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poorjohnmacafee

335 karma · joined June 26, 2021

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poorjohnmacafee··on Predictors of Nonseroconversion after SARS-CoV-2 Infection
IIRC this was being discussed when testing first began, that for many their innate immune systems fight off the pathogen so quickly that it doesn't require the adaptive antibody production/retention.
poorjohnmacafee··on A newfound biomolecule, consisting of RNA modified by sugars
I don't know about "astounding" and "remains opaque". From classes I actually already (mis)assumed that rna had glycans, because almost every single thing your body produces has glycans put on it, and glycoscience is a pretty established bio subfield it seems. The surprising thing to me isn't that glycans are on rna but that researchers hadn't checked, if this groups is the first to.
poorjohnmacafee··on Why San Francisco’s city government is so dysfunctional
> about the same range of politics as everybody else

We're not talking about "rich people", that's fine and well. We're talking about classes with .5B+ levels of wealth, where it's not about subscribing to politics, it's about literally having the ability to influence politics, should they wish to. Fyi every country and civilization, ever, has had powerful interest groups that seek to control politics to further secure their position and interests. This is not surprising to anyone that this exists. Maybe the main difference today is that in this era of shell companies and the anonymity that comes with mass, global societies, it's able to be less public than before, e.g. way less public than when societies actually had open aristocracies not that long ago.

poorjohnmacafee··on Why San Francisco’s city government is so dysfunctional
Why assume that the ultra wealthy should care about the lesser citizens? What about all the rampant looting in NYC? I don't think they cared then.

Maybe many of them just aren't pro American. In almost every other country the media/politics carefully try to project some national pride and sense of unity; it's actually the opposite here in the US isn't it?

poorjohnmacafee··on Why San Francisco’s city government is so dysfunctional
I think a story about an ultra wealthy ruling class that stands behind the public political class is not going to get published in mainstream outlets. I mean it will if it's about Russia or China or historical periods like "the Gilded Age", but I guess you don't see it talked about for modern day West.
poorjohnmacafee··on Noam Chomsky – Startup Culture (2015) [video]
While of course there are startups that engineer novel and industrially relevant products, I have to agree that "startup culture" is indeed largely synonymous with "apps" (web, mobile, b2b, saas, marketplace etc.) and that this is, as he calls it, "narrow entrepreneurism".

"Narrow" given there is a vast global economy in need of hard engineering innovations - agriculture, mining, construction, energy, chemicals, biotech, manufacturing, machinery, vehicles, aerospace, science/discovery, environment/planet, telecomm, computer hardware, robotics. On the other hand apps, marketplaces, SaaS, AI, blockchain, RPA, most of the world doesn't really care about it and perhaps they shouldn't...

poorjohnmacafee··on The Fierce Legal Battle at the Heart of the Fight over Reclining Airline Seats
Even in business class I had some showdown with guy behind me who's angry he doesn't have more leg room. Early morning flight, I upgraded because I needed to sleep, and the guy wakes me up mid flight by violently kicking the back of my seat. When I turn to confront him he angrily tells me to pull my seat up. I don't even talk to him, I just buzz the flight attendant and told her what happened. She speaks to him but he started doing it again. I buzzed her again. Don't know what she said but this time he stopped.
poorjohnmacafee··on How can we make air conditioners more efficient? [video]
FYI this is an advert. Not just in resemblance to an infomercial but the youtube presenter is reaching out and quoting CTO of the company as responses to youtuber questions in comments.
poorjohnmacafee··on CFC ban bought us time to fight climate change, say scientists
Except CFCs are still on the uprise [1]

[1] https://www.nature.com/articles/s41586-019-1193-4

They sit straight in the middle of the atmospheric window, unlike CO2 which overlaps with water vapor (at around 15 microns). Hence this is perhaps an even more serious problem.

poorjohnmacafee··on The protocol designed to heal the ozone layer may also have fended off warming
Except CFCs have been on the rise [1] because not all countries follow the ban. They are a more potent GHG that fall right in the middle of the atmospheric window. It's a big deal...

https://www.nature.com/articles/s41586-019-1193-4

poorjohnmacafee··on Economic costs of war
I don't disagree with you and strongly agree we're having the wrong conversations. But in the spirit of thinking... 2 questions for you...

What is impossible about direct temperature manipulation schemes? I'm referring to proposals like building reflectors to directly lower the earth's temperature. There's nothing in principle preventing this from directly cooling the planet.

Also, what do you know about the physics of CO2 absorption/re-emission? CO2 absorbs what exactly? To start it's the 15 micron band. It is infrared radiation on the longer, weaker side of IR. How much heat does 15 microns contribute to, and what types of molecules [eg ice or water, or only atmosphere?] can actually interact with 15 microns vs. being transparent to it? Since water vapor already absorbs at 15 microns, how does that modulate the effect of CO2? Does CO2 even re-emit 15 microns back to earth, or does it just cause co2 to wiggle a little bit (it definitely causes it to wiggle, but what frequency does it re-emit, if any?) Quantifying heat caused by 15 microns is not something you will find information on, even though the entire carbon based global warming arguments depend entirely on it. But there is another relevant point to be made:

15 micron is in the terahertz spectrum specifically. This spectrum is notoriously difficult, if not impossible, to build any sort of transmitter or receiver for, mainly because the air/water vapor simply absorb it in a short distance. To this effect I've heard one college physics professor who publishes his lectures on youtube argue that 15 microns is 99.9% already absorbed in the atmosphere by such effects [1] [eg adding more CO2 will make effectively no difference at all; it's all absorbed already]. We do know the main atmospheric window where energy can reflect back into space does not include the 15 microns band [e.g. CO2's absorption profile doesn't fall in the main atmospheric window]. My question for you is how much time have you spent thinking about absorption/EM spectrum based arguments that get at the actual mechanism of how carbon based global warming is supposed to work? Most people have not. I don't have all the answers, but the physics actually seems to imply it's possible if not likely we could be completely wrong in our assumptions about CO2 and global warming. I would challenge you to come up with a rebuttal to that, in the same way folks have not come up with a rebuttal to the argument you posted. So yes, we're having the wrong conversations.

As an alternate potential explanation consistent with the physics, CFCs do absorb in the atmospheric window, and even though they were banned decades ago it turns out they are on the rise again [2]

[1] https://www.youtube.com/watch?v=57pU2F-bIQs

[2] https://www.nature.com/articles/s41586-019-1193-4

poorjohnmacafee··on Economic costs of war
I've seen too much to underestimate the MIC, as Afghanistan's hard fall could easily become "the taliban can't run a nation, we must war", as endless wars resume.
poorjohnmacafee··on Economic costs of war
Especially true given water vapor is a more potent ghg increasing with each upward temperature tick, in a way that's not linearly reversible from linear co2 reduction.

Probably the only way that could potentially fix things is direct temperature manipulation schemes. There's a lot of them that have been proposed.

Worth noting that the major economies in Asia aren't doing much of anything tangible for co2 reduction. The EU has basically the world's smallest petroleum industry so it's no sacrifice for them to push climate change measures. The US will effectively be transferring huge amounts of its economic wealth to other petroleum countries who don't care. Ugly all around.

Point is entrepreneurs should focus on direct temperature manipulation at this point if we really want to solve the problem.

poorjohnmacafee··on Costa Rica signs law to attract digital nomads
Or, devil's advocate, if you believe it's a pretty low risk disease for most of the population, and that a novel mrna vaccine falls outside your risk tolerance. Or maybe you believe if you already have natural immunity from contracting covid you shouldn't need any restrictions at all. Or maybe you believe that mask mandates don't help much since the mask pores are 5k times larger than the size of this airborne (not aerosel) virus. Or maybe you understand that therapeutics exist, eg. how India is beating the virus with ivermectin which has been around forever and widely available.

Or maybe you just think governments have overstepped and are on a slippery slope, as far as goes types of coercion methods, subtle or not, over your personal health choices.

It's not black or white. There's a ton going on in this debate, and I think any healthy skeptic should continue to look at these things closely. I think there was just a Carnegie Melon study the other day saying that those with Phd's are unexpectedly vaccine hesitant vs. general pop. Just saying covid measures - vaccines - quarantines - there is a lot of room for debate right now.

poorjohnmacafee··on The emergence of heat and humidity too severe for human tolerance (2020)
> I can say that Singapore is one of the milder places to live. It never ever gets particularly hot

Singapore is almost exactly on the equator. UV readings get up to 11 each day (extreme), whereas the most I ever saw in say SF was 5.

Your experience is one experience, mine is that it's a sauna every day of the year. I've experienced extremely hot days in terms of subjective experience of WBT as explained in article. My gf, a local here, also decries the heat. I personally cannot go running before 5:30pm. I got a major sunburn on my back at 5:30pm the time I tried running shirtless at east coast park. Granted, I am pale.

poorjohnmacafee··on The emergence of heat and humidity too severe for human tolerance (2020)
That's contradictory to leading sleep scientists like Matthew Walker, Peter Attia, etc. which is clear about need for chilly environment for sleep quality, eg < 21C. Granted, sleep science isn't oriented towards the genetics of the tropics yet, but there's plenty of evidence about temperature and sleep quality for more northern genetics anyway.
poorjohnmacafee··on The emergence of heat and humidity too severe for human tolerance (2020)
Yes, I sometimes feel like I'm at death's door when jogging outdoors. Myself and some Westerners I know haven't "adapted", even after years being here. The strategy is just always have ice water in hand if outdoors for prolonged time. I sometimes get laughed at for not adjusting to the heat, but I think it's just too much for some genetic lineages from outside tropics.

Unfortunately a large percentage of folks in HDB flats don't have AC, so I do fear for many citizens in Singapore. With global warming trends it should simply be a free or heavily subsidized utility here.

poorjohnmacafee··on Climate change: IPCC report is 'code red for humanity'
The point is reversing the CO2 does not reverse all that proportionally much larger increase in water vapor... eg. we have no choice but to address water vapor as well as CO2 if we want to have any chance in fixing global warming.
poorjohnmacafee··on Climate change: IPCC report is 'code red for humanity'
Your link is not relevant to the point made.

Just to be clear water vapor capacity increases due to temperature, for example, relative humidity measures how much water vapor is in the air for a given temperature. Any sort of increase in temperature will increase water vapor.

Yes, CO2 raises the temperature, you get a massive increase in water vapor, which again, is a more potent ghg. Reversing that same amount of CO2 does not magically reverse all of that water vapor. This is the crux of the problem, why water vapor is now also a problem that needs to be addressed.

poorjohnmacafee··on Machine learning won't solve natural language understanding
Well, have you seen any industry NLP product that exercises any meaningful level of language understanding?

I haven't. The Turing test has never even been close to being passed at the annual Loebner Prize. The best such industry NLP products I know of don't even use ML at their cores.

poorjohnmacafee··on Climate change: IPCC report is 'code red for humanity'
> But there is new hope that deep cuts in emissions of greenhouse gases could stabilise rising temperatures.

How is this possible when you have water vapor in a positive feedback loop, which is a far more potent, prevalent ghg that increases with any rise in temperature.

"Water vapor reduction" has to be part of the message at this stage, not just carbon reduction.

poorjohnmacafee··on Duolingo reaches $6.5B valuation on day of IPO
Quick look at financials, they lost $25M in trailing 12 months, lost $14M in the previous year, lost $10M in the year before.

How is Duolingo supposed to become profitable?

How is a $6.5B valuation justified?

poorjohnmacafee··on Electromagnetism is a property of spacetime itself, study finds
Want to try ELI15?
poorjohnmacafee··on Ask HN: Legal action against former employer
Thanks for the recommendations. Yes, they've been officially acquired.
poorjohnmacafee··on Visualizing all the vacant office space in San Francisco
But they aren't renting offices at multiple thousands per month. They are maybe renting cheap hot desks or doing spot booking.
poorjohnmacafee··on Visualizing all the vacant office space in San Francisco
Tangentially related I have no idea how WeWork isn't gone at this point. It's like the laws of physics are broken.
poorjohnmacafee··on Google Drive bans distribution of “misleading content”
Uh "good intentions"? I think you mean "ruling class lackeys"
poorjohnmacafee··on A haunting new documentary about Anthony Bourdain
Fyi they used deepfake AI to have him say various things. Apparently it's not clear in the doc where it's a fake and where it's the doc makers guessing what he might say.

If ask me pretty disturbing the producers claim to know him and his mind so well that they're comfortable speaking for him.

poorjohnmacafee··on Unlocking efficient light-energy conversion with stable coordination nanosheets
I assume this photodetector also uses the photoelectric effect like PV cells. Does anyone know why they wouldn't just use the more established pv tech? Said only getting efficiency of 6%.

Is there something fundamentally different about a photodetector vs. a pv cell that necessitates using different photon hitting material?

poorjohnmacafee··on I am often asked if I will “return to cryptocurrency”
Well it's easy to argue that most crypto projects are get rich quick schemes by their creators. A lot of people haven't even heard of OneCoin [1], but I think it's what most of the crypto community actually looks like when you remove the whole "progressive" or "building future" branding.

[1] https://www.youtube.com/watch?v=64xcgvEJ3Ys

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