respinal

"Nobel and Novice: Author Prominence Affects Peer Review" https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4190976

Check at the bottom: "More information: Kaito Kikuchi et al, Electrochemical potential enables dormant spores to integrate environmental signals, Science (2022)"

To be fair, I took it from the author and did some modifications. I think it was very clear how he described it. https://twitter.com/kaitochondria/status/1578083629334294529...

> some participants routinely swabbed themselves for SARS-CoV-2 testing, even if they weren’t showing symptoms. Differences in infection rates between people who received the placebo and those who got the Oxford vaccine suggest the vaccine blocks transmission, says Ewer. (The Pfizer and Moderna trials tested only people who showed symptoms.)

https://www.nature.com/articles/d41586-020-03326-w

Update: They did https://news.ycombinator.com/item?id=25579391

>the UK may approve it as early as tomorrow.

https://news.ycombinator.com/item?id=25549454

> The half-dose/full-dose regimen was a mistake in a clinic administering the trial, though.

More on that here: https://news.ycombinator.com/item?id=25548342

Yes. "COVID-19 vaccination should be offered to you regardless of whether you already had COVID-19 infection." https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html

Exactly. "BREAKING—95%—new data from Oxford/AstraZeneca vaccine shows 95% efficacy & is “100% effective” in preventing severe Hospital illness, says AZ CEO. That’s on par w/ Moderna & Pfizer. No official data yet, but UK said to likely approve in days." https://twitter.com/DrEricDing/status/1343047055078551554?s=...

I wish ;) Which title from a couple of days ago tho?

Yes, I should have posted that one. I read it as well, but read it first in Spanish from the BBC https://www.bbc.com/mundo/noticias-54429012.

Probably. I read it first in Spanish from the BBC https://www.bbc.com/mundo/noticias-54429012 and also found the one that someone quoted here from the New York Times.

Yes, it is crazy how expensive it is.

Would that be the only explanation, that they simply do not know what they do?

;)

Maybe temporary due to the New York Post's article..who knows

I still cannot tweet. I just tried it now. I get the message "Something went wrong, but don’t fret — let’s give it another shot."

It is over capacity https://downdetector.com/status/twitter/. I tried to tweet and got an error message "over capacity"

Great point and I think it is some kind of adaption or evolution, if you will.

More details: https://interestingengineering.com/that-time-when-us-army-de...

You are welcome!

For #1, I totally agree, used B cells as an example, and also implantable devices/sensors could bring more challenges (foreign body response, encapsulation, a big issue for implantable sensors). I am thinking more of a new virus detector that can be used in vitro or outside that can automatically adapt to viral changes (mutations). Let's call it "molecular morphing" virus detector, if you will (https://www.researchgate.net/figure/Principles-of-the-molecu...).

For #2, sweet! Thanks for sharing! The new virus detection platform could be used to create personalized vaccines, yes.

For #2.1, oh. Software can definitively do things faster like try million iterations until they find the "perfect match" or strong bond (from my previous comments) for viral spike proteins.

For #2.2, also agree, I am more interested in the detection/screening side of things for diseases in general.

Yes, but not better per se. I would say more adaptive or controllable (which is probably very hard to do). Nature/biology has been doing that by trial and error for years, but it takes time and it is not very efficient.

I am more interested in #2 as this could significantly improve and make robust detection/sensing systems, since viruses constantly mutate changing the binding affinities of detection/sensing systems. My background is in bioanalytical chemistry, so as soon as I read about the commonality of viral spike proteins among viruses that idea crossed my mind.

Definitely, the human body is a complex system. So if you block the viral spike protein of a virus (e.g., SARS-CoV-2), that could have some adverse effects in some people? Interesting.

Thank you for your comments! Very helpful!

Thank you for your reply! I was asking more specifically, could not write it due to characters limitation, about programming B cells (or any antibody generating system) to make antibodies to target viral spike proteins (peplomers), in an interactive or dynamic way (changing as virus mutates) , until a strong bond is reached/found (e.g., YES/NO decision). I was reading that most viruses have viral spike proteins, so if someone could do that it would be great for the treatment and detection of viral infections. Also, it could save a lot of time and money.

Yes, the CAD part is the first step. Fusion 360 has a version that you can use for free for one year (https://www.autodesk.com/products/fusion-360/personal). Fusion is very user-friendly. Depending on your 3D printer, you can 3D print a picture (2D to 3D). Mine has that option (https://www.youtube.com/watch?v=Vic6PkCgYk8), so you basically can use Microsoft Word or any program to make your design. The only issue could be the dimensions, but if it is for fun then it is OK. Also, look for any picture and 3D print it.

I basically used YouTube videos, forums (https://www.3dhubs.com/knowledge-base/how-design-snap-fit-jo...), and the instructions from the 3D printer's company. I have this one in my lab: https://www.flashforge.com/product-detail/4. I started with something very simple and only one filament. Then, did something more complex with two filaments. I have some videos here: https://randyfespinal.wixsite.com/randyespinalcabrera/3d-pri... If you are familiar with Fusion 360 or any CAD software, that helps a lot. I love fusion 360.

Yes, I have talked to some people that are skeptical about it. They say that maybe it is not PCR, but LAMP.

Maybe the next generation will do.