metiscus

It definitely does. Anytime you reboot under graphene you see what looks like an error message with a web address to visit for several seconds from the phone, before the OS loads.

The old struggle between the Dreadnought and the Battlecruiser rears its ugly head again. It's amazing how such different things can run into the same human idioms.

I agree but I felt like giving a slightly different explanation. It is not guaranteed that you are exposed to only one variant of a pathogen as they are constantly undergoing mutation. By increasing the exposure to an antimicrobial agent, selective pressure is applied against susceptible organism variants which will increase the overall proportion of a global population that are resistant to that agent. The mitigation for this is to take enough of the antibiotic to destroy these variants as well, although this is a somewhat "leaky" containment task as you may spread the pathogen to others while undergoing treatment. This analysis so far neglects that there are other microbes in your system that you are also exposing to the antibiotic even nonpathogenic organisms that we don't normally consider when discussing antibiotic resistance. However, due to horizontal gene transfer, even nonpathogenic organisms can potentially share any developed resistances with pathogenic organisms at a later time. The only real way to protect antimicrobial agents from resistance growth is to use them extremely sparingly. Multi-drug resistant organisms have gotten bad enough that they have brought back the use of Colistin, a very old and fairly toxic drug that had fallen out of use for decades to use in cases where no other drugs work. If the world continues using these drugs at the current rate, we may see things like this become far more common.

Fundamentally we are in a war, pitting our multicellular intellect and biotechnology against our single celled brethren. It isn't as lopsided of a battle as it should be. What bacteria etc lack in individual strength, they more than make up for in multitude. I am fairly confident that in the long run we will out-innovate them but the needed systemic incentives are not currently in place to sustain our technological advantage at the present rate of resistance development.

My concern is that while doxycycline may be considered by some as a "commodity" the general class of tetracyclines is not. If you reference the linked antibiotic sensitivity chart, you'll notice that tigecycline is very broadly useful and in some cases one of two drugs that work [1]. Increasing the number of people who are taking doxycycline will expose additional pathogens to tetracyclines and cross resistance is definitely a thing. We are already seeing tigecycline resistant pathogens from agricultural use of doxycycline [2]. I'm sure that the people making these decisions are better informed about such things than I am but I do believe that we are vastly overusing anti-microbial agents in ways that future generations will come to regret.

1.https://therapeuticseducation.org/sites/therapeuticseducatio...

2.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557919/

Wickard v. Filburn[1] effectively took nearly all of the constitutional scope limits off of the federal government. All the government needs to justify interference in the most mundane of human interactions is to find a broader economic nexus in the activity.

Summarized "The Court reasoned that Congress could regulate activity within a single state under the Commerce Clause, even if each individual activity had a trivial effect on interstate commerce, as long as the intrastate activity viewed in the aggregate would have a substantial effect on interstate commerce. To this extent, the opinion went against prior decisions that had analyzed whether an activity was local, or whether its effects were direct or indirect."[2]

[1] https://supreme.justia.com/cases/federal/us/317/111/

[2] https://www.oyez.org/cases/1940-1955/317us111

Dwarf Fortress is an almost two decade project of interactive storytelling in the form of a video game. They've modeled the world down to an incredible level including personal relationships between people, races, and nations, skill growth, a mostly correct geologic model, the depth of this game is immense. The lives of each person alive in the simulated world are recorded and details are explorable etc. They model the languages spoken by the various races, basically an incredibly creative group of people just recursively modeled the world for something like 15 years adding depth where they wanted and the result is Dwarf Fortress.

CoquiAi seems very good from the work I've done with it.

I'm personally leaning towards the viral theory I've seen some research about. The general idea is that the brain produces these products as a defense to one of several viruses as a self defense mechanism but that those proteins may do bad things as well. Apparently population studies of people who take antiviral medications for herpes showed a significant decline in incidences of Alzheimer's. I haven't followed it closely lately so I am not sure if that is a return to baseline from an elevated risk (e.x. say that herpes increases baseline risk and treatment restores it) or if it might be generally applicable. Given that most drugs that have targeted Amyloid have failed to produce results so far, something like the Tau hypothesis or viral infection seem to me to be possibilities. Again, I haven't kept up lately so I would be happy to be "corrected" with some new things to read up on.

My youngest child is allergic to soy. The upside is that we're eating better food at home, the downside is that we basically can't eat anything but home cooked food, and then you must be careful because they shove soy into everything anymore. If it isn't allergen labeled, I just assume it has soy in it these days.

You are a good human. Thank you for this wonderful resource!

I have owned many Samsung android devices over the years and have always been able to install fdroid and other alternate app stores as well as "side load" applications from apk files. Is there a new thing where Samsung have removed this feature in recent (last two years or so) devices?

I suspect that the issue arises from the difference in specificity about the desired result. When we say "astronaut riding a horse" we may have preconceptions but any astronaut riding any horse will likely be acceptable while asking for a specific proof of a result in mathematics has only a very few and very specific solutions. Effectively it is like the concept in math where the area of even a large number of points is effectively zero while even small polygons or regions is nonzero. Specific things like proofs are point like knowledge while the picture of an astronaut riding a horse is a surface.

I'm not supporting OP claims exactly but there does seem to be an apparent benefit in treating herpes with antivirals to reduce the incidence of Alzheimer's. There have been a few studies and this article gives a good rundown of those although it is a few years old and there have been even more studies since. https://www.healthline.com/health-news/how-are-cold-sores-an...

Also the claims about common vaccines appear to be somewhat supported in literature. Here is a summary article https://www.alzforum.org/news/conference-coverage/could-comm...

The mind is humanity's most lethal weapon. With the "right" mindset the entire universe can become a weapon. Efforts to reduce violence tend to focus on the presence of concrete weapons (because this is easier to quantify and measure etc) with much less focus on violent ideation and the root causes of the various forms of interpersonal violence.

Reducing violence is a tricky thing because to a large extent it seems to me to be a symptom of broader and nearly intractable societal malaise. Not that it isn't worth removing nuclear weapons from circulation but the returns diminish quicker than most public policy folks seem to want to admit.

The US is a big place and water sources vary widely from place to place. Springs usually have the best tasting water but are relatively rare as municipal water sources. My hometown used a well as a water source and the town to our north used a river. Our water always had a bit of sulfur taste to it (as did my family's private well for agriculture) but the city next to us didn't have that taste. Our city was small and couldn't afford the infrastructure to get the sulfur content down and we didn't have river access.

The intended moral of the story is, while I am unfamiliar with the UK I suspect that water distribution is likely far more centralized there as the place is much smaller overall vs the US and more densely populated than most areas in the US. Higher population density means more money to build the facilities to have better tasting water. Plus a centralized administration would result in a more homogeneous quality across the region. Here in the US, each city typically runs its own water system with little to no state involvement other than periodic inspections for standards compliance.

You know, you're right about the ID verification - I didn't really think that through. You don't want your ID encoded with the ballot in a way that they can be associated.

The UUID thing is an attractive thought but it also would act as an incentive to sell ones vote. Secret ballots protect from coercion and vote selling, as you can't verify someone voted how you paid them to. With validation you could see people literally buying votes. Just something to think about. I totally agree it would be nice to have a post vote validation. Maybe you get a UUID but have to submit that in person with an ID check to view the results? That would seem to meet the intended goal and minimize the hazards but with a cost to convenience.

That was it! That was exactly what I did. Sfc fixed nothing (I've never seen it fix anything) but the PowerShell command worked flawlessly.

I ran into this last week and found a thread somewhere that resolved it for me. I can't find the link but it was a PowerShell command that enumerated all of the packages on the system and reregistered them. I wonder if it was related to this issue.

As an aside, I am always happy to see this type of discourse, HN is such a rare place. A discussion about a topic with lots of division and when people disagree, they are friendly and reasonable about it. Kudos to both of you.

Not a medical guy but ipilimumab and friends may help do that. They blockade ctla-4 which downregulates cd4 activity. A combination may result in enhanced results.

The Autobiography of Max Gergel is a similarly interesting book about chemistry with some anecdotes from the early space age. Not in print that I've found but the PDF is on archive.org

Another worry is that an engineer will see the link error and "fix it" instead of getting why it was done and diagnosing the misuse of the class.

For that to be true you would need chemically inert pipes, I can't really think of a material in common use that meets that specification. Opening the inquiry a bit to the less common materials:

Pure Soda Lime Glass

Synthetic Quartz

Diamond

Although these materials are poor choices for many reasons, they would be very unlikely to leach anything into the water more harmful than carbon or silicon atoms.

One of the only things both parties been agree on is spending lots of money. They differ only in rhetoric and what they want to spend that money on. The most fiscal restraint is usually shown when you've got a split executive - legislative across both parties since neither is inclined to work towards the other which simultaneously retards the growth of the budget slightly.

The problem is finding non smart TVs anymore. It used to be that WalMart would have a tv or two that were still just display devices but I haven't seen a non smart tv for sale in quite a while.

Honestly, I'm not a big one for regulation, but I think those TVs should have a large print notification somewhere that says they're spying on you - although people would probably accept the convenience tradeoff.

Have you looked into expungement? I'm not super familiar with how it works and it does vary state to state but you may be able to fix some of the issues via that route. There might be some public legal aid available to help because I have heard the process can be expensive and time-consuming.

This article misses the point completely. It was never about what they were looking for, it was that they were looking at all. The quiet part is, once they get acceptance of the snooping using the bogeyman of the day, it will eventually encompass other behavior up to and including political dissent etc.

I think the point was, if you were injected with the prion in a finger, how long would you have to sever that finger to prevent the prion from entering the rest of your body.

It's been a bit since I took french but that looks pretty good to me.