misinformation

What is your basis for that BI would result in hyperinflation? If that's what you mean.

The question I responded to was along the lines of "Can calorie count reliably predict the effect on a person's weight?". Now my conclusion is that your answer that "The short answer is "no"" is wrong.

I don't see what fat cells have anything to do with this either.

As for your rebuttal of my points, it does not seem sequent. I made the point that two individuals eating the same food will gain weight differently. You then made the very same point by linking to another paper which by the way does not support what either of us said - as it measured individuals individual glycemic responses to different foods, which is not correlated with the body's calorie intake on the food.

Here's the full paper in case you did not read it (and for others to read if they'd like): http://www.sciencedirect.com.sci-hub.cc/science/article/pii/...

As for the paper, the graphics used represent outliers. Plus they in one example compared cookies and bananas. Both which have different metabolic pathways. Fructose is handled in the liver and glucose is not. When they compared bread and glucose the difference was not quite as drastic even when comparing outliers. Therefore it seems more like it has to do with varying ability in people's bodies efficiency to metabolise fructose and glucose.

I won't link to any studies but regarding [2] (gut microbiome] does affect it ever so slightly. I'm just stating things from memory now, but I remember reading that our gut bacteria now is different from 50 years ago in such a way that a person eating (for example) 2000 calories then, would now have to eat 2200. Made up numbers, but the effect was between 5-20%.

As for your last question (food composition and satiety), tangentially related, in the literature regarding this it seems as if keto has a lot of support for weight loss. Not because of the way it affects your metabolism or gut bacteria, but because it does satiate people more adequately than other diets it was tested against (regular western, Scandinavian and paleo).

To directly answer your question: if you want to use a heuristic for losing weight, it should not be to count just carbohydrates or just fats or both together -- but your total calorie intake.

The body is homoeostatic and will try to repel any change in body composition and weight. While it is also correct that different people have different metabolism and gut flora that affects our calorie conversion from different foods, the answer is yes. If you count your calories reliably, you can reliably lose weight by adjusting your calorie intake to match your body. If you throw out your body's own function of regulating its weight by measuring your food, you can accurately predict what you'll weigh in, for example, five months. It does not take years.

Noteworthy however is that with change to body composition, your TDEE (known as the amount of calories your body needs to maintain its current weight) changes. However it can easily be accounted for when losing (or gaining as may be the desired outcome for some people) in a controlled way.

Regarding the different metabolism thing: https://examine.com/faq/does-metabolism-vary-between-two-peo... (To asnwer the link's question: Yes. 600 at most calories if you compare two outliers.

Bit different answer: Yes it is possible. While it is true that two individuals eating the same food will gain weight differently, if you count your calories and measure everything you'll eventually learn (In the body building community we usually say two weeks) how many calories you need to keep your weight. With that information, you can adjust your calorie intake to lose weight. Say your maintenance is 2500 calories, then by eating 2000 instead, you'll lose 1 pound a week.

Keywords if you want to look it up more: TDEE, 1 pound = 3500 calories, calorie in calorie out