sapsan

I recently saw this about AlphaFold: https://elanapearl.github.io/blog/2024/the-illustrated-alpha.... I don't think it's going to answer all your question but it might still help!

I have been enjoying https://oku.club/ recently in case anyone is searching for a nicely functioning alternative.

I believe the parent refers to this [1,2,3] study. Indeed, this was about targeting many (11,923) genes with Perturb-seq (CRISPR screen with single-cell RNA-sequencing readout). There are two human cell lines used in the study (K562 and RPE1). For functional annotation, authors focused on 1,973 targeted genes that had strong transcriptional phenotype after the perturbation. As there's some correlation structure, that's what they studied, annotating clusters of individual perturbations using public databases (like STRING [4]) and literature. Seems like a lot of great work has been done here though stating that we now know all the functions of all the genes might be a bit of a stretch indeed.

[1]: https://news.mit.edu/2022/crispr-based-map-ties-every-human-... [2]: https://www.cell.com/cell/fulltext/S0092-8674(22)00597-9 [3]: https://gwps.wi.mit.edu/ [4]: https://string-db.org/

Seems to be an immortalized (telomerase*-transformed) cell line from a female fetus with near-complete homozygosity (https://sites.google.com/ucsc.edu/t2tworkinggroup/chm13-cell...).

* Telomerase is a reverse transcriptase that allows to achieve replicative immortality (https://academic.oup.com/hmg/article/9/3/403/715108).

Sounds similar to the consequences of reading Don Norman's «The Design of Everyday Things»...

Maybe something like that is relevant: https://science.sciencemag.org/content/371/6525/145. There's also a bit more context here: https://www.nature.com/articles/s41587-021-00880-0.

To add to the collection of websites recreating acoustic environments, there's https://imisstheoffice.eu for office sounds.

Rectangle (https://rectangleapp.com/) is Spectacle's successor, works great, and its source is available as well (https://github.com/rxhanson/Rectangle).

I think the quote is from the keynote itself. Here's the timestamp: https://youtu.be/GEZhD3J89ZE?t=4250.

Personally I find this [0] extension useful when it comes to using SciHub.

And yes, it seems old domains are still working.

[0]: https://chrome.google.com/webstore/detail/scihubs/jamkadfgfk...

Thanks for posting this. As a side note, I really like the style of nautil.us and their idea of writing about a single topic from different perspectives. How is this journal not very popular? (Or is it?)

Sweet Ruby syntax + close to C speed are promised. One may find this interview interesting: http://rubyc.eu/posts/24.

Nice feature, never heard of that before. Thanks!

That was nice to read. Ruby is new for me, so here's a question: is there some classy guide (like LYAH for those who start learning Haskell) for Ruby newbies?