't blast the Iranians and 'open' Strait of Hormuz
Which is why taking out the political leadership is the better tactic.

You don't need to fight armies - just make it suicide to command them. Decapitation strikes work.

"What if you had a time machine and could go back to kill Hitler?" Well yeah, no need to fight all of Germany.

Would the Ukraine war still be going without Putin at the helm?

The logical conclusion of drone war is take out whoever controls the drones.

shadowtree··on Where things stand with the Department of War
Fun fact:

DOW Chemical was producing Agent Orange, but was getting a ton of public pushback - so bad it decided to stop production, forcing the Pentagon to look for an alternative supplier.

That supplier? A German privately owned pharmaco called Boehringer-Ingelheim. It's Chairman at the time? Richard von Weizsäcker, future President of Germany.

The production site was in Hamburg, is contaminated for the next thousand years. Boehringer is legally forced to operate pumps to prevent the dioxins in that site from reaching the water table. If those did, it would wipe out the full population.

Oh those righteous Germans.

Disclosure - Boehringer denies the above: https://www.boehringer-ingelheim.com/boehringer-ingelheim-di...

Judge for yourself.

NIH on Exposure, AO and BI: https://www.ncbi.nlm.nih.gov/books/NBK230789/

Deeper dive on that BI Hamburg site: https://www.ebsco.com/research-starters/consumer-health/diox...

shadowtree··on The Gay Tech Mafia
"...part of “an insular, hypermasculine culture” in which “women are seen as totally redundant and completely unnecessary.” (A woman who once worked for a gay Republican startup founder describes it like this: “You get about the same amount of misogyny, but not the sexual harassment. So that’s nice.”)"

Tried many times to explain this to women - cis straight men are not your blockers, especially fathers.

Men who legit see you as redundant are.

"Allies" has been such an DEI Orwellian term.

Same with "racism" - up is down, left is right. Discrimination between Asians? Totally fine, zero attention, can't be true.

shadowtree··on CISA’s acting head uploaded sensitive files into public version of ChatGPT
Maduro and his bodyguards would slightly disagree.
shadowtree··on De-dollarization: Is the US dollar losing its dominance? (2025)
I believe Saddam Hussein would disagree with you, if he could.

Just bonkers how basic history is getting rewritten.

"The great satan USA" has been a slogan since the 1960s. The US dropped napalm and agent orange on Vietnamese civilians en masse - Lyndon B Johnson was what, a good guy?

What on earth are people learning about today?

shadowtree··on De-dollarization: Is the US dollar losing its dominance? (2025)
But Iraq, Afghanistan, Grenada, Panama, Vietnam ... were not a problem?

Ahistorical BS, I am sorry. As if Trump is a radical departure of NORMS. Euros were chanting HO HO HO CHI MIN in 1968 in the streets of Berlin and Paris.

There is a long tradition of anti-American feelings outside the US, like with any hegemon.

The global left had to build walls to keep their people IN, crush them with tanks, from Prague to Berlin to Beijing. So there is that.

HN turning so left is weird to watch, I guess a reflection of PG's stances and moderation/group votes. Well, money does not give a fig.

shadowtree··on Ask HN: Why isn't there competition to LinkedIn yet?
It's a self-cleaning corporate rolodex.

It solved the long running problems of: a) keeping tabs on people across company moves b) a public, standardized CV

Its moat is the scale of its network. Very, very hard to replicate, massive cold start problem. It killed business cards!

Maybe some AI generated thingy can attack it, akin to Grokipedia vs Wikipedia, but man is that unproven. Zero incentive for users to switch.

shadowtree··on Rubio stages font coup: Times New Roman ousts Calibri
Good - Calibri is not open, badly supported on Linux et al.

HN should rejoice in the US gov using a font that is open and truly cross platform.

shadowtree··on Everyone in Seattle hates AI
Everyone in Detroit hates EVs.
shadowtree··on Peter Thiel's Apocalyptic Worldview Is a Dangerous Fantasy
Which in turn were named after the original Jacobins.

...and man, did Haiti turn out to be a perfect example of Third-Worldism. Ethnocide, ecological disaster, full on regression into a post-civilizational nightmare.

shadowtree··on AI Country Singer Breaking Rust Tops Billboard with 'Walk My Walk'
There is a whole avalanche of AI "artists" hitting streaming.

A really cool one is "Camelogia Music Lab" on YT (https://www.youtube.com/channel/UCukhXIInQsJrnQwwciw-zuQ), which posts full albums of "bands" that never existed in various eclectic styles like Algerian 70s funk jazz.

The future of music is WILD.

shadowtree··on ChatGPT Atlas
I like how it officially does not support extensions.

But you click on your profile icon, top right, and voila - extensions!

Can't live without adblock.

shadowtree··on How the US got left behind in the electric car race
Love the doomerism, while millions of people would love to move to the US and others are currently fighting deportations into their local paradise tooth and nail.

So what is it now? Best country or totally behind?

With that, good luck moving to China.

shadowtree··on ABC yanks Jimmy Kimmel’s show ‘indefinitely’ after threat from FCC chair
So now that Kimmel is coming back, it is clear that it was a ABC decision and the government has no say in this - will anything in this thread change?

Of course not.

The walls of our echo chamber are made out of titanium.

shadowtree··on YouTube is a mysterious monopoly
Youtube relies on human creators.

Youtube will be disrupted by AI created, better content.

Who builds AITube? AITok?

shadowtree··on Amazon has mostly sat out the AI talent war
The Nova line of models, the AWS LLMs, are horrible. So yeah, figures.
shadowtree··on Giving people money helped less than I thought it would
The vast majority of poor people are poor due to their own actions. Low impulse control.

"I opted to be fun in high school, now I get up at 4am in the morning" is fun meme that cuts at the heart of it. Instant vs. delayed gratification and its consequences.

Source: I grew up in social housing, served in the army. Plenty of poor people around.

shadowtree··on Giving people money helped less than I thought it would
So its protection money. Give money to the poor so they don't kill you.

Awesome.

shadowtree··on AI therapy bots fuel delusions and give dangerous advice, Stanford study finds
Unlike human therapists, which have no hard oversight like this study did.
shadowtree··on GLP-1s are breaking life insurance
Canada: January 2026(!)

Novo lawyers messed up, didn't renew the patent filing over a payment dispute. Hilarity is ensuing.

https://www.cnbc.com/2025/07/09/hims-hers-generic-semaglutid...

And once generics for GLP-1s are going in Canada, Section 804 of the FD&C act becomes VERY interesting: https://www.fda.gov/about-fda/reports/importation-program-un...

Reimports of generics from Canada into the US here. we. go.

shadowtree··on ICEBlock, an app for anonymously reporting ICE sightings, goes viral
Perfect for a real life DDOS.

Want empty parking at a Dodger game? Use the ICE app.

Also a great honeypot to query out all the users of this app and schedule them for a visit.

shadowtree··on Microsoft to Cut 9k Workers in Second Wave of Major Layoffs
This pairs well with:

1 - Microsoft investing 3bn USD in India-based developers: https://www.reuters.com/technology/microsoft-invest-3-bln-ex...

2 - Microsoft having 4700 H1B filings for fiscal 2025: https://www.myvisajobs.com/employer/microsoft/

Utterly predictable behavior by Satya Nadella.

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