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mpreda

437 karma · joined September 22, 2016

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mpreda··on Dual action antibiotic could make bacterial resistance nearly impossible
Trimethoprim/sulfamethoxazole is a widely used such combination antibiotic.

"Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections."

https://en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole

mpreda··on Taking my diabetes treatment into my own hands
What is your weight situation?

Eat less, exercise more, and you may delay T2D. Reduce or avoid fast carbohydrates. Reduce carbohydrates.

mpreda··on Run CUDA, unmodified, on AMD GPUs
The older AMD GCN had 64-wide wavefront, but the newer AMD GPUs "RDNA" support both 64 and 32 wavefront, and this is configurable at runtime. It appears the narrower wavefronts are better suited for games in general.

Not sure what is the situation with "CDNA", which is the compute-oriented evolution of "GCN", i.e. whether CDNA is 64-wavefront only or dual like RNDA.

mpreda··on Gpu.cpp: A lightweight library for portable low-level GPU computation
vs OpenCL, ROCm, CUDA?
mpreda··on China Reaches Record Trade Surplus, Raising Alarm Abroad
The NYTimes article talks about the growing China's trade surplus that reached 100B in June.

Yet it does not discuss the exchange rate implications of the trade imbalance. How does China manage to keep the exchange rate with USD relativelly stable in face of the large trade imbalance? Taking the exchange rate situation into account, should we be worried about China's actions, or should we rather be thankful and acknowledge a symbiotic relation with China that benefits both China and the US/EU.

mpreda··on Mitochondrial signal transduction (2022)
Mitochondria are involved in aerobic energy production in the cell, using O2 (oxygen) and some energy substrate to produce ATP (adenosyne tri-phosphate), the "energy currency of the cell".

"exercise more" means "higher energy needs", and growing the amount of mitochondria would be adaptive.

"eat less sugar" means less anaerobic energy production, I guess. Thus more aerobic energy production in exchange.

mpreda··on Effect of passenger position on crash injury risk in aircraft (2015) [pdf]
Here, take my hand luggage and go! I'll stay behind..
mpreda··on Effect of passenger position on crash injury risk in aircraft (2015) [pdf]
They should simply add the (expensive) option to buy a parachute that you may take home if unused.
mpreda··on Germany gets informal EU go-ahead to support gas-fired power, sources say
It should not have been built in the first place. That's where the billions were wasted. A strategical mistake.
mpreda··on What makes gambling wrong but insurance right? (2017)
> Insurance is primarily for major events. The things at the extreme upper end of the bell curve

That's how it should be, but isn't because all insurance contracts cap the maximum insured amount. So that's absolutely NOT the "extreme upper end of the bell", not at all.

mpreda··on How many photons are received per bit transmitted from Voyager 1?
Electromagnetic radiation includes visible light, radio spectrum, X-rays, etc. Photons.
mpreda··on How many photons are received per bit transmitted from Voyager 1?
Maybe multiple receiving antennas could be used, spaced widely apart (e.g. one on Earth, one on the moon, one in orbit somewhere); each would receive some signal affected by noise, but the noise would be different for each (such as the atmosphere affecting only the on-ground antenna). Also given that we know the precise location of the transmitter, we can work-out the exact phase difference between the antennas. Some digital post-processing would combine the raw signal+noise from the multiple receivers and extract the signal.

In fact, I assume that at this distance, even a very narrow signal would spread wide enough to illuminate more than just the Earth diameter.

mpreda··on AMD Instinct MI325X in Q4 2024, 288GB of HBM3E
I think that's where short-sighted financial gain leads AMD to. Where's the money? -- datacenter. So let's focus the good stuff on datacenter exclusivelly. What about "the rest" (gamers, hobbist, students)? There's no money there, let's give theme crap RDNA that we make sure can't be used for any real work; just pretent we're catering for their needs.

I think their "consumer GPU" did so bad recently that AMD could just as well, you know, simply liquidate the "consumer GPU" division and stop pretending.

I'm in the "consumer GPU" market myself; what AMD GPU do I buy today? -- Radeon Pro VII, launched in 2020 and the best AMD consumer GPU I can find today.

It's such a divide. I could optimize my software for such powerful GPUs as the Mi300 line.. but why do that, given that probably I won't even see one such GPU in my lifetime.

mpreda··on Superconducting Computer: Imec's plan to shrink datacenters
I would like to see more research into superconducting applied to computing, vs. the "quantum computing" applied to computing. I feel that while superconductibility is actual and proven technology that just waits to be applied to a new field (computing), QC is a "dream about the future".

OTOH I think there are theoretical lower bounds on the amount of energy that needs to be ejected as heat from a non-reversible computation, such that a non-reversible SC would still need to produce some heat.

mpreda··on US Army researched the health effects of radioactivity in St Louis 1945-1970 (2011)
What kind of window scratches? on the inside or the outside of the window? visible to the eye?
mpreda··on The world has probably passed peak pollution
Well, yes.

And, what are the ethical questions we should address first?

mpreda··on Nearsightedness is at epidemic levels – and the problem begins in childhood
> Corrective lenses definitely slow the degradation

And how do we know that? I mean, that an eye doctor would rather prescribe glasses than not, it's not surprising. The fact that they'd back up their choice by some "scientific" explanation, is only natural.

Let me offer the opposing view in the form of an example: I have been diagnosed with mild miopia (-0.5), and prescribed glasses. I did wear the glasses for a few months but at some point I lost them, and didn't go back for a replacement. Now about 20 years later, I have never again wear glasses or any other correction and I don't need them (I can read the small leters on the vision tests. I would not say that my vision is 100%, but I never need glasses to see the things in the distance). If anything, my vision improved without wearing correction!

mpreda··on Intel Gaudi 3 AI Accelerator
How much does one such card cost?
mpreda··on Ketogenic Diet Intervention on Metabolic and Psychiatric Health
Interesting. The effects of a very-low-carb diet, one such that triggers preponderently-ketone metabolism, are very-rapid-onset (24-48h) and massive. They can also be obiectively measured, by measuring the amount of ketones in urine and in blood. So I really don't see how that is compatible with the ketones being a side effect of gut species in your theory.
mpreda··on Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
> Humans are bad at lipogenesis: we can only convert tiny fraction of the carbs into fat.

Because historically food is scarce or difficult to obtain, in general organisms develop mechanisms to make good use of it: when excess food ("energy") is available, it is stored rather than wasted.

This is also true in particular for mammals, and for humans. It's quite obvious that humans are very effective at storing excess energy.

It is said that sumo fighters maintain their body mass (muscle + lots of fat) by eating rice (i.e. carbohydrates) and protein.

Lipogenesis (fat generation from carbohydrates) takes place mostly in the liver. "Excess acetyl CoA generated from excess glucose or carbohydrate ingestion can be used for fatty acid synthesis or lipogenesis."

https://courses.lumenlearning.com/suny-ap2/chapter/lipid-met...

The conclusion being: "Humans are great at lipogenesis. That's how we store excess energy."

mpreda··on In Economics Do We Know What We're Doing? Nobel Prize winner grows disenchanted
The economic models are concerned with accurately modelling the impact of normal/expected events/variations. The event you propose is not one worth modelling (being impossible).
mpreda··on Ollama now supports AMD graphics cards
ROCm includes OpenCL. And it's a very performant OpenCL implementation.
mpreda··on Blood doping and its detection
"Live high, train low"

You do need good oxygen supply during training in order to fully utilize (and grow) the muscles.

Low oxygen (such as found at high altitude) is good for the non-training periods (e.g. during sleep), where it induces a hypoxia-adaptation reaction that consists among others in increased erythropoietin (EPO), resulting in increased hemoglobin, etc.

mpreda··on Heat exchanger masks for cold weather cycling (2019)
I use an integrated device of design 1, it's called a "nose". Higher air resistance than the "mouth", but provides the heat and humidity exchange.
mpreda··on Wheel of a Delta Boeing 757 flew off while it was preparing to take off at ATL
And all airliners ocasionally have two complete-loss crashes a few months apart?

(346 people died in two similar crashes: Lion Air Flight 610 on October 29, 2018 and Ethiopian Airlines Flight 302 on March 10, 2019)

https://en.wikipedia.org/wiki/Boeing_737_MAX_groundings

mpreda··on Battery-free self-powered sensor harvests magnetic energy
Passive spying device that required no power:

https://en.wikipedia.org/wiki/The_Thing_(listening_device)

mpreda··on A man who used music to try to lure aliens to earth (2020)
It seems to me you're projecting our own human nature over all possible intelligent life.

But with a bit of imagination the potential space of intelligent life is much larger than just "displaying human-like agressive traits".

mpreda··on DARPA's air-steered X-65 jet
Could even be "fuel trimming" between front and back wings; with the drawback that the action would be limited during both full and empty fuel states.
mpreda··on New interpretations of the Cerne Abbas Giant
Clearly it's a warning to any extraterrestrials that may consider invading our planet. "I have a big stick"
mpreda··on DARPA's air-steered X-65 jet
Maybe the horizontal stabilizer trim can be replaced by a mobile weight inside the plane (moving along the front-to-back axis), that allows "trimming" the position of the center of mass.
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