The question I responded to was along the lines of "Can calorie count reliably predict the effect on a person's weight?". Now my conclusion is that your answer that "The short answer is "no"" is wrong.

I don't see what fat cells have anything to do with this either.

As for your rebuttal of my points, it does not seem sequent. I made the point that two individuals eating the same food will gain weight differently. You then made the very same point by linking to another paper which by the way does not support what either of us said - as it measured individuals individual glycemic responses to different foods, which is not correlated with the body's calorie intake on the food.

Here's the full paper in case you did not read it (and for others to read if they'd like): http://www.sciencedirect.com.sci-hub.cc/science/article/pii/...

As for the paper, the graphics used represent outliers. Plus they in one example compared cookies and bananas. Both which have different metabolic pathways. Fructose is handled in the liver and glucose is not. When they compared bread and glucose the difference was not quite as drastic even when comparing outliers. Therefore it seems more like it has to do with varying ability in people's bodies efficiency to metabolise fructose and glucose.